Integrating and Disseminating Functional Genomics Data

整合和传播功能基因组数据

基本信息

批准号：
7208029
负责人：
DAVID BOTSTEIN
金额：
$ 55.53万
依托单位：
PRINCETON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7208029
关键词：
Algorithms Behavior Binding Binding Sites Biological Biological Process Cell Cycle Cellular biology Classification Co-Immunoprecipitations Collaborations Collection Communities Computer software Computing Methodologies Condition Controlled Vocabulary Data Data Set Databases Deposition Development Exhibits Explosion Gene Expression Generic Drugs Genes Genome Genomics Genus Mentha Goals Hybrids Imagery Individual Intention Internet Investigation Knowledge Link Literature Methodology Methods Mining Organism Paper Pathway interactions Printing Probability Process Production Publications Publishing Quality Control Research Research Personnel Resources Role Route Running Saccharomyces Scheme Scientist Score Seeds Site Source Specificity Standards of Weights and Measures Suggestion System Systems Integration Techniques Technology Testing Update Yeasts base concept data integration design file format functional genomics gene function genome database improved interest model organisms databases novel novel strategies programs repository research study tool transcription factor web interface yeast two hybrid system

项目摘要

DESCRIPTION (provided by applicant): The explosion of genome-wide research over the last decade has made clear the need for a new paradigm for the way in which biological information is integrated and disseminated to the research community. Thus, the overall goal of this proposal is to devise and implement systems that make possible continuing integration of the information contained within genomic data sets, including, at a minimum, gene expression, 2-hybrid, synthetic lethality, and systematic deletion studies, and to make the integrated information accessible to the research community, initially through the Saccharomyces Genome Database (SGD), and later through other model organism databases as we create a generally applicable system and submit it to the Generic Model Organism Database (GMOD) project. We envision that information from the data sets will become accessible through 2 general routes: first, the data integration system will be a guide to curators in assessing what is known about the function of genes, especially those genes for which little is known; second, we will organize the integrated data, on a continuing basis, into a schema that can be queried directly. By providing multiple sources of information and the tools to integrate and query them in new and better ways, we aim to help biologists progress toward seeing individual genes or pathways of interest in a more global context. Equally important, we hope to add to our knowledge of the biological roles of individual genes from knowledge of their behavior in the increasing variety of different conditions that are coming under study using the tools of functional genomics.

描述（由申请人提供）：过去十年中全基因组研究的爆炸爆炸表明，需要新的范式，以将生物信息整合并传播到研究界的方式。因此，该提案的总体目标是设计和实施系统，使基因组数据集中包含的信息可能继续整合，包括至少基因表达，2杂交，合成的杀伤力和系统的缺失研究，并使整体信息可以通过研究社区访问，从而使研究社区最初创建糖类基因组合酶（DAT DAT DATED），并通过其他模型（SACCHAROMY DATABASE）（SACCHABASE）（SCCHABASE），以及SGD and sgd and sgd and sgd and sgd and sgd and sgd and Sgd），并可以通过SCD DATABD和SGD访问SGD，并可以通过SACD DATABD和SD DATABS，并可以通过SACD DATABD和SGD访问。适用系统并将其提交给通用模型生物数据库（GMOD）项目。我们设想，来自数据集中的信息将通过2个通用路线访问：首先，数据集成系统将是策展人评估有关基因功能的知识的指南，尤其是那些知之甚少的基因；其次，我们将继续将集成数据持续组织到可以直接查询的模式中。通过提供多种信息来源和以新的和更好的方式整合和查询它们的工具，我们旨在帮助生物学家在更全球的环境中逐步了解单个基因或感兴趣的途径。同样重要的是，我们希望通过使用功能基因组学的工具在研究中越来越多地研究的各种不同条件中的行为知识来增加对单个基因的生物学作用的了解。