SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用

• 批准号: 8323219
• 负责人: Kenneth D. Tew
• 金额: $ 218.17万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323219
• 关键词: Aging; Area; Award; Biological; Biomedical Research; Businesses; Calpain; Cardiovascular Diseases; Cell Death; Cells; Centers of Research Excellence; Collaborations; Cytoprotection; Development; Diabetes Mellitus; Discipline; Disease; Environment; Equilibrium; Etiology; Faculty; Fellowship; Fostering; Funding; Future; Goals; Grant; Growth and Development function; Human Pathology; Individual; Inflammation; Injury; Ischemia; Joints; Journals; Laboratories; Laboratory Research; Link; Malignant Neoplasms; Medical; Mentors; Mentorship; Mitochondria; Molecular; Motivation; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Nitrogen; Outcome; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Participant; Pathology; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Pharmacy facility; Positioning Attribute; Post-Translational Protein Processing; Postdoctoral Fellow; Program Development; Proteins; Proteomics; Radiation; Recording of previous events; Recruitment Activity; Reperfusion Therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Support; Research Technics; Resources; Science; Scientist; Signal Pathway; Signal Transduction; Source; South Carolina; Stress; Therapeutic; Training; United States National Institutes of Health; Universities; Xenobiotics; cancer initiation; carcinogenesis; career; career development; cellular imaging; college; doctoral student; drug development; drug discovery; experience; gene therapy; graduate student; interest; member; metabolomics; molecular imaging; neuron loss; novel therapeutics; pre-doctoral; programs; research and development; response; small molecule; success; toxicant

This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise

该鞋底计划旨在将南卡罗来纳州医科大学的氧化剂，氧化还原平衡和压力信号的现有专业知识的个人汇集在一起​​。我们的长期计划是在南卡罗来纳州发展这个科学学科或科学重点的卓越中心。为此，我们构建了一个基础设施，该基础设施将为五个目标教师提供cal和糖尿病信号途径的研究兴趣，线粒体中的氧化途径，反应性氧（ROS）和氮（RNS）和过氧蛋白的氧化途径和氧化蛋白的氧化蛋白和氧化蛋白的氧化蛋白和氧化蛋白质的氧化蛋白和氧化蛋白质的氧化蛋白和氧化蛋白。他们的项目提供了跨学科的机会，并得到了蛋白质组学，代谢组学和细胞和分子成像的三个科学核心的支持。中心假设是氧化还原调节的途径对癌症，衰老，糖尿病，炎症和神经变性等疾病的病理生物学显着影响。行政核心将促进众多功能，包括业务管理，教职员工发展，指导和计划计划和可持续性。我们已任命监督委员会，包括转向，内部顾问和外部顾问。后两个小组包含在所选学科和广泛的指导经验方面具有广泛科学专业知识的个人。 MUSC财政支持以及创建新的和翻新的空间，该计划的未来发展也将允许具有互补专业知识的其他教师招聘