BIOPHYSICAL MECHANISMS FOR MODELS OF CYTOSKELETAL DYNAMICS

细胞骨架动力学模型的生物物理机制

• 批准号: 8362497
• 负责人: BORIS SLEPCHENKO
• 金额: $ 5.27万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362497
• 关键词: Biochemical; Cells; Cereals; Cytoskeletal Modeling; Event; Filament; Funding; Grant; Kinetics; Mechanics; Modeling; Movement; National Center for Research Resources; Principal Investigator; Probability; Research; Research Infrastructure; Resources; Source; Time; United States National Institutes of Health; cost; depolymerization; monomer; polymerization; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project focuses on prototyping various computational approaches, both detailed stochastic and coarse-grain continuous, to modeling cytoskeletal dynamics. A detailed stochastic approach entails kinetic Monte Carlo simulations of both biochemical events, such as nucleation of filaments and polymerization and depolymerization events, and mechanical effects, such as movements of monomers and filaments in the presence of mechanical forces and stochastic fluctuations. A continuous approximation will be formulated in terms of ensemble averages or, in more detail, in terms of probability distributions in space and time.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目侧重于制定各种计算方法，包括详细的随机和粗粒连续，以建模细胞骨架动力学。一种详细的随机方法需要对两个生化事件的动力学蒙特卡洛模拟，例如细丝的成核，聚合和解聚事件以及机械效应，例如在机械力和机械力和随机波动的情况下，单体和细丝的运动。连续近似将根据整体平均值或更详细的概率分布在时空和时间上的概率分布来制定。