A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan

体力活动分子传感器儿科临床中心 (MoTrPAC)：绘制儿科全生命周期健康起源的运动分子图谱

• 批准号: 10265121
• 负责人: DAN M COOPER
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265121
• 关键词: Acute; Address; Adolescent; Adult; Aerobic; Aerobic Exercise; Affect; Asthma; Biological Markers; Blood; Blood Vessels; Body Composition; Body measure procedure; Cardiopulmonary; Caregivers; Child; Child Health; Childhood; Chronic; Chronic Disease; Communities; Complement; Computational Technique; Coupled; Data; Data Set; Discipline; Dose; Dual-Energy X-Ray Absorptiometry; Educational Intervention; Ensure; Epidemic; Epigenetic Process; Equilibrium; Exercise; Exercise Test; Family; Funding; Future; Gases; Gene Expression; Gene Expression Profile; Genetic; Genomics; Goals; Growth; Growth and Development function; Health; Health Benefit; Health Professional; Health Promotion; Heart Rate; Homeostasis; Human; Human Resources; Inflammation; Intervention; Journals; Knowledge; Laboratories; Leukocytes; Life; Link; Longevity; Maps; Measures; Mediating; Medicine; Methodology; Modernization; Molecular; Monitor; Multicenter Studies; New England; Obesity; Participant; Phenotype; Physical Fitness; Physical activity; Physiological; Play; Positioning Attribute; Process; Proteomics; Protocols documentation; Publishing; Regulatory Pathway; Reproducibility; Research; Research Technics; Role; Schools; Series; Specimen; Standardization; Supervision; System; Testing; Tissues; Training; Transducers; United States National Institutes of Health; Vision; Work; Youth; age related; base; boys; circulating biomarkers; clinical center; cost effective; critical period; design; disability; equipment training; exercise training; experience; girls; health training; innovation; insight; metabolomics; novel; novel strategies; physical conditioning; premature; prevent; programs; prospective; recruit; response; sex; square foot; transcriptomics; type 2 diabetes in children

A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan The goals of this research are to: 1) map the molecular mechanisms through which exercise benefits health in children and adolescents, a critical period of change in the human phenotype, and 2) provide the MoTrPAC consortium with rigorously collected and reproducible data from exercise studies in children and adolescents. This proposal is based on exciting discoveries in a range of disciplines, including: 1) new insights into age- dependent progression of gene expression during growth in children, 2) emerging data highlighting the central role played by leukocytes (n.b., an accessible tissue in child health research) in transducing exercise into health benefits, 3) pilot data showing remarkable interaction between the molecular transducers of growth and the molecular transducers of exercise, and 4) novel approaches to measuring and understanding physiologic and morphometric responses to acute and chronic exercise in children. In the proposed acute exercise studies, the immediate physiologic, proteomic, metabolomic, and leukocyte function and transcriptomic response to a brief exercise-induced perturbation in cellular homeostasis will be measured in a cross section of early- and late-pubertal boys and girls. In the proposed chronic exercise studies (a 12-week, prospective, aerobic exercise training intervention), we will compare the magnitude of the biomarker and molecular adaptation to training, along with the accompanying morphometric and physiologic changes between early- and late-pubertal girls and boys. The combined data from the acute and chronic exercise studies will be analyzed with systems- computational techniques to map the networks that transduce physical activity to health in the growing child and adolescent. Because phenotype is a “moving target” during growth, we will use accurate methodologies (such as DXA for body composition and breath-by-breath gas exchange for cardiopulmonary exercise testing) that have proven in our hands to be feasible in large numbers of children and adolescents. Traditional exercise testing will be complemented by laboratory-based “real-life” exercise protocols, and in all cases, scaled to each participant’s physical fitness, estimates of habitual physical activity, noninvasive measures of vascular health, and training volume and mode. In this way, the pediatric and adult data will be readily integrated. As an academic health center unit devoted uniquely to the study of physical activity and health in children in a very diverse region, our group is exceptionally qualified to contribute to the MoTrPAC consortium. We 1) published a series of discoveries of novel genomic and epigenetic exercise biomarkers in circulating leukocytes in both children and adults, 2) performed thousands of pediatric exercise tests, 3) conducted many successful prospective exercise training interventions in early and late pubertal children, and 4) were leaders in Project HEALTHY, the large NIH multicenter study to prevent obesity and type 2 diabetes in children, published in the New England Journal of Medicine. This research will ultimately enable child health professionals, families, and community leaders to optimize the use of exercise to promote health during a critical period of growth.

小儿体育活动分子换能器（MOTRPAC）的小儿临床中心：朝向A 整个生命周期的儿科起源中运动的分子图 这项研究的目标是：1）绘制运动使健康受益于健康的分子机制 儿童和青少年，人类表型的关键时期，2）提供Motrpac 从儿童和青少年的运动研究中，具有严格收集和可重复的数据的财团。 该建议基于一系列学科的令人兴奋的发现，包括：1）对年龄的新见解 - 儿童生长过程中基因表达的依赖性进展，2）强调中央的新兴数据 白细胞（N.B.，儿童健康研究中可访问的组织）扮演的角色 健康益处，3）试验数据显示生长的分子传感器与 运动的分子传感器和4）测量和理解生理的新方法 以及对儿童急性和慢性运动的形态反应。在拟议的急性运动研究中 直接生理，蛋白质组学，代谢组和白细胞功能以及对A的转录组反应 短暂运动引起的细胞稳态扰动将在早期和 晚期男孩和女孩。在拟议的慢性运动研究中（一项为期12周的前瞻性有氧运动 运动训练干预），我们将比较生物标志物的大小和分子适应 训练，以及早期和晚期的参与形态计量学和生理变化 女孩和男孩。急性和慢性运动研究的合并数据将通过系统分析 计算技术以绘制将身体活动转化为健康儿童健康的网络 和青春期。因为表型是增长过程中的“移动目标”，所以我们将使用准确的方法 （例如用于身体成分的DXA和心肺运动测试的呼吸呼吸器交换） 在我们手中证明，在大量儿童和青少年中是可行的。传统练习 测试将由基于实验室的“现实生活”练习方案完成，在所有情况下，都缩放到每个情况下 参与者的身体健康，习惯性体育锻炼的估计，血管健康的无创测量， 以及训练量和模式。这样，小儿和成人数据将很容易融合。作为 学术健康中心部门专门致力于研究儿童的体育锻炼和健康 多元化的地区，我们的小组非常有资格为Motrpac联盟做出贡献。我们1）出版 两者中循环白细胞中新型基因组和表观遗传运动生物标志物的一系列发现 儿童和成人，2）进行了数千次小儿运动测试，3）进行了许多成功 前期和晚期儿童的前瞻性运动训练干预措施，以及4）是项目的领导者 健康，一项大型NIH多中心研究，以防止儿童肥胖和2型糖尿病，发表在 新英格兰医学杂志。这项研究最终将使儿童卫生专业人员，家庭和 社区领导者在关键的成长期间优化使用运动来促进健康。