SPECTRAL-SPATIAL HETEROGENEITY FOR BREAST TUMOR CHARACTERIZATION

乳腺肿瘤特征的光谱空间异质性

• 批准号: 8362728
• 负责人: ENRICO GRATTON
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362728
• 关键词: Benign; Biotechnology; Funding; Grant; Heterogeneity; Lasers; Malignant - descriptor; Mammary Gland Parenchyma; Mammary Neoplasms; National Center for Research Resources; Pathology; Population; Principal Investigator; Research; Research Infrastructure; Resources; Source; Spatial Distribution; Structure; Therapeutic Intervention; Tissues; United States National Institutes of Health; Work; absorption; breast lesion; cost; response; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Recently NIR spectral absorption signatures that may be specific to pathology in breast tissues have been discovered. These spectra, referred to as "Specific Tumor Components", or STC spectra, have been shown to distinguish between benign and malignant breast lesions. In this previous work, STC spectra from tumors were averaged together to provide a tumor STC. However, tumors are known to be heterogeneous in structure and function. We propose that heterogeneity in the STC spectra within a given volume of tissue may be indicative of the spatial distribution of distinct cellular populations within the tumor. Characterizing the types of spectral heterogeneity might therefore predict the response of the tumor to therapeutic interventions.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 最近发现了可能特定于乳腺组织病理学的近红外光谱吸收特征。 这些光谱被称为“特定肿瘤成分”或 STC 光谱，已被证明可以区分良性和恶性乳腺病变。 在之前的工作中，对肿瘤的 STC 光谱进行平均以提供肿瘤 STC。 然而，已知肿瘤在结构和功能上具有异质性。 我们提出，给定体积组织内 STC 光谱的异质性可能表明肿瘤内不同细胞群的空间分布。 因此，表征光谱异质性的类型可能会预测肿瘤对治疗干预的反应。