Division of Chemical Toxicology Symposia at the 266th National ACS Meeting

第266届全国ACS会议化学毒理学研讨会分部

• 批准号: 10753870
• 负责人: Michael A Trakselis
• 金额: $ 0.8万
• 依托单位: BAYLOR UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-16 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753870
• 关键词: Academia; Affect; Aging; American; Area; Artificial Intelligence; Award; Biochemistry; Biology; Chemical Exposure; Chemical Models; Chemicals; Chemistry; Collaborations; Communication; Communities; Complement; Data; Disease; Disparity; Drug Interactions; Drug toxicity; Environmental Health; Faculty; Fostering; Funding; Goals; Health; Human; Industrialization; Industry; Journals; Knowledge; Leadership; Learning; Link; Measures; Metabolism; Mission; Molecular; National Institute of Environmental Health Sciences; Oral; Outcome; Pharmaceutical Chemistry; Pharmaceutical Preparations; Policies; Postdoctoral Fellow; Process; Publishing; Research; Research Methodology; Research Personnel; Role; San Francisco; Scientist; Societies; Students; System; Testing; Toxic effect; Toxicology; Travel; United States National Institutes of Health; Vulnerable Populations; Writing; career; career development; drug efficacy; environmental agent; environmental chemistry; graduate student; improved; in vitro Model; interest; medical specialties; meetings; member; novel; organ growth; organ on a chip; posters; programs; response; skill acquisition; student mentoring; symposium; welfare

Project Summary/Abstract The goal of this application is to obtain support for the American Chemical Society Division of Chemical Toxicology (TOXI) at the 266th 2023 National Meeting program, which will be held August 13-17, 2023, in San Francisco, CA. The mission of the Division of Chemical Toxicology is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. Our goals include providing a forum for communicating research in the field of chemical toxicology, encouraging research in chemical mechanisms of toxicity, and facilitating connections between academia, industry, and policy in scientific areas of mutual interest. We are also committed to developing the leadership and professional development skills of scientists at all levels. Thus, the requested funds will be used to support travel awards and expenses for graduate students, postdoctoral scholars, and junior faculty. The overall TOXI program is organized around the theme of “Toxicological Predictions, Markers, and Outcomes Affecting Human Health” and complements the National Meeting theme of Harnessing the Power of Data. The program includes five thematic symposia, which will feature invited oral presentations by a diverse group of established and emerging investigators with a range of perspectives on each topic. The five thematic symposia are: (1) “Application of Augmented Artificial Intelligence in Toxicology Metabolism Prediction”, co-promoted by the Divisions of Chemical Information (CINF) and Medicinal Chemistry (MEDI), will explore the role of augmented AI in predicting toxic metabolites; (2) “Toxicity & Drug-Drug Interactions Resulting from Inhibition of Transporters”, co-promoted with MEDI, will examine the impact of inhibiting transporters to regulate drug efficacies; (3) “Advanced in vitro Models for Chemical Toxicity,” co-promoted with MEDI, focuses on recent progress in development of organ-on-chip systems on testing chemical toxicity; (4) “Linking Toxicology and Human Health Through the Exposome”, copromoted with the Divisions of Biological Chemistry (BIOL) and Environmental Chemistry (ENVR), describes recent advances in measuring lifetime of chemical exposures and disparities in vulnerable populations; and (5) “Endogenous Metabolites in Aging and Disease”, copromoted with BIOL, focuses on the chemistry and biology that underly cellular responses to misregulated formation of endogenous metabolites. The scientific program is clearly aligned with the mission of NIEHS.

项目摘要/摘要 该应用的目的是获得对美国化学化学学会的支持 毒理学（TOXI）在2023年266号全国会议计划上，该计划将于2023年8月13日至17日在 加利福尼亚州旧金山化学毒理学措施的使命是改善人类健康和 通过促进对疾病过程的化学机制的理解和公共福利 药物，环境药物和内源性化学物质的毒性。我们的目标包括提供 在化学毒理学领域进行交流研究论坛，鼓励化学研究 毒性机制，并支持学术，行业和科学政策之间的联系 共同感兴趣的地区。我们还致力于发展领导力和专业发展 各级科学家的技能。那就是，要求的资金将用于支持旅行奖和 研究生，博士后学者和初级教师的费用。总体Toxi程序是 围绕“毒理学预测，标记和影响人类健康的结果”的主题组织 并符合利用数据力量的全国会议主题。该程序包括 五个主题研讨会将由一系列已建立和 新兴的调查人员对每个主题都有一系列观点。五个主题研讨会是：（1） “增强人工智能在毒理学代谢预测中的应用”，由 化学信息（CINF）和药物化学（MEDI）的划分将探讨 增强AI预测有毒代谢产物； （2）“抑制作用引起的毒性和药物相互作用 与MEDI共同宣传的转运蛋白”将检查抑制转运蛋白调节药物的影响 效果； （3）与MEDI共同促进的“化学毒性的高级体外模型”，重点是最近 芯片系统测试化学毒性的开发进展； （4）“联系毒理学和 通过杂物体的人类健康”，与生物化学（Biol）和 环境化学（ENVR）描述了测量化学暴露寿命的最新进展 脆弱人群的差异； （5）“衰老和疾病中的内源代谢产物”， 与生物体共同覆盖，着重于化学和生物学，这些化学和生物学是基本的细胞反应 内源代谢产物的形成不当。科学计划显然与 Niehs的任务。