The Hektoen Institute of Medical Research Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

Hektoen 医学研究所站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709606
• 负责人: Karen Simpson
• 金额: $ 34.09万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709606
• 关键词: AIDS prevention; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Affect; Age; Area; Articulation; Award; Awareness; Black race; Caring; Catchment Area; Chicago; Cities; Clinic; Clinical; Clinical Trials; Collaborations; Communities; Community Health Networks; Community Outreach; Continuity of Patient Care; Contracts; County; Development; Diagnosis; Diagnostic; Education; Epidemic; Event; Foundations; Fumarates; Goals; Grant; HIV; HIV Infections; HIV diagnosis; HIV-infected adolescents; HIV/AIDS; Health; Health education; Health system; Healthcare; High Prevalence; Hispanic; Hospitals; Illinois; Individual; Infection; Infectious Diseases Research; Intervention; Intervention Studies; Laboratories; Leadership; Longitudinal cohort study; Medical Research; Methods; Midwestern United States; Modeling; Participant; Patients; Pediatric Hospitals; Persons; Pharmacy facility; Prevalence; Prevention; Prevention approach; Prevention strategy; Primary Prevention; Productivity; Provider; Public Health; Recording of previous events; Research; Research Project Grants; Research Support; Risk; Safety; Secondary Prevention; Services; Sexual Health; Sexual and Gender Minorities; Sexually Transmitted Diseases; Side; Site; Structure; Tenofovir; Testing; United States; Universities; Vulnerable Populations; Washington; Work; Youth; adolescent substance abuse; combat; community engagement; community organizations; cooking; detention center; emtricitabine; ethnic minority; experience; gender minority group; high risk; implementation intervention; improved; infection rate; innovation; low socioeconomic status; medically underserved; meetings; men who have sex with men; minority communities; multidisciplinary; new technology; operation; pre-exposure prophylaxis; preventive intervention; programs; racial minority; recruit; research study; safety net; sexual minority group; tertiary prevention; virtual

ABSTRACT Cook County Health Despite advances in Human Immunodeficiency Virus (HIV) diagnostics, care, and prevention strategies, infection rates continue to rise across the United States, particularly the medically underserved of low socio- economic status, sexual and gender minority groups, and/or racial/ethnic minority constituency, and/or substance abusing youth. There is an urgent need to reduce the number of new HIV infections among at-risk youth and improvements in numbers across the HIV care continuum. The Adolescent and Young Adult Research (AYAR) at Core Consortium will participate in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) as it has since 2001. The AYAR consortium will continue to work collaboratively within the ATN structure to assist in the development and implementation of interventional studies that address the ATN scientific priority areas across the HIV/AIDS prevention and treatment continuum among adolescents and young adults (ages 13-24) through primary, secondary, and tertiary prevention approaches. The consortium's HIV experienced, multidisciplinary clinical and community-based staff will be responsible for ATN subject recruitment, retention, and safety in our well-established adolescent HIV care program and consortium network, with the use of innovative methods, to reach the most underserved and highest risk communities of the Chicagoland area. They will continue to improve upon its leadership model with meaningful and sustainable community engagement efforts, targeting high HIV prevalence areas, leveraging local health departments and community partners in promoting and engaging youth in health care and research directed at ending the HIV epidemic. The consortium will maintain and establish new Community Based Organization (CBO) partnerships and conduct community outreach activities in targeted areas within Cook County's high HIV-affected areas and with a focus on sexual minority groups. AYAR will continue to support CBOs via in- person or virtual meetings and events, educational sessions, and sexually transmitted infection (STI) testing. AYAR will continue to maintain an active research Youth Advisory Board (YAB) with regular meetings via in person or virtual means. The consortium will increase sexual health education and awareness of HIV prevention strategies and assist with linkage to care for pre-exposure prophylaxis (PrEP) and HIV care. The AYAR will provide site, laboratory, pharmacy, and community capacities, to support impactful research studies identified by the ATN Executive Committee and Scientific Leadership Group, in collaboration with the Operations and Collaborations Center (OCC). Our investigative team has decades of experience with recruitment, prevention, and care of at-risk youth and large-scale longitudinal cohort studies. This study will capitalize upon productive existing partnerships to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the Chicagoland area in order to identify the most effective, expeditious, and scalable strategies to address this ongoing public health crisis.

摘要库克县健康 尽管人类免疫缺陷病毒（HIV）诊断，护理和预防策略的进步，但 在美国，感染率持续上升 经济状况，性和性别少数群体和/或种族/族裔少数民族选区和/或 滥用青年的物质。迫切需要减少处于危险中的新艾滋病毒感染的数量 青年和整个艾滋病毒护理连续体的数量得到改善。青少年和年轻人 核心财团的研究（AYAR）将参加艾滋病毒/艾滋病的青少年医学试验网络 自2001年以来的干预措施（ATN）。AYAR财团将继续在 ATN结构以协助开发和实施介入的研究，以解决ATN 艾滋病毒/艾滋病预防和治疗连续性的科学优先领域 通过初级，次要和第三级预防方法（13-24岁）的年轻人（13-24岁）。财团的 艾滋病毒经验丰富的多学科临床和社区工作人员将负责ATN主题 在我们成熟的青少年艾滋病毒护理计划和财团中招募，保留和安全 通过使用创新方法，网络达到了最不足和最高的风险社区 芝加哥地区。他们将继续以有意义的和 可持续的社区参与工作，针对高艾滋病毒患病率领域，利用当地健康 部门和社区合作伙伴，促进和吸引青年参与医疗保健和研究 结束HIV流行。该财团将维护并建立新的基于社区的组织 （CBO）在库克县高的目标地区的伙伴关系和开展社区外展活动 受艾滋病毒影响的地区，重点关注性少数群体。 Ayar将继续通过In- 人或虚拟会议和活动，教育会议以及性传播感染（STI）测试。 AYAR将继续维持一个活跃的研究青年顾问委员会（YAB），并通过IN定期开会 人或虚拟手段。该财团将增加性健康教育和对艾滋病毒的意识 预防策略并协助与预防前预防（PREP）和HIV护理的联系。这 AYAR将提供现场，实验室，药房和社区能力，以支持有影响力的研究 由ATN执行委员会和科学领导小组确定，与 运营与合作中心（OCC）。我们的调查团队拥有数十年的经验 高危青年和大规模纵向队列研究的招聘，预防和护理。这项研究会 利用有效的现有伙伴关系，以阐明正在进行的艾滋病毒流行的驱动因素 芝加哥地区最脆弱的人口是为了确定最有效，最迅速， 以及解决这一持续的公共卫生危机的可扩展策略。