Circuit mechanisms of auditory categorization

听觉分类的电路机制

基本信息

批准号：
8721392
负责人：
ANTHONY M ZADOR
金额：
$ 40.16万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8721392
关键词：
Animals Architecture Area Auditory Auditory area Auditory system Autistic Disorder Behavior Behavioral Brain region Chronic Corpus striatum structure Decision Making Diagnosis Disease Environment Etiology Foundations Gilles de la Tourette syndrome Goals Human Investigation Laboratories Language Lead Learning Left Mediating Mental disorders Methods Modality Molecular Neural Pathways Neurons Obsessive-Compulsive Disorder Output Parkinson Disease Pathway interactions Perception Positioning Attribute Process Rattus Rewards Rodent Role Schizophrenia Sensory Signal Transduction Stimulus Testing Tinnitus Training auditory stimulus awake design extracellular flexibility improved insight nervous system disorder neural circuit neuromechanism neuropathology nonhuman primate optogenetics research study response sound therapy development tool

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of our investigations is to understand how neural circuits in the auditory system underlie the processing of sound. Understanding this circuitry is likely to have an impact on the diagnosis and treatment of clinically important central neuropathologies, including autism, schizophrenia, tinnitus, Tourette's syndrome and obsessive compulsive disorder. The central goal of this proposal is to understand how the output of the auditory cortex is used by downstream areas to effect behavior. In Aim 1 we use electrophysiological methods to study responses in the auditory cortex and target areas during a sound categorization task. In Aim 2 we use optogenetic methods to test the hypotheses that the activity of output neurons in the auditory cortex is causal in mediating behavior during the task. Finally in Aim 3, we test the hypothesis that learning to perform an auditory categorization modifies connections between neurons in their auditory cortex and their downstream targets. These studies will provide insight into how auditory cortex guides behavior, and provide a foundation for further study of role of these neurons in normal auditory function and disease, facilitating the development of treatments for psychiatric and neurological diseases.

描述（由申请人提供）：我们调查的长期目标是了解听觉系统中的神经回路如何处理声音的处理。了解该电路可能会影响临床上重要的中枢神经病理学的诊断和治疗，包括自闭症，精神分裂症，耳鸣，图雷特综合症和强迫症。该提案的核心目标是了解下游区域如何使用听觉皮层的输出来实现行为。在AIM 1中，我们使用电生理方法在声音分类任务中研究听觉皮层和目标区域的反应。在AIM 2中，我们使用光遗传学方法来检验假设，即在任务过程中，听觉皮层中输出神经元的活性是介导行为的原因。最终，在AIM 3中，我们检验了以下假设：学习执行听觉分类会修改其听觉皮层中神经元与其下游目标之间的连接。这些研究将提供有关听觉皮层如何指导行为的洞察力，并为这些神经元在正常听觉功能和疾病中的作用进一步研究提供了基础，从而促进了精神病和神经系统疾病的治疗方法的发展。