Center of Excellence in Eliminating Disparities

消除不平等卓越中心

• 批准号: 8059107
• 负责人: Elizabeth Ann Calhoun
• 金额: $ 140万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-31 至 2013-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059107
• 关键词: Adherence; Breast; Capital; Caring; Chicago; Clinical Practice Guideline; Data; Development; Diagnosis; Diagnostic; Effectiveness; Evaluation; Hospitals; Intervention; Mammography; Medically Underserved Area; National Comprehensive Cancer Network; Outcomes Research; Patients; Randomized Clinical Trials; Research; Research Infrastructure; Research Project Grants; Research Training; Resolution; Screening Result; Services; Time; Training; Woman; Work; base; cancer care; comparative effectiveness; compliance behavior; dissemination research; effectiveness research; follow-up; malignant breast neoplasm; primary outcome; standard of care

DESCRIPTION (provided by applicant): This competitive revision application supports the development of Comparative Effectiveness Research for Eliminating Disparities (CERED), which includes four CERED cores: Research, Training, Data Infrastructure, and Dissemination. The research project objective is to evaluate the effectiveness of a hospital-based patient navigation intervention strategy in mammography centers located in Medically Underserved areas (MUAs) on the adequacy of diagnostic and treatment services for breast cancer care among underserved women in Chicago. Our primary research outcome will be treatment adequacy and adherence to follow-up care in women with abnormal mammograms, as defined by The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines. This work will extend that of the ongoing comparative effectiveness research evaluating patient navigation in breast cancer care in a randomized clinical trial, in which the primary outcome is time to diagnostic resolution and treatment (Warnecke/Calhoun, P50CA106743-05; Project #1, PI: Calhoun; end date: 6/15/15). In conjunction with the existing patient navigation research project, the proposed research effort will examine comparative effectiveness of patient navigation intervention on two primary outcomes among women with abnormal mammograms (with and without breast cancer): 1) adequacy and quality of follow-up care; and 2) patient's adherence to follow-up care and treatment. The two primary hypotheses are: H 1) Navigated patients with abnormal screening results will be more likely to receive adequate diagnostic evaluations and treatment as compared to usual standard of care. H 2) Navigated patients diagnosed with breast cancer will be more likely to complete appropriate follow-up care and treatment as compared to usual standard of care. In carrying out the research project, training, data, and dissemination core activities aim to enhance scientific capital, data infrastructure, and dissemination of research findings to eliminate breast disparities.

描述（由申请人提供）：此竞争性修订申请支持消除差异比较有效性研究 (CERED) 的开发，其中包括四个 CERED 核心：研究、培训、数据基础设施和传播。该研究项目的目标是评估位于医疗服务不足地区 (MUA) 的乳房 X 线摄影中心的基于医院的患者导航干预策略的有效性，以确保芝加哥服务不足的女性获得乳腺癌护理的诊断和治疗服务的充分性。我们的主要研究成果将是根据国家综合癌症网络 (NCCN) 临床实践指南的定义，对乳房 X 光检查异常的女性进行充分的治疗和坚持随访护理。这项工作将扩展正在进行的比较有效性研究，在随机临床试验中评估乳腺癌护理中的患者导航，其中主要结果是诊断解决和治疗的时间（Warnecke/Calhoun，P50CA106743-05；项目#1，PI ：卡尔霍恩；结束日期：2015 年 6 月 15 日）。结合现有的患者导航研究项目，拟议的研究工作将检查患者导航干预对乳房X光检查异常（患有和不患有乳腺癌）的女性的两个主要结果的比较有效性：1）后续护理的充分性和质量； 2) 患者对后续护理和治疗的依从性。两个主要假设是： H 1) 与常规标准护理相比，筛查结果异常的导航患者更有可能接受充分的诊断评估和治疗。 H 2) 与通常的标准护理相比，被诊断患有乳腺癌的导航患者更有可能完成适当的后续护理和治疗。在开展研究项目时，培训、数据和传播核心活动旨在提高科学水平 资本、数据基础设施和研究成果的传播，以消除乳房差异。