PROTEIN MOLECULAR IMAGING IN PATIENTS WITH LATE-LIFE MAJOR DEPRESSION

晚年重度抑郁症患者的蛋白质分子成像

• 批准号: 8363454
• 负责人: ANAND KUMAR
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363454
• 关键词: Alzheimer' s Disease; Amyloid; Binding; Binding Proteins; Biochemical; Brain; Clinical; Cognition; Cognition Disorders; Cognitive; Dementia; Diagnosis; Early identification; Elderly; Funding; Goals; Grant; Lead; Longitudinal Studies; Measures; Mental Depression; Modeling; Mood Disorders; Moods; National Center for Research Resources; Neurobehavioral Manifestations; Neurobiology; Neurofibrillary Tangles; Outcome; Patients; Pattern; Performance; Positron-Emission Tomography; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Risk; Risk Factors; Senile Plaques; Source; Time; United States National Institutes of Health; aggressive therapy; analog; computational anatomy; cost; executive function; geriatric depression; geriatric major depression; in vivo; mild neurocognitive impairment; molecular imaging; neuropathology; propylene; tau Proteins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary objective of this exploratory study is to examine the binding of protein molecules, both amyloid and tau, in the brain using positron emission tomography (PET) with fluorinated analog of 1, 1-dicyano-2-[6- (dimethylamino)-2-naphthalenyl] propene ([18F]FDDNP) in patients with late life major depression (MDD) and healthy controls. An additional goal is to examine the relationship of [18F]FDDNP binding, both globally and regionally, to specific measures of cognition (global cognition and measures of executive function and recall). Depression in late-life is both a risk factor and a prodrome for dementia, especially dementia of the Alzheimer Type (AD). FDDNP is a valid in vivo probe that binds to protein, both amyloid and tau (core biochemical components of neuritic plaques and neurofibrillary tangles in the brain respectively). FDDNP binding is higher in patients diagnosed with AD and mild cognitive impairment (MCI) when compared with control subjects and in vivo binding correlates well with post mortem evidence of neuropathology. Our proposal will help us cross- sectionally examine overall protein burden and its relationship to cognitive performance in patients with MDD. This preliminary project will lead to longitudinal studies that examine the relationship of FDDNP binding to long term clinical outcome and a comparison of binding patterns in MDD to patients diagnosed with probable AD. Our observations will have important implications for the neurobiology of mood and cognitive disorders in the elderly. 7. Project Narrative The study will help identify patients with late-life depression who may be 'at risk' for developing dementia of the Alzheimer Type over time. This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这项探索性研究的主要目的是使用正电子发射断层扫描（PET）与1，1-二酸-2-（二甲基氨基）的氟化类似物（pET）相结合，淀粉样蛋白和tau的蛋白质分子的结合，淀粉样蛋白和tau。 2-萘苯基]丙烯（[18F] FDDNP）患有晚期抑郁症（MDD）和健康对照的患者。另一个目标是研究全球和区域上[18F] FDDNP结合的关系与认知的特定衡量标准（全球认知和执行功能和回忆的度量）。晚期抑郁既是痴呆症的危险因素，又是阿尔茨海默氏症痴呆症（AD）的痴呆症。 FDDNP是一种有效的体内探针，与淀粉样蛋白和tau（分别在大脑中分别是神经斑块的核心生化成分和神经原纤维缠结）结合。与对照组受试者相比，被诊断为AD和轻度认知障碍（MCI）的患者的FDDNP结合较高，并且体内结合与神经病理的验尸证据很好地相关。我们的建议将有助于我们跨部门检查MDD患者的总体蛋白质负担及其与认知性能的关系。这个初步项目将导致纵向研究，研究FDDNP与长期临床结果的关系以及MDD中结合模式与被诊断为可能AD的患者的比较。我们的观察结果将对老年人情绪和认知障碍的神经生物学具有重要意义。 7.项目叙述这项研究将有助于确定患有晚期抑郁症的患者，这些患者可能会随着时间的流逝而发展阿尔茨海默氏症的痴呆症。这将有助于早期鉴定患者，这些患者可能会从旨在减轻情绪和认知症状的侵略性疗法中受益。