Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

跨学科神经艾滋病成瘾研究培训（TRAIN）

• 批准号: 8786128
• 负责人: Steven Paul Woods
• 金额: $ 5.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8786128
• 关键词: AIDS neuropathy; Research; Training; addiction

DESCRIPTION (provided by applicant): Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN) Interdisciplinary clinical research on the combined effects of substance abuse and HIV infection on brain structure and function is of considerable relevance to public health initiatives. However, there are presently very few laboratories conducting such research and no current training programs dedicated to preparing the next generation of investigators in clinical research at the intersection of addictions and neuroAIDS. Accordingly, we propose to establish a new Ruth L. Kirschstein National Research Service Award Institutional Training Grant (NRSA T32) entitled, "Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)." The aim of TRAIN is to prepare a steady state of four pre-doctoral students and two post-doctoral fellows in clinical neuropsychology for multidisciplinary academic careers focused on the central nervous system (CNS) effects of substance abuse and HIV infection. We will recruit a highly qualified and culturally diverse cohort of trainees that demonstrate promise toward achieving productive academic careers. The TRAIN program will emphasize research training in three primary, interrelated CNS outcomes, which were selected because of their salience and public health relevance as clinical features of HIV-infected substance abusers: (1) neurocognitive impairment (e.g., decision-making, memory); (2) everyday functioning (e.g., medication adherence, vocational outcomes); and (3) structural and functional neuroimaging (e.g., diffusion tensor imaging). Students and fellows will be actively engaged in individualized, flexible career development plans that will include applied research training, didactics (e.g., formal class work and structured seminars), and targeted clinical experiences. An accomplished faculty with strong training interests and a long history of collaborative research will be available to mentor the trainees. The TRAIN faculty consists of 20 mentors across multiple academic disciplines that possess considerable expertise in neural injury, neuroimaging, neuropsychology, and everyday functioning in substance abuse and HIV infection. TRAIN will be led by Dr. Steven Paul Woods and Co-Directors, Drs. Igor Grant and Robert K. Heaton, who will oversee all of the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. The TRAIN program will be housed within the Department of Psychiatry at the University of California, San Diego, where it will benefit from a resource rich academic environment that includes a strong substance abuse and neuroAIDS research infrastructure, most notably the NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC). In summary, TRAIN will bring together a bright and diverse cohort of pre- and post-doctoral trainees, an accomplished multidisciplinary team of mentors, an effective administrative structure, and broad array of academic resources to prepare the Nation's next generation of academics who will advance the science and practice of substance abuse and neuroAIDS.

描述（由申请人提供）：跨学科神经艾滋病成瘾研究培训（TRAIN） 关于药物滥用和艾滋病毒感染对大脑结构和功能的综合影响的跨学科临床研究与公共卫生举措具有相当大的相关性。然而，目前进行此类研究的实验室很少，目前也没有专门为下一代成瘾和神经艾滋病交叉临床研究研究人员做好准备的培训计划。因此，我们建议设立一项新的露丝·L·基尔施斯坦国家研究服务奖机构培训补助金（NRSA T32），题为“跨学科神经艾滋病成瘾研究培训（TRAIN）”。 TRAIN 的目的是为临床神经心理学领域的四名博士前学生和两名博士后研究员做好稳定的准备，以从事多学科学术职业，重点关注药物滥用和艾滋病毒感染对中枢神经系统（CNS）的影响。我们将招募一批高素质、文化多元化的学员，他们有望实现富有成效的学术生涯。 TRAIN 计划将强调三个主要的、相互关联的 CNS 结果的研究培训，之所以选择这些结果是因为它们作为艾滋病毒感染者的药物滥用者的临床特征的显着性和公共卫生相关性：（1）神经认知障碍（例如决策、记忆） ; (2) 日常功能（例如药物依从性、职业成果）； (3)结构和功能神经成像（例如扩散张量成像）。学生和研究员将积极参与个性化、灵活的职业发展计划，其中包括应用研究培训、教学（例如正式课堂作业和结构化研讨会）和有针对性的临床经验。具有强烈培训兴趣和长期合作研究历史的优秀教师将可以指导学员。 TRAIN 教职人员由 20 名跨多个学科的导师组成，他们在神经损伤、神经影像学、神经心理学以及药物滥用和艾滋病毒感染的日常功能方面拥有丰富的专业知识。 TRAIN 将由 Steven Paul Woods 博士和联合主任 Drs. 领导。伊戈尔·格兰特（Igor Grant）和罗伯特·K·希顿（Robert K. Heaton）将监督该计划的所有培训、科学和行政方面，包括严格的内部和外部评估过程。 TRAIN 项目将设在圣地亚哥加利福尼亚大学精神病学系，该系将受益于资源丰富的学术环境，其中包括强大的药物滥用和神经艾滋病研究基础设施，尤其是 NIDA 资助的转化型甲基苯丙胺艾滋病研究基础设施研究中心（TMARC）。总而言之，TRAIN 将汇集一批才华横溢、多元化的博士前和博士后学员、一支卓有成效的多学科导师团队、有效的管理结构和广泛的学术资源，为国家下一代学者做好准备，推动他们的进步。药物滥用和神经艾滋病的科学和实践。