Prospective Memory in HIV-1 Infection

HIV-1 感染中的前瞻性记忆

• 批准号: 7026523
• 负责人: Steven Paul Woods
• 金额: $ 30.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-04 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026523
• 关键词: AIDS /HIV neuropathy; HIV infections; antiAIDS agent; behavioral /social science research tag; clinical research; cognition disorders; executive function; functional ability; helper T lymphocyte; human subject; leukocyte count; memory disorders; neuropathology; neuropsychological tests; patient oriented research; prefrontal lobe /cortex; therapy compliance; virus load; AIDS /HIV neuropathy; HIV infections; antiAIDS agent; behavioral /social science research tag; clinical research; cognition disorders; executive function; functional ability; helper T lymphocyte; human subject; leukocyte count; memory disorders; neuropathology; neuropsychological tests; patient oriented research; prefrontal lobe /cortex; therapy compliance; virus load

DESCRIPTION (provided by applicant): Despite considerable scientific progress over the past 15 years, notable limitations persist in the theoretical and clinical significance of memory assessment in persons with HIV-1 infection. The overarching aim of this revised multidisciplinary project is to provide a conceptually-driven approach to delineating the impact of HIV-1 infection on prospective memory (ProM). ProM is a unique aspect of episodic memory sensitive to fronto-striatal damage that encompasses the complex processes of forming, monitoring, and executing future intentions vis-a-vis ongoing distractions. Consideration of ProM can enhance prediction of- and interventions related to - instrumental activities of daily living (lADLs). It is therefore surprising that ProM has not been evaluated in HIV-1, especially given the fronto-striatal neuropathogenesis of HIV-1-associated memory deficits and their impact on lADLs. Accordingly, this revised research application is guided by the following specific aims: 1) to clarify the nature, extent, and disease correlates of ProM impairment in HIV-1 infection; 2) to delineate the cognitive mechanisms of ProM impairment in HIV-1 using both clinical and experimental measures; and 3) to assess the efficacy of ProM in predicting lADLs (e.g., medication adherence) in HIV-1. We will recruit 200 HIV+ participants and 50 demographically comparable controls to evaluate the following primary hypotheses: 1) HIV-1 infection is associated with deficient executive control of encoding and retrieval within ProM; 2) ProM impairment is associated with advanced HIV-1 disease (e.g., viral load); and 3) ProM provides incremental validity relative to traditional cognitive tests in predicting lADLs, including medication adherence. This study promises to produce important conceptual and practical innovations regarding the nature and clinical assessment of HIV-associated cognitive disorders, and may ultimately facilitate the development of ProM-based interventions to minimize the impact of cognitive disorders on persons with HIV-1 infection, caregivers, and the health care system.

描述（由申请人提供）：尽管过去15年中有很大的科学进步，但在HIV-1感染患者中记忆评估的理论和临床意义持续存在明显的局限性。这个经过修订的多学科项目的总体目的是提供一种概念驱动的方法来描述HIV-1感染对潜在记忆的影响（PROM）。 PROM是对额 - 纹状体损害敏感的情节记忆的独特方面，它涵盖了形成，监视和执行未来意图的复杂过程，以进行持续的干扰。对舞会的考虑可以增强与日常生活（LADL）工具活动相关的干预措施的预测和干预措施。因此，令人惊讶的是，尚未在HIV-1中评估PROM，尤其是考虑到HIV-1相关记忆缺陷的额叶神经病发生及其对LADL的影响。因此，这项修订的研究申请受以下具体目的指导：1）阐明HIV-1感染中舞会障碍的性质，程度和疾病相关性； 2）使用临床和实验措施来描述HIV-1中PROM损伤的认知机制； 3）评估PROM在HIV-1中预测LADL（例如药物依从性）方面的功效。我们将招募200名HIV+参与者和50个人口统计学可比的控制，以评估以下主要假设：1）HIV-1感染与PROM内的编码和检索的不足有关； 2）舞会障碍与晚期HIV-1疾病（例如病毒载量）有关； 3）PROM相对于预测LADL的传统认知测试提供了增量有效性，包括药物依从性。这项研究有望就与HIV相关的认知障碍的性质和临床评估产生重要的概念和实践创新，并最终可能促进基于Prom的干预措施的发展，以最大程度地减少认知障碍对HIV-1感染，护理人员，护理人员和医疗保健系统的影响。