A Scalable, Monolithic, DOI, TOF, MR compatible, PET Detector

可扩展、单片、DOI、TOF、MR 兼容的 PET 探测器

• 批准号: 8295983
• 负责人: Robert S Miyaoka
• 金额: $ 52.15万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8295983
• 关键词: American Cancer Society; Amplifiers; Animals; Architecture; Brain; Businesses; Characteristics; Clinical; Computer Simulation; Coupled; Custom; Detection; Development; Devices; Discipline of Nuclear Medicine; Disease; Electronics; Elements; Environment; Experimental Designs; Female; Goals; Health; Human; Human body; Hybrids; Image; Imaging technology; Individual; Investigation; Joints; Lead; Leadership; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Metric; Modality; Nuclear; PET/CT scan; Performance; Physics; Positioning Attribute; Positron-Emission Tomography; Protocols documentation; Recovery; Research; Research Proposals; Resolution; Signal Transduction; Silicon; Small Animal Imaging Systems; Surface; System; Technology; Testing; Thick; Time; Tube; United States; Universities; Washington; Work; base; cost; design; detector; image reconstruction; improved; instrumentation; magnetic field; male; novel; operation; photomultiplier; pre-clinical; programs; prototype; reconstruction; research and development; research study; sensor; simulation; solid state; two-dimensional; whole body imaging

DESCRIPTION (provided by applicant): This proposal focuses on the design and development of a scalable PET detector with depth-of-interaction (DOI) positioning capability. The basic module design will be suitable for high resolution, small animal PET imaging and clinical, time-of-flight (TOF), whole body PET imaging. The PET detector will be compatible with operation in a MR scanner. The design will utilize a low cost, thick, monolithic crystal scintillator readout by a two-dimensional array of silicon photomultiplier (SiPM) devices. A novel feature of our design is that the sensors will only be placed on the entrance surface of the scintillation detector. Preliminary results indicate that both the intrinsic X, Y spatial resolution and the effective DOI positioning accuracy are improved using the sensor on entrance plane (SEP) design versus traditional placement of the sensors on the far surface of the crystal. A key aspect of the design is the integration of the readout electronics with the detection system. To support TOF PET, a special hybrid application specific integrated circuit (ASIC) will be developed and the fist level of signal amplification will be kept as close as possible to the SiPM device using a custom pre-amplifier tile that can be placed on the entrance surface of the detector. Further, all electronics will be selected so that the detector can operate in a magnetic field environment to support PET/MRI. A 'universal' detector module that can be scaled between human whole-body, human brain, and preclinical PET imaging systems will be developed. Further, a prototype small animal PET system will be built and evaluated within this proposal. The prototype system will provide full proof of principle of the design concept. This will be especially valuable in assessing the benefits of having DOI information. In addition a set of whole- body detector modules will be built and evaluated in a gantry simulator for both their TOF, coincidence timing characteristics and potential image resolution benefits that will be provided by having both TOF and DOI positioning information. This joint research proposal brings together the University of Washington PET physics group with a long and fertile contribution to the field of nuclear and pre-clinical instrumentation and Philips, Nuclear Medicine Business Unit, with a very active research program in PET imaging and demonstrated leadership in Time-of- Flight technology and reconstruction. PUBLIC HEALTH RELEVANCE: According to the American Cancer Society one out of every two males and one out of every three females in the United States will develop cancer during their lifetime. Of individuals developing cancer about one half will die from the disease. Therefore the goal of this work is to develop new imaging technology that will aid in the battle against cancer. To do this, the detector technology that we are developing will advance the state of the art for both whole body PET/CT imaging and small animal, preclinical PET imaging systems. It will provide timing performance to support time-of-flight imaging for human, whole-body imaging protocols. The detector will also be MR compatible to support combined PET/MR imaging for both small animals and for humans. Finally, the detector will provide depth of interaction (DOI) information. DOI information will support both PET/MR imaging and provide a better combination of intrinsic spatial resolution and detection efficiency for small animal imaging systems.

描述（由申请人提供）：该提案着重于具有相互作用（DOI）定位能力的可扩展宠物探测器的设计和开发。基本的模块设计适用于高分辨率，小型动物宠物成像和临床，飞行时间（TOF），全身宠物成像。宠物探测器将与MR扫描仪中的操作兼容。该设计将利用二维硅光电层层（SIPM）设备的低成本，厚，整体晶体闪光灯读数。我们设计的一个新功能是，传感器只能放置在闪烁检测器的入口表面上。初步结果表明，使用传感器（SEP）设计的传感器与传统的传感器放置在晶体的远面，可以提高固有的X，Y空间分辨率和有效的DOI定位精度。设计的一个关键方面是将读出电子设备与检测系统的集成。为了支持TOF PET，将开发一种特殊的混合应用特定的集成电路（ASIC），并使用自定义的预放大器瓷砖将信号放大的拳头保持在与SIPM设备尽可能近的位置保持，该砖可以放置在检测器的入口表面上。此外，将选择所有电子设备，以便检测器可以在磁场环境中运行以支持PET/MRI。可以在人类全身，人脑和临床前PET成像系统之间缩放的“通用”检测器模块。此外，将在本提案中建立和评估原型小动物宠物系统。原型系统将提供设计概念原理的完整证明。这对于评估获得DOI信息的好处特别有价值。此外，将在龙门模拟器中构建和评估一组全身检测器模块，以构建其TOF，巧合时正时的特征和潜在的图像分辨率益处，这些益处将通过拥有TOF和DOI定位信息提供。这项联合研究建议将华盛顿大学宠物物理小组汇集了对核和临床前仪器和飞利浦，核医学业务部门的长期肥沃的贡献，以及在宠物成像方面非常活跃的研究计划，并在飞行时间技术和重建方面表现出了领导力。公共卫生相关性：根据美国癌症协会的说法，每两名男性中的一名，美国每三分之一的女性中的一名将在其一生中患癌症。在患癌症的个体中，大约一半将死于这种疾病。因此，这项工作的目的是开发新的成像技术，以帮助抗癌。为此，我们正在开发的检测器技术将推动全身PET/CT成像和小动物，临床前PET成像系统的最新技术。它将提供定时性能，以支持人类全身成像协议的飞行时间成像。该检测器也将是MR兼容，以支持小动物和人类的宠物/MR成像的合并成像。最后，检测器将提供交互深度（DOI）信息。 DOI信息将支持PET/MR成像，并为小动物成像系统提供了固有空间分辨率和检测效率的更好组合。

项目成果

Characterization of highly multiplexed monolithic PET / gamma camera detector modules.

• DOI: 10.1088/1361-6560/aab380
• 发表时间: 2018-03-29
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Pierce LA;Pedemonte S;DeWitt D;MacDonald L;Hunter WCJ;Van Leemput K;Miyaoka R
• 通讯作者: Miyaoka R

Evaluation of event position reconstruction in monolithic crystals that are optically coupled.

• DOI: 10.1088/0031-9155/61/23/8298
• 发表时间: 2016-12-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Morrocchi M;Hunter WC;Del Guerra A;Lewellen TK;Kinahan PE;MacDonald LR;Bisogni MG;Miyaoka RS
• 通讯作者: Miyaoka RS