STUDYING HTT PROTEIN AGGREGATION IN CELLS

研究细胞中 HTT 蛋白质聚集

• 批准号: 8365756
• 负责人: ENRICO GRATTON
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-20 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365756
• 关键词: Cells; Fluorescence; Funding; Grant; Image; Laboratories; Length; National Center for Research Resources; Principal Investigator; Process; Proteins; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; polyglutamine; protein aggregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Imaging the Htt protein aggregation in different cells (COS7, PC12). Studying the different aggregation varying lengths of polyglutamine in the protein. Analyze the dynamics of the process of aggregation.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 对不同细胞（COS7、PC12）中的 Htt 蛋白聚集进行成像。研究蛋白质中聚谷氨酰胺不同长度的不同聚集。分析聚合过程的动力学。