INTERGRATIVE HEALTH SCIENCES CORE

综合健康科学核心

• 批准号: 8279269
• 负责人: Edward Avol
• 金额: $ 63.53万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279269
• 关键词: Air Pollution; Biometry; Carotid Arteries; Cells; Characteristics; Child; Cohort Studies; Collection; Communities; Community Relations; Computers; Core Facility; Data; Data Collection; Documentation; Enrollment; Equilibrium; Exhalation; Feedback; Genes; Genetic; Genetic Materials; Health; Health Sciences; Health Status; Human Resources; Individual; Informed Consent; Interview; Legal Guardians; Location; Logistics; Maintenance; Measurement; Molecular Biology; Nature; Nitric Oxide; Parents; Performance; Population; Population Study; Pulmonary function tests; Quality Control; Questionnaires; Research; Research Personnel; Research Project Grants; Resources; Sampling; Schools; Self-Administered; Specimen; Spirometry; Study Subject; Symptoms; System; Testing; Thick; Training; Update; Work; Writing; base; cohort; computerized; data management; improved; operation; programs; quality assurance; respiratory; volunteer; young adult

The Integrative Health Sciences Core (IHSC) is central to the successful completion of the program of research proposed in this renewal. IHSC activities expand the previous scope of work of the Field Operations Core in the original P01 by maximizing project coordination and efficiency. This will be accomplished by centralizing all aspects of school and community relations, subject contact, health data collections and cohort maintenance. The complementary nature of the proposed projects and the synergy achieved from utilizing the same volunteer subject population and community air pollution sampling locations for all three projects provide a common basis for consolidation of complementary field support efforts. The integrative coordination provided by the IHSC will reduce the need for repetitive subject contacts required to accomplish the aims of the three projects in the renewal P01, establish a unified and efficient updating system for subject tracking and facilitate streamlined and coordinated interactions with study subjects, all of which are required for successful cohort studies. Subject recruitment for various programmatic sub-studies will be overseen by the IHSC to balance scientific requirements and research needs with subject access and necessary research documentation. The IHSC will collect health information needed in the study projects (including individual personal computerized interview, maximal exhaled spirometry, self-administered questionnaires and additional genetic material for gene/environmental array analyses). The IHSC will coordinate efforts with complementary data collection activities being performed on the same study subjects for other ongoing projects, such as the off-line or realtime collection of exhaled nitric oxide and the non-invasive measurement of carotid artery thickness. This will permit timely subject interactions, make better use of limited field staff and reduce subject and school inconveniences. The core will also facilitate coordinated interactions with the Biostatistics and Data Management Core in managing data and providing prompt feedback on study performance and quality assurance activities. Additionally, the IHSC will provide a centralized contact point for each of the projects and facility cores such as the Molecular Biology Core in the SCEHSC. Finally, a centralized approach to providing for project data collection under the oversight of a single core led by one investigator with over-arching coverage of, commitments to and relationships with each of the projects will improve overall P01 efficiency.

综合健康科学核心（IHSC）是成功完成该计划的核心 在此续约中提出的研究。 IHSC活动扩大了现场操作的先前工作范围 原始P01中的核心通过最大化项目协调和效率。这将通过 集中学校和社区关系的所有方面，主题联系，健康数据收集和队列 维护。拟议项目的互补性以及利用该项目实现的协同作用 所有三个项目提供的相同的志愿者人群和社区空气污染抽样地点 巩固互补现场支持工作的共同基础。综合协调 由IHSC提供的将减少对实现目标的重复主题联系的需求 续签P01中的三个项目，建立一个统一，高效的更新系统，用于主题跟踪和 促进与研究对象的简化和协调的互动，所有这些都是成功的 队列研究。 IHSC将监督各种程序化子研究的主题招聘，以平衡科学 要求和研究需求，并具有主题访问和必要的研究文档。 IHSC会 收集研究项目中需要的健康信息（包括个人计算机化访谈， 最大呼出的肺活量测定法，自我管理问卷和其他遗传材料 基因/环境阵列分析）。 IHSC将与互补数据收集协调工作 针对其他正在进行的项目（例如离线或实时）的研究主题进行的活动 收集呼出的一氧化氮和颈动脉厚度的非侵入性测量。这会 允许及时的主题互动，更好地利用有限的现场人员并减少学科和学校 不便。核心还将促进与生物统计学和数据的协调相互作用 管理核心管理数据并提供有关研究绩效和质量的及时反馈 保证活动。此外，IHSC将为每个项目提供集中的联系点， 设施核心，例如SCEHSC中的分子生物学核心。最后，一种集中的方法 对于由一个调查员领导的单一核心的监督下的项目数据收集 对每个项目的承诺，承诺和关系的覆盖范围将提高整体P01效率。