Functional microcircuitry underlying sound processing in the primary auditory cor

初级听觉神经中声音处理的功能微电路

基本信息

批准号：
8302391
负责人：
ANTHONY M ZADOR
金额：
$ 35.43万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-01-23 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8302391
关键词：
Accounting Acoustic Nerve Acoustic Stimulation Acute Area Auditory Auditory area Auditory system Autistic Disorder Behavior Brain Characteristics Complex Diagnosis Disease Epilepsy Equilibrium Etiology Goals Grant In Vitro Individual Interneurons Investigation Lead Link Mediating Mental disorders Methods Molecular Molecular Profiling Monitor Nervous system structure Neurons Parvalbumins Pattern Physiological Physiology Play Population Positioning Attribute Preparation Process Property Rattus Relative (related person)Reporting Rodent Role Schizophrenia Sensory Shapes Slice Synapses Techniques Testing Tinnitus Visual Cortex Work area V1 awake base extrastriate visual cortex improved in vivo inhibitory neuron millisecond nervous system disorder neural circuit neuromechanism neuronal circuitry neuropathology receptive field relating to nervous system response sensory cortex sensory neuroscience sensory stimulus sound therapy development tool

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of our investigations is to understand the functional role of certain neuronal subtypes in the processing of sound in the cortex. Understanding this circuitry is likely to have an impact on the diagnosis and treatment of clinically important cortical neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. Our central hypothesis is that a certain subtype of inhibitory neuron plays an important role in determining how other cortical neurons respond to sound. To achieve our goals, we propose to monitor and perturb the activity of these neurons. In aim 1, we will study this circuit in vitro, substituting electrical for auditory stimulation. In aims 2 and 3 we will study this circuit in vivo, presenting simple sounds and monitoring the responses they elicit in single neurons, and looking at their role in an auditory behavior. If successful, our studies will provide the link between molecular, circuit and functional aspects of sound processing in the auditory system, and will facilitate the development of treatments for psychiatric and neurological diseases. This proposal will test the function of a particular class of cortical neurons implicated in the etiology of clinically important neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders.

描述（由申请人提供）：我们调查的长期目标是了解某些神经元亚型在皮质中声音处理中的功能作用。了解该电路可能会影响临床上重要的皮质神经病理学的诊断和治疗，包括自闭症，精神分裂症，耳鸣和癫痫。我们的中心假设是，某种抑制性神经元的亚型在确定其他皮质神经元如何反应声音方面起着重要作用。为了实现我们的目标，我们建议监测和扰动这些神经元的活动。在AIM 1中，我们将在体外研究该电路，用电气代替听觉刺激。在AIMS 2和3中，我们将在体内研究该电路，呈现简单的声音并监视它们在单个神经元中引起的反应，并查看它们在听觉行为中的作用。如果成功，我们的研究将提供听觉系统中声音处理的分子，电路和功能方面之间的联系，并促进精神病和神经系统疾病的治疗方法的发展。该建议将测试与临床上重要的神经病理学病因有关的特定类型的皮质神经元的功能，包括自闭症，精神分裂症，耳鸣和癫痫。如果成功，我们的研究将导致改善诊断和治疗这些疾病的策略。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Representations in auditory cortex.

DOI：
10.1016/j.conb.2009.07.009
发表时间：
2009-08
期刊：
Current opinion in neurobiology
影响因子：
5.7
作者：
Hromádka T;Zador AM
通讯作者：
Zador AM

PTEN regulation of local and long-range connections in mouse auditory cortex.

DOI：
10.1523/jneurosci.4480-11.2012
发表时间：
2012-02-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Xiong Q;Oviedo HV;Trotman LC;Zador AM
通讯作者：
Zador AM

Up states are rare in awake auditory cortex.

在清醒的听觉皮层中，向上状态很少见。