Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

跨学科神经艾滋病成瘾研究培训（TRAIN）

• 批准号: 8280353
• 负责人: Steven Paul Woods
• 金额: $ 23.03万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8280353
• 关键词: AIDS neuropathy; Research; Training; addiction

DESCRIPTION (provided by applicant): Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN) Interdisciplinary clinical research on the combined effects of substance abuse and HIV infection on brain structure and function is of considerable relevance to public health initiatives. However, there are presently very few laboratories conducting such research and no current training programs dedicated to preparing the next generation of investigators in clinical research at the intersection of addictions and neuroAIDS. Accordingly, we propose to establish a new Ruth L. Kirschstein National Research Service Award Institutional Training Grant (NRSA T32) entitled, "Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)." The aim of TRAIN is to prepare a steady state of four pre-doctoral students and two post-doctoral fellows in clinical neuropsychology for multidisciplinary academic careers focused on the central nervous system (CNS) effects of substance abuse and HIV infection. We will recruit a highly qualified and culturally diverse cohort of trainees that demonstrate promise toward achieving productive academic careers. The TRAIN program will emphasize research training in three primary, interrelated CNS outcomes, which were selected because of their salience and public health relevance as clinical features of HIV-infected substance abusers: (1) neurocognitive impairment (e.g., decision-making, memory); (2) everyday functioning (e.g., medication adherence, vocational outcomes); and (3) structural and functional neuroimaging (e.g., diffusion tensor imaging). Students and fellows will be actively engaged in individualized, flexible career development plans that will include applied research training, didactics (e.g., formal class work and structured seminars), and targeted clinical experiences. An accomplished faculty with strong training interests and a long history of collaborative research will be available to mentor the trainees. The TRAIN faculty consists of 20 mentors across multiple academic disciplines that possess considerable expertise in neural injury, neuroimaging, neuropsychology, and everyday functioning in substance abuse and HIV infection. TRAIN will be led by Dr. Steven Paul Woods and Co-Directors, Drs. Igor Grant and Robert K. Heaton, who will oversee all of the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. The TRAIN program will be housed within the Department of Psychiatry at the University of California, San Diego, where it will benefit from a resource rich academic environment that includes a strong substance abuse and neuroAIDS research infrastructure, most notably the NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC). In summary, TRAIN will bring together a bright and diverse cohort of pre- and post-doctoral trainees, an accomplished multidisciplinary team of mentors, an effective administrative structure, and broad array of academic resources to prepare the Nation's next generation of academics who will advance the science and practice of substance abuse and neuroAIDS.

描述（由申请人提供）：跨学科神经辅助研究（火车）跨学科临床研究的研究培训对药物滥用和艾滋病毒感染对大脑结构和功能的综合影响与公共卫生计划的相关性。但是，目前，进行此类研究的实验室很少，目前没有致力于在成瘾和神经辅助事件的交集中为下一代研究人员做好准备。因此，我们建议建立一个新的露丝·柯希斯坦国家研究服务奖机构培训赠款（NRSA T32），题为“跨学科神经辅助研究成瘾研究（火车）的培训”。火车的目的是准备四名博士前学生的稳定状态和两名临床神经心理学的博后研究员，用于跨学科学术职业，重点是中枢神经系统（CNS）对药物滥用和HIV感染的影响。我们将招募一个高素质和文化上多样化的学员，这表明有望实现生产力的学术职业。火车计划将强调三个主要相互关联的中枢神经系统结果的研究培训，这些培训被选择为其显着性和公共卫生的相关性，作为艾滋病毒感染药物滥用者的临床特征：（1）神经认知障碍（例如，决策，记忆，记忆，记忆）； （2）日常功能（例如，药物依从性，职业结果）； （3）结构和功能性神经影像学（例如，扩散张量成像）。学生和研究员将积极参与个性化，灵活的职业发展计划，其中包括应用研究培训，教学培训（例如，正式的课堂工作和结构化研讨会）以及针对性的临床经验。具有强大培训兴趣和悠久合作研究历史的成就良好的教师将提供指导学员。火车教职员工由多个学科的20位导师组成，在神经损伤，神经影像学，神经心理学和日常功能方面具有巨大的专业知识。火车将由史蒂文·保罗·伍兹（Steven Paul Woods）博士和联合导演博士领导。 Igor Grant和Robert K. Heaton将监督该计划的所有培训，科学和行政方面，包括严格的内部和外部评估过程。该火车计划将安置在加利福尼亚大学圣地亚哥分校的精神病学系中，在那里它将受益于资源丰富的学术环境，其中包括强大的药物滥用和神经辅助研究基础设施，最著名的是NIDA资助的转化甲基苯丙胺艾滋病艾滋病研究中心（TMARC）。总而言之，Train将汇集一系列明亮而多样的学期学员，一支成就良好的多学科导师团队，有效的行政结构以及广泛的学术资源，以准备美国下一代的学者，他们将促进药物滥用和神经辅助的科学和实践。