Center for Quantitative Biology

定量生物学中心

• 批准号: 8327818
• 负责人: DAVID BOTSTEIN
• 金额: $ 294.31万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8327818
• 关键词: Algorithms; Area; Bioinformatics; Biological; Biological Process; Biological Sciences; Biology; Chemistry; Communication; Communities; Complex; Computer Analysis; Core Facility; Data; Data Set; Diagnostic; Discipline; Disease; Ecology; Education; Educational Curriculum; Educational process of instructing; Environment; Faculty; Genomics; Goals; Image; Imagery; Joints; Learning; Life; Malignant Neoplasms; Methods; Modeling; Molecular Biology; Organism; Paper; Pattern; Physics; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Resources; Signal Transduction; Structure; Students; System; Systems Biology; Technology; Therapeutic; Thinking; computer science; graduate student; improved; meetings; metabolomics; multidisciplinary; pathogen; programs; undergraduate education; undergraduate student

The overarching goal of the proposed Center for Quantitative Biology remains to instantiate at Princeton a research and teaching environment that fully meets the challenge and opportunity, presented by advances in computation and genomics, to practice a usefully quantitative biological science, sometimes referred to as "systems biology". The programs and infrastructure of the Center increase the bandwidth of communication among researchers from different disciplines and departments (including Molecular Biology, Ecology and Evolutionary Biology, Computer Science, Chemistry and Physics). One in four (54/217) papers published with Center support in the last four years is a joint publication between two or more Center faculty. For both undergraduate and graduate students, the Center provides a focus for multidisciplinary teaching and learning; quantitative and biological ideas are integrated from the beginning, with the result that students acquire nearly equal facility in biological and quantitative thinking. The Center's specific aims are: (1) to develop realistic and quantitative models of biological processes; (2) to collect large-scale data sets that comprehensively describe biological processes; (3) to devise new and improved methods for computational analysis and display of complex models, structures and data and to make, upon publication, all underlying data, algorithms and analytical systems publicly accessible; (4) to devise and support new curricula and courses of quantitative biology education for undergraduates, graduate students, and the larger scientific community; and (5) to reduce these ideas to practice in several collaborative and multi-disciplinary projects, each aimed at specific system-level questions in the subject areas of (i) intracellular signaling, (ii) pattern and cell signaling in multicellular organisms, (iii) host-pathogen interactions and (iv) bioinformatics and data visualization. These projects share common quantitative goals, require a common infrastructure (i.e. computation, microarray, imaging and metabolomics core facilities) and all of them benefit from the intellectual synergy and multi-disciplinary cooperation that the Center provides.

拟议的定量生物学中心的总体目标仍然是在普林斯顿实例化的研究和教学环境，该研究和教学环境完全满足了计算和基因组学进步的挑战和机会，以实践有效的定量生物科学，有时称为“系统生物学”。该中心的计划和基础设施增加了来自不同学科和部门的研究人员（包括分子生物学，生态学和进化生物学，计算机科学，化学和物理学）之间交流的带宽。在过去四年中，有四分之一（54/217）的论文是中心支持的，这是两个或多个中心教师之间的共同出版物。对于本科生和研究生，该中心为多学科教学提供了重点；定量和生物学思想从一开始就整合在一起，结果学生在生物学和定量思维中获得了几乎平等的设施。该中心的具体目的是：（1）开发生物过程的现实和定量模型； （2）收集大规模数据集，以全面描述生物学过程； （3）设计新的和改进的方法来计算分析和显示复杂模型，结构和数据，并在出版时制作所有基础数​​据，算法和分析系统，可公开访问； （4）为本科生，研究生和更大的科学界设计和支持定量生物学教育的新课程和课程； （5）将这些想法减少在几个协作和多学科项目中进行练习，每个项目都针对（i）（i）细胞内信号传导，（ii）多细胞生物体中的模式和细胞信号传导的特定系统级问题，（iii）宿主 - 托管机构相互作用以及（iiv）生物信息信息和数据可视化。这些项目具有共同的定量目标，需要共同的基础架构（即计算，微阵列，成像和代谢组学核心设施），并且所有这些都受益于中心提供的知识协同和多学科合作。