Small Animal CT System

小动物CT系统

• 批准号: 8639105
• 负责人: Robert S Miyaoka
• 金额: $ 54.74万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639105
• 关键词: Anatomy; Animal Disease Models; Animal Model; Animals; Basic Science; Birds; Blood Vessels; Bone Resorption; Brain Mapping; Carotid Artery Plaques; Cell Proliferation; Communities; Convulsive therapy; Development; Disease; Disease Progression; Docking; Evaluation; Fred Hutchinson Cancer Research Center; Funding; Genomics; Goals; Grant; Heterogeneity; Hypoxia; Image; Injury; Institution; Lipolysis; Lithotripsy; Malignant Neoplasms; Measurement; Medical center; Modeling; N.I.H. Research Support; National Center for Research Resources; Neurology; Osteogenesis; PET/CT scan; Pediatric Hospitals; Pharmacology; Positron-Emission Tomography; Proteomics; Radiopharmaceuticals; Research; Research Personnel; Research Support; Resources; Role; Science; Specimen; System; Time; Tissues; Translational Research; Ultrasonography; United States National Institutes of Health; Universities; Washington; anticancer research; attenuation; cost; epigenomics; forest; improved; instrument; instrumentation; neoplastic cell; pre-clinical; programs; radiotracer; response; success; tool; tumor

DESCRIPTION (provided by applicant): This proposal is for a new small animal CT (Siemens Inveon) that will dock with our existing small animal PET system to form a small animal dual-mode PET/CT system to support basic and translational research at the University of Washington, the Fred Hutchinson Cancer Research Center, Children's Hospital and Regional Medical Center and affiliated institutions. This system will expand and enhance our imaging capabilities to provide small animal CT and small animal PET/CT to our NIH-supported research community. The vast scale and complexity of the problems that have been unearthed by genomic research into afflictions caused by disease and injury has become evident over the last decade. As genomic, proteomic, epigenomic, and other -omics, research continues to progress, a clear and effective role for pre-clinical imaging as a research tool has developed. Pre-clinical imaging and PET/CT in particular, provides evaluation of the heterogeneity of disease progression and response to therapy. In addition PET/CT imaging allows for repeated quantitative measurements over short and long time scales, thus improving efficiency and reducing the duration and cost of studies using animal models. The UW Small Animal PET Facility opened in 2008, initially supported by a NCRR Shared Instrumentation grant. The initial focus and success of the facility was in cancer research. However, the small animal PET imaging resource has attracted investigators in neurology, pharmacology, environmental and forest sciences, and vascular imaging. The success of this program has dictated a need to provide small animal dual-mode PET/CT (i.e. not just PET) and stand-alone small animal CT at our institution to support the research of our NIH funded investigators. This application describes the planned use of small animal PET/CT and small animal CT in the many research programs at our institutions. Our small animal imaging focus has been on cancer, neurology and vascular research, and the addition of a 'dockable' CT unit will expand and enhance our imaging capabilities to support this research. This system will support new research initiatives we are establishing with investigators doing ultrasound shock therapy for lithotripsy, ultrasound for histotripsy and the effects of bone formation and resorption in models of disuse. Additional projects that will initially be supported by this resource include mechanistic studies of hypoxia, lipolysis, tumor cell proliferation; tumor response to therapy and therapy optimization; carotid plaque characterization; avian brain mapping studies; and radiotracer development. The instrument we will acquire will be able to operate as a specimen and ex vivo microCT system and also supply additional CT capability to our small animal PET system to provide better anatomic localization and more accurate attenuation correction capabilities to improve tissue quantitation of biologically specific radiopharmaceuticals required in small animal disease models. Thus acquisition of this state of the art small animal CT system will make a significant contribution to the translational research goals of our highly motivated and distinguished group of investigators.

描述（由申请人提供）：该提案是针对新的小动物CT（西门子Inveon），该动物将与我们现有的小动物宠物系统对接，以形成一个小型动物双模式PET/CT系统，以支持华盛顿大学Fred Hutchinson Cancer Research Center，儿童医院和区域医疗中心以及覆盖的机构的基本和转化研究。该系统将扩展和增强我们的成像功能，为我们的NIH支持的研究社区提供小型动物CT和小型动物宠物/CT。在过去的十年中，基因组研究对疾病和受伤引起的痛苦的大规模规模和复杂性已被发现。随着基因组，蛋白质组学，表观基因组和其他 - 研究的发展，作为研究工具的开发，研究继续进行研究，这是临床前成像的明确有效作用。临床前成像和PET/CT尤其是评估疾病进展和对治疗反应的异质性。此外，PET/CT成像允许在短时间和长时间尺度上重复进行定量测量，从而提高效率并减少使用动物模型的研究持续时间和成本。 UW小型动物宠物设施于2008年开业，最初是由NCRR共享仪器赠款的支持。该设施的最初重点和成功是癌症研究。但是，小型动物宠物成像资源吸引了神经病学，药理学，环境和森林科学以及血管成像的研究者。该计划的成功决定了在我们机构中提供小动物双模式PET/CT（即不仅是PET）和独立的小动物CT，以支持我们NIH资助的研究人员的研究。该应用程序描述了在我们机构的许多研究计划中计划使用小型动物宠物/CT和小动物CT。我们的小动物成像重点一直放在癌症，神经病学和血管研究上，而“可扩展” CT单元的添加将扩展并增强我们的成像能力以支持这项研究。该系统将支持我们正在建立的新研究计划，研究人员进行超声冲击疗法以用于岩性疗法，超声进行组织摄氏，以及骨骼形成和吸收的影响。最初将由该资源支持的其他项目包括缺氧，脂解，肿瘤细胞增殖的机理研究；肿瘤对治疗和治疗优化的反应；颈动脉斑块表征；禽大脑图研究；和放射性示踪剂的发展。我们将获得的仪器将能够作为标本和离体微型CTS系统运行，并为我们的小型动物宠物系统提供额外的CT能力，以提供更好的解剖学定位，并提供更准确的衰减校正能力，以改善小型动物疾病模型中所需的生物学特异性放射性药物的组织定量。因此，获得这种最新动物CT系统的收购将为我们积极进取和杰出的研究人员的转化研究目标做出重大贡献。

项目成果

High resolution imaging of impacted CFRP composites with a fiber-optic laser-ultrasound scanner.

• DOI: 10.1016/j.pacs.2016.05.002
• 发表时间: 2016-06
• 期刊: PHOTOACOUSTICS
• 影响因子: 7.9
• 作者: Pelivanov, Ivan;Ambrozinski, Lukasz;Khomenko, Anton;Koricho, Ermias G.;Cloud, Gary L.;Haq, Mahmoodul;O'Donnell, Matthew
• 通讯作者: O'Donnell, Matthew