Peptide Core

肽核心

基本信息

批准号：
8324708
负责人：
CHUNG OWYANG
金额：
$ 4.13万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8324708
关键词：
Amino Acids Bacteriophages Binding C-Peptide Cell Surface Receptors Cell surface Clinical Consultations Core Facility Custom Databases Detection Development Digestive System Disorders Doctor of Philosophy Dyes Dysplasia Epitopes Experimental Designs Fingerprint Fluorescence Funding Gastroenterology Gastrointestinal tract structure Gene Chips Gene Targeting Human Investigation Label Life Mass Spectrum Analysis Michigan Mission Molecular Molecular Weight Mucous Membrane National Institute of Diabetes and Digestive and Kidney Diseases Neoplasms Neoplastic Cell Transformation Peptide Synthesis Peptides Phage Display Premalignant Preparation Property Proteins Proteomics Research Research Personnel Resources Sampling Screening procedure Services Signal Transduction Techniques Training and Education Transgenic Animals United States National Institutes of Health Universities animal model development cell fixing experience in vivo protein aminoacid sequence protein structure

项目摘要

Core C: Peptides - The overall mission of the Peptide Core is to provide the resources and services needed to select, screen, sequence, synthesize, label, and analyze the peptides to be used in the Primary and Task Specific Projects for preferential binding and detection of dysplasia in the gastrointestinal tract. Chung Owyang, MD is the Director of Core C: Peptides for this proposed NTR Research Center. Dr. Owyang is also the P.I. of the Gastroenterology Peptide Research Core Center at the University of Michigan, an NIH/NIDDK funded Digestive Disease Center whose mission is to investigate the functional properties and signaling mechanisms of gut peptides. He provides a wealth of experience for guiding research in the peptide binding interactions and target identification of cell surface receptors associated with neoplastic transformation in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Xiaoju (George) Wang, Ph.D is also a Co-Director for Core C: Peptides for this NTR Research Center. Dr. G Wang has significant experience in techniques of phage display, in particular with employing high-throughput phage epitope microarrays and multiplexed protein/epitope microarrays. These resources will be valuable for performing peptide screening to identify optimal candidates for subsequent clinical use, and will be available to all of the investigators in the network.

核心C：肽 - 肽核心的整体任务是提供所需的资源和服务选择，屏幕，序列，合成，标记和分析要在主要和任务中使用的肽特定的项目，用于胃肠道中的优先结合和检测发育异常。 Chung 医学博士Owyang是该拟议的NTR研究中心的Core C：肽的总监。 Owyang博士也是 P.I. NIH/NIDDK的密歇根大学胃肠病学肽研究核心中心资助的消化疾病中心的任务是研究功能性能和信号传导肠肽的机制。他提供了丰富的经验来指导肽约束的研究与肿瘤转化相关的细胞表面受体的相互作用和目标鉴定消化道。 Henriette Remmer博士是该核心的联合导演。她还是蛋白质的主任密歇根大学的结构核心设施，并在肽技术方面具有丰富的经验合成和蛋白质结构分析。 Remmer博士将以网络调查人员的身份作为有关肽的所有开发，合成和分析的所有步骤作为探针的咨询资源消化道中的恶性粘膜检测。 Henriette Remmer博士是此的联合主任核。她还是密歇根大学蛋白质结构核心设施的主任，并且在肽合成和蛋白质结构分析技术方面的重要经验。 Remmer博士将网络调查人员可作为有关开发步骤的咨询资源，合成和分析肽作为检测消化道上恶性粘膜的探针。 Xiaoju（George）Wang，博士学位也是该NTR研究中心的Core C：肽的联合导演。 G博士王在噬菌体显示技术方面具有丰富的经验，特别是使用高通量噬菌体表位微阵列和多路复用蛋白/表位微阵列。这些资源对于进行肽筛查以识别最佳候选者以供随后的临床使用，并将可用网络中的所有调查人员。