UCLA ALZHEIMERS DISEASE RESEARCH CENTER

加州大学洛杉矶分校阿尔茨海默病研究中心

基本信息

批准号：
7955625
负责人：
JEFFREY L. CUMMINGS
金额：
$ 0.68万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7955625
关键词：
African American Alzheimer&apos s Disease Alzheimer&apos s disease model Amyloid Amyloid deposition Antibodies Apolipoproteins Archives Award Basic Science Behavioral Brain Clinical Computer Retrieval of Information on Scientific Projects Database DNA Library Data Databases Dementia Diagnosis Dimensions Doctor of Philosophy Education Frontotemporal Dementia Funding Genetic Genotype Goals Grant Hispanics Image Image Analysis Inflammation Infusion procedures Institution Investigation Lewy Body Disease Medical center Modeling Olives - dietary Patients Pilot Projects Population Publications Publishing Research Research Personnel Resources Role Scientist Signal Transduction Source Techniques Tissues Toxic effect United States National Institutes of Health Vascular Dementia Vascular Diseases abstracting clinical research site computational anatomy follow-up medical schools neuropathology programs

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This application proposes the establishment of an Alzheimer's Disease Research Center (ADRC) at UCLA. The theme of the ADRC is "understanding the mechanisms and optimizing the treatment of Alzheimer's disease". An ADRC would add a basic science dimension to established activities of the current UCLA Alzheimer's Disease Core Center (ADCC), use tissues and antibodies from the ADCC Neuropathology Core, and facilitate an invigorating interchange between clinical scientists and the growing cadre of basic scientists at UCLA. The ADCC has accomplished its original goals and established a flow of well characterized patients that are being followed longitudinally (Clinical Core); accessioned 148 brains into the ADCC brain bank (Neuropathology Core); created an imaging archive with sophisticated image analysis techniques available to investigators (Imaging Subcore of Imaging and Genetics Core); developed mechanisms for routine genotyping and established a DNA bank for genetic investigations (G enetics Subcore of Imaging and Genetics Core); and engaged more than 3600 clinicians in educational programs (Education/Information Transfer Core). The ADCC database contains information on 1261 patients and controls, and in the past year we have achieved an annualized follow-up rate of 90%. In the past 5 years, we have awarded funding for 12 Pilot Projects; these projects have contributed to 10 funded grants and 22 publications. The ADCC has three clinical sites, each serving a different ethnic population: UCLA (primarily majority culture patients), Martin Luther King Medical Center/Drew Medical School (primarily an African-American population), and Olive View Medical Center (an Hispanic population). UCLA investigators using data from the Cores have advanced understanding of frontotemporal dementias, dementia with Lewy bodies, behavioral aspects of AD, the role of vascular disease in AD and vascular dementia, and the role of imaging and genetics in the diagnosis and characterizatio n of AD. ADCC investigators published 375 articles and 338 abstracts on dementia-related topics between 1993 and 1997. Three basic science projects are being proposed: 1) apolipoprotein influences on amyloid deposition (Greg Cole, Ph.D.), 2) amyloid deposition, toxicity, and inflammation in an amyloid infusion model of AD )Sally Frautschy, Ph.D.) and intracellular amyloid signaling (Istvan Mody, Ph.D.). The activities of the Cores will be continued an expanded in the ADRC and the Project Leaders will be integrated into all aspects of the ADRC.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。该应用建议在UCLA建立阿尔茨海默氏病研究中心（ADRC）。 ADRC的主题是“了解机制并优化对阿尔茨海默氏病的治疗”。 ADRC将在当前的UCLA阿尔茨海默氏病核心中心（ADCC），使用ADCC神经病理学核心的组织和抗体中增加基础科学维度，并促进临床科学家与UCLA基础科学家不断增长的临床科学家之间的互换。 ADCC实现了其最初的目标，并建立了纵向遵循的良好特征患者（临床核心）；加入148个大脑进入ADCC脑库（神经病理学核心）；创建了一个具有复杂图像分析技术的成像档案（成像和遗传学核心的成像子核）；开发了常规基因分型的机制，并建立了遗传研究的DNA库（成像和遗传学核心的G Enetics子核）；并参与了3600多名临床医生参与教育计划（教育/信息转移核心）。 ADCC数据库包含有关1261名患者和对照组的信息，在过去的一年中，我们的年化随访率为90％。在过去的5年中，我们为12个试点项目授予了资金；这些项目为10个资助的赠款和22个出版物做出了贡献。 ADCC有三个临床地点，每个临床部门都为不同的种族服务：加州大学洛杉矶分校（主要是多数文化患者），马丁·路德·金医学中心/德鲁医学院（主要是非裔美国人人口）和Olive View医疗中心（西班牙裔人口）。 UCLA使用来自核心的数据的UCLA研究人员对额颞痴呆，痴呆症，Lewy身体的痴呆，AD的行为方面，血管疾病在AD和血管痴呆中的作用以及成像和遗传学在AD诊断和特征n中的作用。 ADCC的研究人员在1993年至1997年之间发表了375篇文章和338篇有关与痴呆有关的主题的摘要。提出了三个基础科学项目：1）载脂蛋白对淀粉样蛋白沉积的影响（Greg Cole，Ph.D.细胞内淀粉样信号传导（Istvan Mody，Ph.D。）。核心的活动将在ADRC中进行扩展，项目负责人将集成到ADRC的各个方面。