Core C: Biostatistics, Modeling, and Data Management

核心 C：生物统计学、建模和数据管理

• 批准号: 7287008
• 负责人: John R Votaw
• 金额: $ 2.98万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7287008
• 关键词: Achievement; Arts; Basic Science; Biometry; Cancer Center; Clinical; Clinical Data; Clinical Trials; Collaborations; Computer Systems Development; Computer software; Computers; Confidentiality; Consult; Consultations; Data; Data Analyses; Data Collection; Data Quality; Data Security; Data Storage and Retrieval; Databases; Development; Ensure; Experimental Designs; Foundations; Future; Goals; Health Insurance Portability and Accountability Act; Image; Image Analysis; Imaging Techniques; Individual; Information Resources; Information Systems; Kinetics; Malignant Neoplasms; Manuscripts; Methodology; Methods; Modeling; Molecular; Monitor; Nature; Participant; Physics; Physiological; Pilot Projects; Population; Procedures; Protocols documentation; Publications; Purpose; Quality Control; Randomized; Regulation; Reporting; Research; Research Ethics Committees; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Retrieval; Role; Sample Size; Services; Specific qualifier value; Statistical Methods; Statistical Models; Structure; Support of Research; System; Testing; Translational Research; Variant; Writing; anticancer research; base; data management; design; expectation; in vivo Cellular and Molecular Imaging Centers; innovation; mathematical model; protocol development; research study; sound; statistics; tool

OVERVIEW The purpose of the Biostatistics, Modeling and Data Management Core (Core C) of the Emory Molecular and Translational Imaging Center (EMTIC) is to provide a comprehensive, multi-disciplinary resource for the design of clinical and basic science experiments, including statistical analysis, image analysis, and summarizing the results. The core has the following overall goal: to provide statistical and imaging protocol consulting and collaboration on the design, conduct, analysis and interpretation of all research studies and cores, and to provide, manage and maintain a high-quality research database that supports the projects and cores while preserving the confidentiality of all subject data. The specific aims are: (1) Provide quantitative image analysis, (2) Coordinate and manage statistical activities in the ICMIC to ensure investigators have ready access to statistical consultation and support. (3) Provide imaging protocol and statistical expertise in the design of experiments and studies, including research proposal development, specifying analysis methods, sample size determination, randomization procedures, and plans for interim reviews and final analysis. (4) Assist with the writing of image analysis and statistical components of manuscripts. (5) Review the integrity and statistical soundness of all studies. (6) Provide image analysis and statistical analysis for all projects using appropriate methodologies, and assist in the interpretation and presentation of results. (7) Interact and collaborate with the Clinical Trials and Translational Research Office in the development of protocols and monitoring and reporting of clinical data. (8) Maintain a computing facility for the purpose of extracting quantitative physiological information from the collected images. (9) Maintain a computing facility with up-todate software for statistical analysis. (10) Provide computer-based tools that facilitate the storage, retrieval, and viewing of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (11) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (12) Organize and maintain the database to maximize accuracy and accessibility; while maintaining strict confidentiality. (13) Provide detailed descriptions of the available populations and resources for current and future investigators. (14) Provide high-quality data entry services.

概述 Emory分子的生物统计学，建模和数据管理核心（核心C）的目的 和翻译成像中心（EMTIC）是为了为该公司提供全面的多学科资源 临床和基础科学实验的设计，包括统计分析，图像分析和 总结结果。核心具有以下总体目标：提供统计和成像协议 关于所有研究的设计，进行，分析和解释的咨询和协作 核心，并提供，管理和维护一个支持项目和支持项目的高质量研究数据库 核心保留所有主题数据的机密性。具体目的是：（1）提供定量 图像分析，（2）协调和管理ICMIC中的统计活动，以确保研究人员拥有 准备访问统计咨询和支持。 （3）提供成像协议和统计专业知识 实验和研究的设计，包括研究建议开发，指定分析方法， 样本量确定，随机化程序以及临时审查和最终分析的计划。 （4） 协助撰写图像分析和手稿的统计组成部分。 （5）审查完整性 和所有研究的统计健全性。 （6）使用 适当的方法，并协助解释和表现结果。 （7）互动和 与临床试验和转化研究办公室合作，以制定协议和 监测和报告临床数据。 （8）维护计算设施以提取 来自收集图像的定量生理信息。 （9）维护一个以上的计算设施 用于统计分析的软件。 （10）提供基于计算机的工具，可促进存储，检索， 并查看拟议研究中产生的数据，从而创建和维护集中式 关系数据库，可访问公共资源和信息。 （11）确保准确性 通过基于软件的数据一致性和质量控制系统在数据库中维护的数据。 （12） 组织和维护数据库，以最大程度地提高准确性和可访问性；同时保持严格 机密性。 （13）提供有关当前可用人群和资源的详细描述 未来的调查人员。 （14）提供高质量的数据输入服务。