2012 CSHL Retroviruses Conference

2012年CSHL逆转录病毒会议

• 批准号: 8311402
• 负责人: DAVID J. STEWART
• 金额: $ 3.66万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311402
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adult; Africa; Animals; Antiviral Agents; Apoptosis; Area; Attention; Autoimmune Diseases; Biochemistry; Biology; Bovine leukemia; CD4 Positive T Lymphocytes; Cell fusion; Cells; Cellular Immunity; Chickens; Complex; DNA; Data; Dendritic Cells; Development; Disease; Embryo; Endogenous Retroviruses; Ensure; Environment; Enzymes; Equine Infectious Anemia; Etiology; Event; Evolution; Faculty; Family Felidae; Fostering; Future; General Population; Generations; Genetic; Genetic Transcription; Genome; Germ Lines; Germination; Goals; HIV; Helper-Inducer T-Lymphocyte; Human; Human Genome; Immune system; Individual; Infection; Integration Host Factors; International; Investigation; Laboratories; Lead; Life; Life Expectancy; Lymphocyte; Molecular Biology; Multiple Sclerosis; Mus; Opportunistic Infections; Oral; Orphan; Participant; Pathogenesis; Phase; Placentation; Play; Postdoctoral Fellow; Published Comment; Publishing; RNA; RNA-Directed DNA Polymerase; Request for Applications; Research Institute; Research Personnel; Resistance; Retroviridae; Retrovirology; Reverse Transcription; Role; Scientist; Seasons; Senior Scientist; Series; Spastic Paraparesis; Structure; T-Cell Leukemia; Therapeutic; Time; Transcription Process; Vaccines; Viral; Virus; Virus Diseases; Woman; Work; abstracting; antiretroviral therapy; base; cytotoxic; graduate student; interest; killings; lectures; leukemia; macrophage; meetings; pandemic disease; particle; posters; sarcoma; success; symposium

DESCRIPTION (provided by applicant): This proposal seeks support for the thirty-seventh in an annual series of meetings on "Retroviruses" to be held at Cold Spring Harbor Laboratory that has emerged as the premiere conference for this field. The proposed meeting will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the field of retrovirus biology. The meeting series is focused on the viruses and their interactions with host cells rather than the particular diseases they cause. The large majority of the work to be presented will be unpublished and subject to immediate comment and discussion by the audience. The 2012 meeting will be structured in a manner that parallels the biology of the viruses; beginning with the entry phase of the replication cycle, proceeding with post-entry events, including reverse transcription and integration, RNA-related events (transcription, processing, export, and packaging), particle assembly and release, pathogenesis/host factors, and concluding with antivirals and evolution. Selected speakers will include graduate students, postdoctoral fellows and junior faculty. Each session will be chaired by two leading scientists in the field selected by the organizers from among the registrants. Two eminent invited speakers will give special lectures to inspire and inform young scientists and to stimulate discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect ~450 retrovirologists in attendance. PUBLIC HEALTH RELEVANCE: HIV/AIDS is now a major pandemic in human beings throughout the world. According to current estimates, HIV is set to infect 90 million people in Africa, resulting in a minimum estimate of 18 million orphans. Many conferences around the world address a plethora of issues related to the treatment of HIV/AIDS, but few do so by addressing the underlying biology of the virus, and even fewer do this by putting the molecular biology of the virus and its interaction with its human host in the broader context of how all retroviruses, irrespective of host, function and evolve. A key to the success of the Cold Spring Harbor annual retroviruses conference is that the majority of oral presentations are given by graduate students, postdoctoral fellows and junior faculty chosen on the basis of scientific merit, ensuring that the conference showcases the latest developments which are often yet to be published. Participants come from academic centers, research institutes and industrial centers around the world to present and discuss their findings. Many of the currently important treatments for HIV/AIDS were first presented or proposed at this conference in past years. Importantly, this application requests support for junior scientists who might not otherwise be able to attend to actively participate in the meeting.

描述（由申请人提供）：该提案在年度关于在冷泉港实验室举行的“逆转录病毒”的会议上寻求对第三十七次的支持，该会议已成为该领域的首映会议。拟议的会议将在该领域，初级教职员工，博士后研究员和研究生组成领导者，讨论逆转录病毒生物学领域的新的，尖端的发展。会议系列的重点是病毒及其与宿主细胞的相互作用，而不是它们引起的特定疾病。大部分要展示的作品将未出版，并受到观众的立即评论和讨论。 2012年的会议将以与病毒生物学相似的方式进行结构。从复制周期的进入阶段开始，进行后进入事件，包括逆转录和集成，与RNA相关的事件（转录，处理，输出和包装），粒子组装和释放，发病机理/宿主因素，以及抗病毒和进化。选定的演讲者将包括研究生，博士后研究员和初级教师。每个会议将由组织者从注册人中选出的两名领域的主要科学家主持。两位杰出的演讲者将进行特殊的演讲，以激发和启发年轻科学家，并刺激从事相关但不同领域的科学家之间的讨论。还将有三个海报会议，大多数参与者可以展示他们的作品。这次会议的规模将是中等的，我们预计约有450名逆转录病毒学家出席了会议。 公共卫生相关性：艾滋病毒/艾滋病现在已成为世界各地人类的主要大流行。根据目前的估计，艾滋病毒将在非洲感染9000万人，最低估计为1800万孤儿。世界各地的许多会议都涉及与艾滋病毒/艾滋病治疗有关的许多问题，但是很少有人通过解决病毒的潜在生物学来解决这个问题，甚至通过将病毒的分子生物学及其与人类与人类与人类宿主的互动相互作用而在更广泛的背景下进行的逆转录病毒的方式进行，而不是托管病毒，那么宿主的疗效，以及宿主的更广泛的环境，构成宿主的范围，构成宿主的依赖，甚至更少。冷春港年度逆转录病毒会议成功的关键是，大多数口头介绍是由研究生，博士后研究员和初级教师根据科学功绩所选择的， 确保会议展示了通常尚待发布的最新发展。参与者来自世界各地的学术中心，研究机构和工业中心，以介绍和讨论他们的发现。过去几年的本次会议上首次提出或提出了许多目前对艾滋病毒/艾滋病的重要治疗方法。重要的是，该申请要求为初级科学家提供支持，这些科学家原本可能无法参加会议。