South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用

• 批准号: 10674956
• 负责人: Kenneth D. Tew
• 金额: $ 113.25万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674956
• 关键词: Abbreviations; Accountability; Achievement; Advisory Committees; Analytical Biochemistry; Area; Automobile Driving; Award; Bioenergetics; Biology; Biomedical Research; Biotechnology; Cancer Center; Cardiovascular Diseases; Cells; Centers of Research Excellence; Collaborations; Complement; Core Facility; Diabetes Mellitus; Discipline; Disease; Drug Addiction; Economics; Engineering; Equilibrium; Equipment; Extramural Activities; Faculty; Financial Support; Fostering; Funding; Gastrointestinal Agents; Gastrointestinal Diseases; Goals; Grant; Growth; Health; Homeostasis; Human; Human Pathology; Image; Individual; Infrastructure; Institution; Interdisciplinary Study; Intervention; Malignant Neoplasms; Mass Spectrum Analysis; Medical; Medicine; Mentors; Metabolic dysfunction; Mission; Modeling; Molecular; Musculoskeletal; National Institute of General Medical Sciences; Neurodegenerative Disorders; Organism; Oxidants; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Oxygen; Paper; Pathologic; Pathway interactions; Peer Review; Phase; Pilot Projects; Positioning Attribute; Proteomics; Published Comment; Publishing; Recovery; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Role; Scientific Advances and Accomplishments; Secure; Services; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Source; South Carolina; Stress; Talents; Teacher Professional Development; Therapeutic; Tissues; Toxic effect; Training; Translational Research; United States National Institutes of Health; Universities; Workforce Development; base; career; collaborative environment; college; commercial application; cost; design; experience; faculty support; human disease; imaging capabilities; improved; infrastructure development; mass spectrometric imaging; member; microscopic imaging; multi-photon; multidisciplinary; new technology; novel; outreach; programs; recruit; success; targeted treatment; translational goal; ultra high resolution

Overall – Abstract With Phase III COBRE support, the South Carolina Center in Oxidants, Redox Balance, and Stress Signaling (Redox COBRE) at the Medical University of South Carolina (MUSC) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in redox pathobiology. During Phases I and II, our Redox COBRE was successful in its efforts to (i) expand the critical mass of funded investigators at MUSC studying the causal role of redox pathways and metabolic dysfunction in a wide range of human pathologies (cancer, cardiovascular and neurodegenerative diseases, diabetes, gastrointestinal disorders and drug addiction) and (ii) develop advanced scientific core resources offering a broad range of capabilities for investigating the biologically significant effects of oxidative stress. Our current core membership comprises 44 senior and junior faculty members that have received more than $51 million in awards since the program’s inception. To date, the Redox COBRE has mentored a total of 20 target faculty (junior investigators + pilot project-supported PIs). Of these individuals, 10 have been promoted and 16 have been retained at our institution. As a group, these faculty members have published more than 250 peer-reviewed papers and secured 56 extramural grant awards (including 31 NIH grants (PI role) of which 16 are R01 awards and 8 are SBIR/STTR- supported start-ups). The major components of this Phase III proposal are: (1) an Administrative Core providing organizational, coordinating, fiscal and accountability functions; (2) an Analytical Redox Core delivering analytical biochemistry services for quantification of redox-sensitive molecule abundance and redox-based changes in cellular homeostasis; (3) a Proteomics Core that offers state-of-the-art mass spectrometry (MS) and MS-imaging capabilities; (4) a Cell & Molecular Redox Imaging Core that provides cell and tissue-based confocal, multiphoton and super-resolution microscopic imaging; and (5) a Pilot Projects Program (PPP) that fosters research endeavors utilizing Center resources and facilitates collaborations with Redox COBRE members. Towards our objective of becoming a stand-alone Center of Redox Biology and Signaling (abbreviated to “Redox Center”), we will build upon our substantial scientific and institutional achievements, to: (Aim 1) enhance the function and efficiencies of our scientific cores, achieving optimal positioning to serve Center thematic and translational goals and achieve/ maintain sustainability; (Aim 2) leverage the PPP to grow center membership and promote the importance of translational redox signaling research in the context of human disease; (Aim 3) develop the research portfolio and connections between the Redox COBRE and other IDeA programs to establish ourselves as a national presence coalescing various disciplines and areas of expertise. Thus, we are seeking to establish a strategic position for long-term success as an emergent, University- designated Redox Center that will be one of few national resources for investigators to utilize or develop new technologies, therapeutics and interventions targeting pathological redox pathways.

总体 - 抽象 在III期毛线支撑剂的情况下，南卡罗来纳州的氧化剂中心，氧化还原平衡和应力信号传导 （氧化还原柯布雷）在南卡罗来纳州医科大学（MUSC）将完成其长期过渡 可持续性是氧化还原病理生物学领域具有全国竞争性的多学科研究计划。期间 第一阶段和第二阶段，我们的氧化还原杂种在（i）扩大资助的临界质量方面取得了成功 MUSC研究人员研究了氧化还原途径和代谢功能障碍的因果关系。 人体病理（癌症，心血管和神经退行性疾病，糖尿病，胃肠道 疾病和吸毒成瘾）和（ii）开发高级科学核心资源，提供广泛的范围 研究氧化应激的生物学显着效应的能力。我们目前的核心会员资格 自从获得超过5100万美元的奖项以来，有44名高级和初级教职员工 计划的成立。迄今为止，氧化还原圆锥被称为20个目标教职员工（初级研究人员 + 飞行员项目支持的PI）。在这些人中，有10个已被提升，并保留了16人 机构。作为一个小组，这些教职员工发表了250多个同行评审的论文并获得了确保 56个校外授予奖（包括31个NIH赠款（PI角色），其中16个是R01奖项，8个是SBIR/STTR- 支持的初创企业）。该第三阶段提案的主要组成部分是：（1）行政核心提供 组织，协调，财政和问责制； （2）分析氧化还原芯输送 分析生物化学服务，用于量化氧化还原敏感的分子丰度和基于氧化还原的分子 细胞稳态的变化； （3）提供最先进的质谱法（MS）和的蛋白质组学核心 MS成像功能； （4）提供基于细胞和组织的细胞和分子氧化还原成像核 共聚焦，多光子和超分辨率微观成像； （5）试点项目计划（PPP） 利用中心资源并促进与氧化还原的合作促进研究努力 成员。我们的目标是成为氧化还原生物学和信号传导的独立中心（缩写） 为了“氧化还原中心”），我们将在我们的实质科学和机构成就的基础上进行：（目标1） 提高我们科学核心的功能和效率，实现最佳定位以服务中心 主题和翻译目标并实现/维持可持续性； （目标2）利用PPP发展中心 在人类的背景下，会员资格并促进翻译的氧化还原信号研究的重要性 疾病; （目标3）开发研究组合和氧化还原毛绒与其他想法之间的联系 将自己确立为全国性的计划，结合了各种学科和专业知识领域。 这是，我们正在寻求建立一个长期成功的战略立场，这是一所新兴的大学 - 指定的氧化还原中心将是调查人员使用或开发新的国家资源之一 针对病理氧化还原途径的技术，治疗和干预措施。