BIOPHYSICAL MECHANISMS FOR MODELS OF CYTOSKELETAL DYNAMICS

细胞骨架动力学模型的生物物理机制

• 批准号: 8169570
• 负责人: BORIS SLEPCHENKO
• 金额: $ 8.16万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169570
• 关键词: Biochemical; Cereals; Computer Retrieval of Information on Scientific Projects Database; Cytoskeletal Modeling; Event; Filament; Funding; Grant; Institution; Kinetics; Mechanics; Movement; Probability; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; depolymerization; monomer; polymerization; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on prototyping various computational approaches, both detailed stochastic and coarse-grain continuous, to modeling cytoskeletal dynamics. A detailed stochastic approach entails kinetic Monte Carlo simulations of both biochemical events, such as nucleation of filaments and polymerization and depolymerization events, and mechanical effects, such as movements of monomers and filaments in the presence of mechanical forces and stochastic fluctuations. A continuous approximation will be formulated in terms of ensemble averages or, in more detail, in terms of probability distributions in space and time.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目侧重于制定各种计算方法，包括详细的随机和粗粒连续，以建模细胞骨架动力学。一种详细的随机方法需要对两个生化事件的动力学蒙特卡洛模拟，例如细丝的成核，聚合和解聚事件以及机械效应，例如在机械力和机械力和随机波动的情况下，单体和细丝的运动。连续近似将根据整体平均值或更详细的概率分布在时空和时间上的概率分布来制定。