Tracking Flow of Attention in Visual Circuits Across the Brain

追踪大脑视觉回路中的注意力流动

• 批准号: 10665957
• 负责人: Bilal Haider
• 金额: $ 141.38万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665957
• 关键词: Affect; Area; Attention; Attentional deficit; Behavior; Behavioral; Brain; Cognition; Cognitive; Detection; Event; Feedback; Goals; Head; Knowledge; Lateral Geniculate Body; Location; Maps; Measurement; Measures; Methods; Monkeys; Motor; Mus; Nervous System; Neurologic; Neurons; Optics; Outcome; Pathway interactions; Perception; Population; Positioning Attribute; Psychometrics; Reaction Time; Resolution; Rewards; Sensory; Short-Term Memory; Signal Transduction; Speed; Stimulus; Syncope; Techniques; Testing; Time; Vision; Visual; Visual Cortex; Visual System; Visual attention; Visuospatial; Work; area striata; attentional modulation; behavioral response; cell type; effective therapy; expectation; experimental study; extrastriate visual cortex; flexibility; improved; individual response; information processing; inhibitory neuron; innovation; insight; neural; neuromechanism; optogenetics; receptive field; recruit; response; retinotopic; tool; visual processing; visual stimulus

PROJECT SUMMARY Sensory processing is a way to understand the nervous system in action. Behavioral context strongly affects sensory processing. For example, a brief visual stimulus is easier to detect if it appears in a predictable spatial location. This attention to visual space strongly enhances neural and behavioral responses to stimuli in those locations, but the detailed neural mechanisms spanning multiple brain areas remain unknown. This is largely because we lack the ability to measure specific neurons and circuits across multiple brain areas in real-time during behavior that elicits visual spatial attention. We are uniquely positioned to bridge this critical knowledge gap by leveraging tools for functionally targeted, multi-area recordings from genetically defined neuron subtypes to establish the timing and organization of attentional signal flow throughout the visual system during behavior. This innovative combination of techniques will enable us to 1) Establish neural timing of spatial attention across visual cortical areas 2) Establish organization of visual spatial attention networks 3) Establish laminar and cellular substrates for multi-area visual spatial attention networks SIGNIFICANCE. This project will meet a significant need to understand how an internal cognitive state—attention—modulates the intensity of external sensory events. Establishing a detailed blueprint for neural substrates of attention and sensory processing will provide greater understanding of cognitive flexibility, and provide insight for conditions characterized by deficits of attention and sensory perception. INNOVATION. This work provides technical innovation by pairing a visual attention task with optically targeted, multi-area Neuropixels population recordings from genetically resolved neuron subtypes and functionally resolved input, feedforward, and feedback pathways. We provide conceptual innovation by defining how an internal cognitive factor like attention coordinates and enhances information processing across multiple stages of a major sensory pathway.

项目概要 感觉处理是理解神经系统行为背景的一种方法。 例如，短暂的视觉刺激如果能强烈影响感觉处理，就更容易被察觉。 出现在可预测的空间位置，这种对视觉空间的关注强烈增强。 对这些位置的刺激的神经和行为反应，但详细的神经 跨越多个大脑区域的机制仍然未知，这很大程度上是因为我们缺乏。 实时测量多个大脑区域的特定神经元和电路的能力 在引起视觉空间注意的行为中，我们具有独特的优势来弥补这一点。 通过利用工具进行有针对性的功能、多区域记录来弥补关键知识差距 基因定义的神经亚型以确定注意力信号的时间和组织 行为过程中流经视觉系统。 这种创新的技术组合将使我们能够 1) 建立空间的神经时序 跨视觉皮层区域的注意力2）建立视觉空间注意力的组织 网络3）建立用于多区域视觉空间注意力的层状和细胞基质 网络 意义 该项目将满足了解内部如何运作的重要需求。 认知状态——注意力——调节外部感官事件的强度。 注意力和感觉处理的神经基质的详细蓝图将提供更大的帮助 了解认知灵活性，并提供对以缺陷为特征的情况的见解 注意力和感官知觉。 创新。这项工作通过将视觉注意力任务与 来自基因解析的光学靶向、多区域 Neuropixels 群体记录 神经亚型和功能解析输入、前馈和反馈通路。 通过定义注意力等内部认知因素如何提供概念创新 协调和增强主要感官多个阶段的信息处理 途径。