LATE-LIFE DEPRESSION: NEUROBIOLOGICAL AND CLINICAL SUBSTRATES

晚年抑郁症：神经生物学和临床基础

• 批准号: 8167065
• 负责人: ANAND KUMAR
• 金额: $ 0.53万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167065
• 关键词: Biochemical; Biological; Choline; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Elderly; Funding; Grant; Institution; Lead; Lecithin; Magnetic Resonance Spectroscopy; Major Depressive Disorder; Measures; Medical; Mental Depression; N-acetylaspartate; Neurobiology; Primary Health Care; Protons; Research; Research Personnel; Resources; Risk Factors; Role; Source; United States National Institutes of Health; base; behavior measurement; cerebrovascular; geriatric depression; insight; morphometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MAJOR DEPRESSION. To examine the role of neuroanatomical changes and overall medical burden including cerebrovascular risk factors, in the development of major depression presenting at primary care/geriatric settings. A principal objective of our study is to integrate the neuroanatomical information with clincal and behavioral measures in order to obtain a more holistic picture of the neurobiologic basis of late-life MDD. In addition to morphometry, we propose to expand our MR approaches to include proton MR Spectroscopy (MRS), to examine revlevant biochemical measures such as N-Acetyl-L-Aspartate, Choline, Lecithin and myo-inosital (mI). Collectively these neuroanatomical, biochemical and clinical measures, will provide broader insights into the biological aberrations that lead to depression in late-life MDD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 重度抑郁症。 为了研究神经解剖学变化和总体医疗负担（包括脑血管危险因素）的作用，在初级保健/老年医疗环境中出现的严重抑郁症的发展中。 我们研究的主要目的是将神经解剖学信息与clincal和行为措施相结合，以便获得更全面的神经生物学基础，以了解后期MDD的神经生物学基础。 除形态测定法外，我们还建议将MR方法扩展到包括质子MR光谱法（MRS），以检查Revlevant的生化测量，例如N-乙酰基 - 摩正酸，胆碱，卵磷脂和肌肌酸（MI）。 这些神经解剖学，生化和临床措施总体上将为导致晚期MDD抑郁症的生物畸变提供更广泛的见解。