UCLA ALZHEIMERS DISEASE RESEARCH CENTER

加州大学洛杉矶分校阿尔茨海默病研究中心

基本信息

批准号：
8363418
负责人：
JEFFREY L. CUMMINGS
金额：
$ 2.01万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8363418
关键词：
African American Alzheimer&apos s Disease Alzheimer&apos s disease model Amyloid Amyloid deposition Antibodies Apolipoproteins Award Basic Science Behavioral Brain Clinical DNA Library Data Databases Dementia Diagnosis Dimensions Doctor of Philosophy Education Frontotemporal Dementia Funding Genetic Genotype Goals Grant Hispanics Image Image Analysis Inflammation Infusion procedures Investigation Lewy Body Disease Medical center Modeling National Center for Research Resources Olives - dietary Patients Pilot Projects Population Principal Investigator Publications Publishing Research Research Infrastructure Research Personnel Resources Role Scientist Signal Transduction Source Techniques Tissues Toxic effect United States National Institutes of Health Vascular Dementia Vascular Diseases abstracting clinical research site computational anatomy cost follow-up image archival system medical schools neuropathology programs

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application proposes the establishment of an Alzheimer's Disease Research Center (ADRC) at UCLA. The theme of the ADRC is "understanding the mechanisms and optimizing the treatment of Alzheimer's disease". An ADRC would add a basic science dimension to established activities of the current UCLA Alzheimer's Disease Core Center (ADCC), use tissues and antibodies from the ADCC Neuropathology Core, and facilitate an invigorating interchange between clinical scientists and the growing cadre of basic scientists at UCLA. The ADCC has accomplished its original goals and established a flow of well characterized patients that are being followed longitudinally (Clinical Core); accessioned 148 brains into the ADCC brain bank (Neuropathology Core); created an imaging archive with sophisticated image analysis techniques available to investigators (Imaging Subcore of Imaging and Genetics Core); developed mechanisms for routine genotyping and established a DNA bank for genetic investigations (G enetics Subcore of Imaging and Genetics Core); and engaged more than 3600 clinicians in educational programs (Education/Information Transfer Core). The ADCC database contains information on 1261 patients and controls, and in the past year we have achieved an annualized follow-up rate of 90%. In the past 5 years, we have awarded funding for 12 Pilot Projects; these projects have contributed to 10 funded grants and 22 publications. The ADCC has three clinical sites, each serving a different ethnic population: UCLA (primarily majority culture patients), Martin Luther King Medical Center/Drew Medical School (primarily an African-American population), and Olive View Medical Center (an Hispanic population). UCLA investigators using data from the Cores have advanced understanding of frontotemporal dementias, dementia with Lewy bodies, behavioral aspects of AD, the role of vascular disease in AD and vascular dementia, and the role of imaging and genetics in the diagnosis and characterizatio n of AD. ADCC investigators published 375 articles and 338 abstracts on dementia-related topics between 1993 and 1997. Three basic science projects are being proposed: 1) apolipoprotein influences on amyloid deposition (Greg Cole, Ph.D.), 2) amyloid deposition, toxicity, and inflammation in an amyloid infusion model of AD )Sally Frautschy, Ph.D.) and intracellular amyloid signaling (Istvan Mody, Ph.D.). The activities of the Cores will be continued an expanded in the ADRC and the Project Leaders will be integrated into all aspects of the ADRC.

该子项目是利用资源的众多研究子项目之一由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持并且子项目的首席研究员可能是由其他来源提供的，包括其他 NIH 来源。子项目可能列出的总成本代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。该申请提议在加州大学洛杉矶分校建立阿尔茨海默病研究中心（ADRC）。 ADRC的主题是“了解阿尔茨海默病的机制并优化治疗”。 ADRC 将为当前加州大学洛杉矶分校阿尔茨海默病核心中心 (ADCC) 的既定活动增添基础科学维度，使用来自 ADCC 神经病理学核心的组织和抗体，并促进临床科学家与加州大学洛杉矶分校不断壮大的基础科学家队伍之间的交流。。 ADCC 已经实现了其最初的目标，并建立了一系列特征明确的患者流程，并进行纵向随访（临床核心）；将 148 个大脑加入 ADCC 脑库（神经病理学核心）；创建了一个成像档案，其中包含可供研究人员使用的复杂图像分析技术（成像和遗传学核心的成像子核心）；开发了常规基因分型机制并建立了用于遗传研究的 DNA 库（成像和遗传学核心的遗传学子核心）；并让 3600 多名临床医生参与教育计划（教育/信息传输核心）。 ADCC 数据库包含 1261 名患者和对照者的信息，在过去的一年里，我们实现了 90% 的年化随访率。过去5年，我们为12个试点项目提供了资助；这些项目已提供 10 项资助赠款和 22 种出版物。 ADCC 拥有三个临床中心，每个中心服务于不同的种族人群：加州大学洛杉矶分校（主要是多数文化患者）、马丁路德金医学中心/德鲁医学院（主要是非裔美国人）和 Olive View 医疗中心（主要是西班牙裔人群）。加州大学洛杉矶分校的研究人员利用核心数据，对额颞叶痴呆、路易体痴呆、AD 的行为方面、血管疾病在 AD 和血管性痴呆中的作用，以及影像学和遗传学在 AD 诊断和表征中的作用有了深入的了解。。 ADCC 研究人员在 1993 年至 1997 年间发表了 375 篇关于痴呆症相关主题的文章和 338 篇摘要。正在提议三个基础科学项目：1) 载脂蛋白对淀粉样蛋白沉积的影响（Greg Cole 博士），2) 淀粉样蛋白沉积、毒性、 AD 淀粉样蛋白输注模型中的炎症和炎症（Sally Frautschy 博士）以及细胞内淀粉样蛋白信号传导（伊斯特万·莫迪博士）。核心的活动将在 ADRC 中继续扩大，项目负责人将融入 ADRC 的各个方面。