THE CEREBROVASCULAR BASIS OF DEPRESSION IN NON INSULIN DEPENDENT DIABETES MEL

非胰岛素依赖型糖尿病梅尔抑郁症的脑血管基础

• 批准号: 7717966
• 负责人: ANAND KUMAR
• 金额: $ 0.89万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717966
• 关键词: Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diabetic Angiopathies; Functional disorder; Funding; Fundus photography; Grant; Institution; Lead; Lesion; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Pathway interactions; Patients; Research; Research Personnel; Resources; Retina; Retinal; Risk Factors; Role; Source; United States National Institutes of Health; base; brain volume; cerebrovascular; disturbance in affect; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: To examine the cerebrovascular basis of depression in patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM, type 2 diabetes). The precise role of microvascular disease in the pathophysiology of depression is unknown. Microvascular disease and depression coexist in patients with NIDDM, rendering it a unique clinical model in which to concurrently examine the role of structural abnormalities and microvascular disease in the pathophysiology of mood disturbances. Specific Aim 1: To examine the neuroanatomical correlates of depression in patients with NIDDM, we propose to use magnetic resonance imaging (MRI) to obtain volumetric estimates of brain volume and the volume of high intensity lesions in the parenchyma. Specific Aim 2: To estimate the volume of high intensity lesions in the brain parenchyma and microvascular disease in the retina, fundus photography will be utilized to estimate microvascular disease in the retina and retinal microangiopathy is conceptualized as a marker of microvascular disease in the brain. Specific Aim 3: To identify risk factors for depression and pathways that lead from clinical and neuroanatomical substrates to major depression, microvascular measures will be integrated with neuroanatomic indices in order to elucidate the pathways and mechanisms involved in the pathophysiology of depression in patients with NIDDM.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 具体目的： 检查非胰岛素依赖性糖尿病（NIDDM，2型糖尿病）患者抑郁症的脑血管基础。微血管疾病在抑郁症的病理生理学中的确切作用尚不清楚。 NIDDM患者的微血管疾病和抑郁症共存，它使其成为一个独特的临床模型，在该模型中同时检查结构异常和微血管疾病在情绪障碍的病理生理学中的作用。 具体目的1：检查NIDDM患者抑郁症的神经解剖学相关性，我们建议使用磁共振成像（MRI）获得脑体积的体积估计值和实质中高强度病变的体积。具体目的2：为了估计视网膜中脑实质和微血管疾病中高强度病变的体积，将利用眼底摄影来估计视网膜和视网膜微血管病的微血管疾病，被概念化为大脑中微血管疾病的标志。 具体目的3：确定抑郁症和从临床和神经解剖学底物导致重大抑郁症的途径的危险因素，将与神经解剖学指数集成，以阐明NIDDM患者患者抑郁症的病理生理学涉及的途径和机制。