Center for Molecular Epidemiology

分子流行病学中心

• 批准号: 9001341
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 228.96万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001341
• 关键词: Achievement; Address; Advisory Committees; Arts; Basic Science; Biology; Biomedical Research; Centers of Research Excellence; Chemoprevention; Clinical; Complement; Department chair; Development; Disease; Disease Pathway; Emerging Technologies; Ensure; Epidemiologic Studies; Epidemiologist; Epidemiology; Epigenetic Process; Etiology; Evaluation; Faculty; Faculty Recruitment; Fostering; Funding; Future; Genetic; Goals; Grant; Health; Human; Immunology; Investigation; Lead; Longevity; Maine; Malignant Neoplasms; Measures; Medical center; Mentors; Mentorship; Metagenomics; Methodology; Methods; Molecular; Molecular Epidemiology; Monitor; New England; New Hampshire; Norris Cotton Cancer Center; Outcome; Pathogenesis; Pharmacology and Toxicology; Physicians; Positioning Attribute; Prevention; Principal Investigator; Public Health; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Science; Scientist; Senior Scientist; Staging; Statistical Computing; Structure; Technology; Trace Elements; Translating; Translations; United States National Institutes of Health; Vermont; biobank; bioimaging; burden of illness; career; career development; college; experience; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; population based; prevent; programs; public health relevance; research and development; tenure track; Achievement; Address; Advisory Committees; Arts; Basic Science; Biology; Biomedical Research; Centers of Research Excellence; Chemoprevention; Clinical; Complement; Department chair; Development; Disease; Disease Pathway; Emerging Technologies; Ensure; Epidemiologic Studies; Epidemiologist; Epidemiology; Epigenetic Process; Etiology; Evaluation; Faculty; Faculty Recruitment; Fostering; Funding; Future; Genetic; Goals; Grant; Health; Human; Immunology; Investigation; Lead; Longevity; Maine; Malignant Neoplasms; Measures; Medical center; Mentors; Mentorship; Metagenomics; Methodology; Methods; Molecular; Molecular Epidemiology; Monitor; New England; New Hampshire; Norris Cotton Cancer Center; Outcome; Pathogenesis; Pharmacology and Toxicology; Physicians; Positioning Attribute; Prevention; Principal Investigator; Public Health; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Science; Scientist; Senior Scientist; Staging; Statistical Computing; Structure; Technology; Trace Elements; Translating; Translations; United States National Institutes of Health; Vermont; biobank; bioimaging; burden of illness; career; career development; college; experience; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; population based; prevent; programs; public health relevance; research and development; tenure track

DESCRIPTION (provided by applicant): We proposed to establish a sustainable Center of Biomedical Research Excellence (COBRE) in Molecular Epidemiology at Dartmouth structured to support the recruitment, career development, and engagement of talented junior investigators who will advance their research in molecular epidemiology as part of the new Center. We will bring together a diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns, and ultimately inform clinical decision and practice change. Faculty will span multiple departments in Dartmouth Medical School, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. Dartmouth Medical School has a long and distinguished tradition in epidemiology having conducted the first NIH funded chemoprevention trial of cancer in the early 1980s, and numerous population based studies to illuminate the pathogenesis of major health outcomes. Extending this tradition with strong support from Dartmouth will position us to serve as a vital resource in molecular epidemiology for northern New England and for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs nationally. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along with a state-of-the-art, multidisciplinary Biorepository Core and vibrant Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to establish this new Center over the next five years with the goals of: 1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan.

描述（由申请人提供）：我们提议建立达特茅斯分子流行病学的可持续生物医学研究中心（COBRE），该中心旨在支持才华横溢的初级调查人员的招聘，职业发展和参与，他们将推进他们作为新中心的一部分分子流行病学研究的研究。我们将汇集一位多元化的教师，并在整合和翻译前沿科学技术和发现方面具有共同的兴趣，以提高我们对主要人类健康问题的理解，并最终为临床决策和实践变化提供依据。教师将跨越达特茅斯医学院，达特茅斯希区柯克医学中心和达特茅斯艺术与科学学院的多个部门。达特茅斯医学院在流行病学方面具有悠久而杰出的传统，在1980年代初进行了第一次NIH资助的癌症化学预防试验，并进行了许多基于人群的研究，以阐明主要健康结果的发病机理。在达特茅斯（Dartmouth）的大力支持下扩展这一传统将使我们成为新英格兰北部分子流行病学的重要资源，以及在全国范围内的生物医学研究卓越研究（INBRE）计划的索布雷和思想网络。据我们所知，新英格兰没有其他分子流行病学的学术中心，或者目前在全国范围内以分子流行病学为重点的Cobres。作为拟议的毛病的一部分，我们将提供关键的分子流行病学研究基础设施，可以利用创新方法，并可以翻译新的发现。这将通过四个独立的研究项目以及紧密交织的主题以及最先进的，多学科的生物座位核心以及充满活力的行政，职业发展和研究整合核心来实现。在新罕布什尔州分子流行病学的日益增长的基础上，我们准备在未来五年内建立这个新中心，其目标：1）刺激严格的创新研究并促进初级研究人员的职业发展，并招募新教师的职业发展，2）2）促进人类疾病的策略和进步策略，并促进了疾病的策略，并促进了疾病的策略，以及3岁的进步，以及3），3）寿命。