Environmental Factors in Cardiovascular Disease

心血管疾病的环境因素

基本信息

批准号：
8462602
负责人：
Joel Daniel Kaufman
金额：
$ 14.1万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8462602
关键词：
Acetylcysteine Acute Address Air Air Pollutants Air Pollution Antioxidants Atherosclerosis Attenuated Award Biometry Blood Vessels Breathing Caliber Carbon Black Cardiology Cardiovascular Diseases Cardiovascular system Carotid Arteries Chronic Clinical Collaborations CpG Islands DNA Methylation Data Analyses Databases Diesel Exhaust Discipline Endothelin-1 Environmental Engineering technology Environmental Health Environmental Medicine Environmental Risk Factor Epidemiologic Studies Epidemiology Exposure to Funding Genes Genetic Polymorphism Genome Goals Grant Health Homeostasis Hour Human Hygiene Incidence Individual Inflammation Intention Interleukin-6 Joints Kinetics Left Long-Term Effects Measures Medial Mediating Mediator of activation protein Medical Students Mentors Mentorship Methylation Mid-Career Clinical Scientist Award (K24)Modeling Morbidity - disease rate NIH Program Announcements Occupational Occupational Medicine Oxidative Stress Participant Particulate Particulate Matter Pathway interactions Plasma Play Pollution Prevalence Productivity Public Health Public Policy Pulmonology Receptor, Angiotensin, Type 1 Research Research Activity Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Resolution Resources Retinal Role Sampling Site Source Specific qualifier value Staging Structure Students Supplementation Thick Time Toxicology Training Training Programs Translational Research Ultrasonography Universities Vascular System Washington X-Ray Computed Tomography ascorbate base cardiovascular disorder epidemiology clinical practice cohort coronary artery calcification cytokine epigenomics exposed human population graduate student health science research monocyte mortality patient oriented patient oriented research pollutant population based programs prospective public health relevance research study success time use trafficking translational approach vasoconstriction

项目摘要

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences.

描述（由申请人提供）这项拟议的中级研究员奖的目标是扩大针对华盛顿大学环境健康科学的多学科研究的培训。通过与几个正在进行的培训计划的合作，候选人，MD，MPH的Joel D. Kaufman将与来自几个相关学科的受训者一起扩展一项广泛的研究计划和指导计划。在最初的K24奖项期间，考夫曼博士的研究生产力和指导提高和加速了深度和广度。该持续的计划将整合实验性，流行病学和转化方法，以解决环境因素在心血管疾病中的作用。拟议的研究是Kaufman博士正在进行的研究计划的两个主题相关项目的结合。两者都解决了与交通相关的空气污染通过急性和慢性影响血管系统对心血管疾病产生影响的论点。一个项目研究柴油排气吸入对受控暴露中血管功能的影响，以解决机械假设以了解氧化应激的作用。第二个项目基于对空气污染对心血管疾病的影响的流行病学研究，并研究了基于多种族的基于多种族的人群的急性和慢性污染暴露对血管功能，动脉粥样硬化和表观基因组标志物的关节和独立影响。这项指导计划基于考夫曼博士在多学科研究方面的成功，并旨在为以患者为导向的环境健康科学研究提供研究指导，向来自各种学科的受训者提供研究。这些将包括职业和环境医学，心脏病学和肺部医学的研究员；医学生；以及流行病学，毒理学，职业和环境卫生，生物统计学和环境工程的研究生。该计划将包括研究基础设施（研究援助，数据分析和生物统计学）和监督研究指导。华盛顿大学为环境健康科学领域的合作培训和以患者为导向的研究提供了出色的环境。