CARDIOVASCULAR HEALTH STUDY (CHS)

心血管健康研究 (CHS)

• 批准号: 8363503
• 负责人: Oscar L. Lopez
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363503
• 关键词: Age; Alzheimer' s Disease; Amyloid beta-Protein; Brain; Cardiovascular system; Characteristics; Clinical; Cognition; Computer Retrieval of Information on Scientific Projects Database; Data; Dementia; Development; Evaluation; Funding; Future; Genetic; Grant; Health; Individual; Institution; Life Style; Magnetic Resonance Imaging; Modeling; National Center for Research Resources; Participant; Perfusion; Plasma; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Signs and Symptoms; Source; Survivors; Syndrome; United States National Institutes of Health; Vascular Diseases; cerebral atrophy; cohort; computational anatomy; cost; eligible participant; follow-up; informant; mild neurocognitive impairment; neuropsychological; population based

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cardiovascular Health Study-Cognition Study (CHS-CS), "Predictors of Alzheimer's disease (AD) in mild cognitive impairment (MCI)" (AG 20098) has carefully followed 532 non-demented participants over the past 3 years. These were 83% of the 924 eligible participants from the original CHS Pittsburgh cognition study initially established in 1992-94. The participants have been followed with annual neuropsychological evaluations, information from informants and detailed clinical information. By 2006, 32% of the normals (approximately 6% per year) and 63% of the MCIs (approximately 16% per year) will be demented; and 359 are alive in 2006, with a mean age of 86. This study has shown that most MCI convert to dementia, that many normals convert to dementia very rapidly, that the MRI findings are crucial for understanding risk, including vascular disease in the brain, global brain atrophy and focal brain abnormalities. The proposed 4-year renewal includes 3 years of follow up and repeat MRIs for the surviving cohort in order to evaluate the characteristics of individuals who survive free of dementia to determine the relationship of risk factors and MRI changes over an approximate 18-20 year follow up for the 924 participants, to analyze the relationship of lifestyles, genetic and MRI attributes to the risk of dementia, MCI and remaining normal. Most of the resources in this proposed follow up are dedicated to the detailed evaluation of the MRIs, to careful evaluation of the remaining survivors and for detailed final analysis. This is the only large population-based study for the foreseeable future with long term follow up, repeat MRIs and careful neuropsychological evaluation. From the data gathered in the first 3 years of this project, we have developed a central hypothesis to guide our research questions. Specifically, that the pathological state of AD exists years prior to the development of the clinical signs/symptoms of the dementia syndrome. We view MCI as the transitional state between normal cognition and frank dementia, and that in the absence of other comorbid conditions, MCI is AD. In this context, our study of the variables that indicate the presence of neuropathological change (e.g., structural and perfusion MRI, plasma beta-amyloid) and the factors that modify the risk to express the clinical syndrome takes on an added importance.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。心血管健康研究认知研究（CHS-CS），“在轻度认知障碍（MCI）中阿尔茨海默氏病（AD）的预测指标”（AG 20098）在过去三年中仔细仔细遵循了532名未痴呆的参与者。这些是最初于1992 - 94年成立的原始CHS匹兹堡认知研究的924名合格参与者中的83％。随后，参与者进行了年度神经心理学评估，来自线人的信息和详细的临床信息。到2006年，将有32％的正常元（每年6％）和63％的MCI（每年约16％）痴呆；和359在2006年还活着，平均年龄为86岁。这项研究表明，大多数MCI转化为痴呆症，许多正常的人非常迅速地转化为痴呆症，MRI发现对于理解风险至关重要，包括大脑，全球脑萎缩和局灶性脑异常的风险。提出的4年更新包括3年的随访和重复存活的队列的MRI，以评估在924年参与者的大约18 - 20年随访的风险因素和MRI变化的关系中，他们的特征，以确定风险和MRI属性的关系，遗传和MRI属性的关系，以降低了风险和Rementia的风险和Rementia，MCI，MCI，MCI，MCI和RESR RESS reste and MRI属性的关系。此提议的后续行动中的大多数资源都致力于对MRI的详细评估，以仔细评估其余的幸存者和详细的最终分析。这是可预见的未来唯一一项基于人群的大型研究，并进行了长期跟进，重复MRI和仔细的神经心理学评估。从该项目的前三年收集的数据中，我们开发了一个中心假设来指导我们的研究问题。具体而言，在发展痴呆综合征的临床体征/症状之前，AD的病理状态存在数年。我们将MCI视为正常认知和弗兰克痴呆症之间的过渡状态，并且在没有其他合并症的情况下，MCI是AD。在这种情况下，我们对表明神经病理学变化存在的变量的研究（例如结构和灌注MRI，血浆β-淀粉样蛋白）以及改变表达临床综合征的风险的因素具有额外的重要性。