Institute for Clinical and Translational Science

临床与转化科学研究所

基本信息

批准号：
8284450
负责人：
DAN M COOPER
金额：
$ 18.98万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8284450
关键词：
Academic Medical Centers Award Basic Science Biological Markers Biophotonics California Childhood Clinical Clinical Data Clinical Research Clinical Sciences Collaborations Communities Community Healthcare Community Outreach Discipline Discipline of Nursing Doctor of Philosophy Education Educational Curriculum Elder Abuse Exercise Faculty Feedback Funding Generations Genomics Goals Health Health Personnel Health Sciences Healthcare Hospitals Human Information Sciences Institutes Instruction Interdisciplinary Study Investments Latino Link Master of Public Health Medical Medical Education Medical Students Mentored Clinical Scientist Development Program Mentors Mentorship Methodology Mitochondrial Diseases Molecular Nurses Obesity Participant Phase Physicians Process Program Development Public Health Research Research Infrastructure Research Personnel Research Proposals Research Training Resources Rewards Schools Science Scientist Students Sudden Death System Technology Testing Training Training Programs Translational Research Underinsured United States National Institutes of Health Universities Vision Work base biomedical informatics career career development clinical practice comparative effectiveness computer science design disease phenotype effectiveness research experience graduate student health care delivery innovation interoperability member new technology next generation novel novel strategies outreach pre-doctoral prevent programs skills social volunteer

项目摘要

Three years ago, UCI created the Institute for Clinical and Translational Science (ICTS), which identifies tests, and implements innovative ways to break down barriers that impede biomedical discovery. In the next phase of our concerted effort to transform the UCI clinical research enterprise, our vision is to: 1) Nurture Novel Collaborations-The ICTS builds multidisciplinary research teams, such as chemists and clinicians exploring breath biomarkers in the human "ventilome." ICTS experts in the science of team science will help new partnerships to identify and remove obstacles to successful collaboration before they become insurmountable. 2) Create New Technologies for Translational Science-^The ICTS made novel UCI-based technologies such as biophotonics and microdevices available to a new generation of clinicians. We will now develop and provide new methodologies by partnering with UCI information scientists in the use of ubiquitous computing for field research; with nursing and social scientists for qualitative and comparative effectiveness research; and with exercise physiologists and molecular biologists for technologies that link genomic information with dynamic disease phenotypes. 3) Share Information-The ICTS has engaged clinicians, hospital IT staff, and scholars from the School of Information and Computer Sciences to create the Center for Biomedical Informatics. We are now ready to embed infrastructure for clinical data interoperability at a unique moment, namely, as UCI begins to deploy its EMR; 4) Engage Our Community-The ICTS championed new approaches such as PEER (Participant Experience Enhancement in Research), a program that views research volunteers as partners in the process of discovery. We plan a range of outreach/dissemination activities, from mitigating elder abuse to preventing sudden death in pediatric athletes. And 5) Train-^We will implement Crossing BoLindaries, a set of degree and certificate programs along with mentorship interaction that tackles key issues in translational science. Finally, we view ourselves as part of a unique translational science network for Southern California, in which the resources of regional academic medical centers are integrated to better realize the overarching vision of the CTSA. RELEVANCE (See instructions): UCI is becoming a motivating force for clinical research in this dynamic region of Southern California. The ICTS will support a wide range of projects that will benefit public health, including the ambitious NIH-funded National Childen's Study; research into rare, poorly studied diseases of mitochondrial origin; and community outreach efforts to mitigate the health consequences of obesity among underinsured people in our region.

三年前，UCI创建了临床与转化科学研究所（ICT），该研究所确定测试，并实现创新的方法来打破阻碍生物医学发现的障碍。在下一个我们共同努力改变UCI临床研究企业的阶段，我们的愿景是：1）新颖的合作 - ICT建立了多学科研究团队，例如化学家和临床医生探索人类“通用物”中的呼吸生物标志物。 ICTS科学科学专家将有助于新的合作伙伴关系，以识别和消除成功合作的障碍不可逾越。 2）为转化科学创建新技术 - ICT制作了基于UCI的新技术新一代临床医生可用于生物探测器和微型版本之类的技术。我们现在会通过与UCI信息科学家合作开发和提供新的方法论用于现场研究的普遍计算；与护理和社会科学家进行定性和比较有效研究；以及锻炼生理学家和分子生物学家，用于连接的技术具有动态疾病表型的基因组信息。 3）共享信息 - ICT已参与信息与计算机科学学院的临床医生，医院IT员工和学者创建生物医学信息学中心。现在，我们准备嵌入基础架构以进行临床数据互操作性在一个独特的时刻，即UCI开始部署其EMR。 4）参与我们的社区ICT 倡导了等新方法，例如Peer（参与者的研究中的参与者体验），该计划这将研究志愿者视为发现过程中的合作伙伴。我们计划一系列宣传/传播活动，从减轻虐待老年人到预防小儿突然死亡运动员。 5）火车 - ^我们将实施交叉货币，一组学位和证书计划以及指导互动，解决转化科学中的关键问题。最后，我们看待自己作为南加州独特转化科学网络的一部分，该地区的资源学术医疗中心被整合在一起，以更好地实现CTSA的总体愿景。相关性（请参阅说明）：在南加州这个动态地区，UCI正在成为临床研究的激励力量。这 ICT将支持各种各样的项目，这些项目将使公共卫生受益，包括雄心勃勃的NIH资助国家儿童的研究；研究线粒体起源的罕见，研究不足的疾病；和社区宣传努力，以减轻我们地区保险人不足的人中肥胖的健康后果。