Biostatistics, Modeling, and Data Management

生物统计学、建模和数据管理

基本信息

批准号：
8328986
负责人：
John R Votaw
金额：
$ 7.09万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8328986
关键词：
Basic Science Biometry Clinical Data Clinical Sciences Clinical Trials Collaborations Computer software Computers Confidentiality Consult Consultations Data Data Analyses Data Quality Data Storage and Retrieval Databases Development Ensure Future Goals Image Image Analysis Institutes Kinetics Malignant Neoplasms Manuscripts Measures Methodology Methods Modeling Molecular Monitor Performance Physiological Population Procedures Protocols documentation Quality Control Randomized Reporting Research Research Methodology Research Personnel Research Project Grants Research Proposals Resources Retrieval Sample Size Services Specific qualifier value Statistical Data Interpretation Statistical Models System Translational Research Writing base data management design innovation protocol development relational database research study tool

项目摘要

The purpose of the Biostatistics, Modeling, and Data Management Core (Core C) is to provide a comprehensive, multi-disciplinary resource for the design of all experiments, development of appropriate and innovative statistical methodology, development and application of appropriate kinetic models to intrepret the data, statistical analysis, and summarization of results. The Core has the following overall goals: to provide statistical and modeling consulting and collaboration on the design, conduct, analysis and interpretation of all project research studies and cores, and to provide, manage and maintain a high-quality research database that supports the research projects and cores while preserving the confidentiality of all subject data. The specific aims are to: (1) Coordinate and manage statistical activities to ensure investigators have ready access to statistical consultation and support. (2) Provide statistical expertise in the design of experiments and studies, including research proposal development, analysis methods, sample size determination, randomization procedures, and plans for interim reviews and final analysis. (3) Provide kinetic modeling expertice for all projects using imaging to measure physiologic parameters. (4) Provide data analysis and extraction to obtain the necessary information from project data. (5) Assist with the writing of statistical and modeling components of manuscripts. (6) Review the integrity and statistical soundness of all studies. (7) Maintain a computing facility with up-to-date software for statistical analysis to support all project investigators. (8) Conduct biostatistical methodology research on practical problems arising from performance of the projects. (9) Develop new modeling approaches as necessary to maximize the utility of each investigator's data. (10) Provide computer-based tools that facilitate the storage and retrieval of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (11) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (12) Organize and maintain the database to maximize accuracy and accessibility while maintaining strict confidentiality. (13) Provide detailed descriptions of the available populations and resources for current and future investigators. (14) Provide high-quality data entry services.

生物统计学，建模和数据管理核心（核心C）的目的是提供一个用于设计所有实验的全面，多学科资源，开发适当和创新的统计方法，开发和应用适当的动力学掩盖数据，统计分析和结果汇总的模型。核心有遵循总体目标：为设计提供统计和建模咨询和协作，对所有项目研究和核心进行，分析和解释，并提供，管理并维护支持研究项目和核心的高质量研究数据库保留所有主题数据的机密性。具体目的是：（1）协调和管理统计活动，以确保调查人员可以随时获得统计咨询和支持。（2）在设计和研究设计方面提供统计专业知识，包括研究建议开发，分析方法，样本量确定，随机程序和计划临时评论和最终分析。（3）使用成像为所有项目提供动力学建模专家测量生理参数。（4）提供数据分析和提取以获得必要的来自项目数据的信息。（5）协助编写统计和建模组件手稿。（6）回顾所有研究的完整性和统计声音。（7）维持一个使用最新软件来计算设施，用于统计分析，以支持所有项目调查人员。（8）进行生物统计学方法论研究，对性能的实践问题进行研究项目。（9）根据需要开发新的建模方法，以最大程度地提高每个建模的实用性研究者的数据。（10）提供基于计算机的工具，以促进存储和检索拟议的研究中产生的数据，从而创建和维护集中的关系提供对共同资源和信息的访问的数据库。（11）确保准确性通过基于软件的数据一致性和质量控制系统在数据库中维护的数据。（12）组织和维护数据库以最大程度地提高准确性和可及性，同时保持严格机密性。（13）提供当前可用人群和资源的详细描述和未来的调查人员。（14）提供高质量的数据输入服务。