The role of the thalamus in human olfactory processing

丘脑在人类嗅觉处理中的作用

基本信息

批准号：
8054772
负责人：
Christina Maria Zelano
金额：
$ 5.47万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8054772
关键词：
Affect Area Attention Behavioral Brain Brain region Categories Cluster Analysis Code Conscious Consumption Data Data Analyses Decision Making Detection Disease Epilepsy Fiber Food Functional Magnetic Resonance Imaging Goals Health Benefit Human Information Systems Judgment Knowledge Linear Models Medial Dorsal Nucleus Memory Methods Modality Multivariate Analysis Nature Neocortex Odors Olfactory Cortex Parkinson Disease Pathway interactions Pattern Perception Prefrontal Cortex Process Psychophysiology Rewards Role Running Scanning Schizophrenia Sensory Sensory Process Signal Transduction Smell Perception Stimulus Structure System Techniques Testing Thalamic structure Time auditory stimulus classical conditioning multisensory novel object recognition piriform cortex relating to nervous system response sensory cortex sensory stimulus sensory system visual stimulus

项目摘要

DESCRIPTION (provided by applicant): In general, conscious perception of sensory stimuli depends on a pathway to neocortex, and in all modalities except for olfaction, this requires going through the thalamus. Careful anatomical studies have found that in olfaction, the pathway between olfactory cortex and prefrontal cortex is mostly direct, with only a small contingent of fibers going to mediodorsal thalamus. This fundamental difference in the structural organization of the olfactory system indicates a qualitatively different role for the thalamus in olfactory processing. The goal of this proposal is to elucidate that role. In Aim 1, I will use fMRI to characterize the nature of intentional modulation of activity in the thalamus. By systematically altering attention to different odors, I will test the hypothesis that distributed codes of odor quality are attention dependent in the mediodorsal nucleus of the thalamus, while they are attention independent in primary olfactory cortex. In Aim 2, I will use fMRI to Using hierarchical cluster analysis and a general linear model approach to data analysis, I will be able to distinguish between olfactory brain regions that are involved in basic sensory processing, accumulation of information and moment of recognition during odor valence decisions and quality recognition. In Aim 3, I will use fMRI to ask whether the mediodorsal thalamus integrates information from multiple modalities during olfactory decisions. During scanning, subjects will smell odors that are either presented alone or paired with stimuli from other modalities, enabling us to test for multimodal olfactory response profiles in the mediodorsal thalamus.

描述（由申请人提供）：一般来说，感官刺激的有意识感知取决于通往新皮质的通路，并且在除嗅觉之外的所有模式中，这都需要通过丘脑。仔细的解剖学研究发现，在嗅觉中，嗅觉皮层和前额叶皮层之间的通路大多是直接的，只有一小部分纤维通往内侧丘脑。嗅觉系统结构组织的这种根本差异表明丘脑在嗅觉处理中的作用有本质上的不同。该提案的目的是阐明这一作用。在目标 1 中，我将使用功能磁共振成像来表征丘脑活动有意调节的性质。通过系统地改变对不同气味的注意力，我将检验这样的假设：气味质量的分布式代码在丘脑背核中是注意力依赖的，而在初级嗅皮层中是注意力独立的。在目标 2 中，我将使用功能磁共振成像来使用层次聚类分析和一般线性模型方法进行数据分析，我将能够区分参与基本感觉处理、信息积累和气味识别时刻的嗅觉大脑区域价决定和质量识别。在目标 3 中，我将使用功能磁共振成像来询问内侧丘脑在嗅觉决策过程中是否整合了多种模式的信息。在扫描过程中，受试者会闻到单独出现或与其他方式的刺激相结合的气味，使我们能够测试内侧丘脑的多模式嗅觉反应特征。