NUMERICAL TOOLS FOR NEW CELL BIOLOGICAL MODELING CAPABILITIES IN VCELL

VCELL 中新细胞生物建模功能的数值工具

• 批准号: 8362495
• 负责人: BORIS SLEPCHENKO
• 金额: $ 2.11万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362495
• 关键词: Algorithms; Biological Models; Biomechanics; Cell model; Cells; Diffusion; Electrophysiology (science); Equation; Funding; Grant; Modeling; National Center for Research Resources; Principal Investigator; Reaction; Research; Research Infrastructure; Resources; Solutions; Source; System; United States National Institutes of Health; cost; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is aimed at implementing new capabilities within VCell for modeling cell phenomena. In particular, algorithms for solving linear elliptic (Poisson-type) equations will be implemented that are required for modeling effects of cell biomechanics and electrophysiology. Elliptic solvers are also required to find a steady-state solution of a reaction-diffusion system. In addition, other new capabilities, such as different types of boundary conditions, block solvers, etc., will be implemented.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目旨在在VCELL内实施建模细胞现象的新功能。特别是，将实施用于求解线性椭圆形（泊松类型）方程的算法，这些方程将是对细胞生物力学和电生理学的建模效应所必需的。还需要椭圆求解器才能找到反应扩散系统的稳态溶液。此外，还将实现其他新功能，例如不同类型的边界条件，块求解器等。