Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)

罗切斯特骨骼、肌肉和骨科研究资源中心 (ROCSTARR)（整体申请）

• 批准号: 10232833
• 负责人: Edward M. Schwarz
• 金额: $ 77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10232833
• 关键词: Academic Medical Centers; Address; Animal Model; Award; Basic Science; Biochemistry; Biocompatible Materials; Biology; Biomechanics; Biometry; Budgets; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Country; Department chair; Direct Costs; Effectiveness; Elements; Endowment; Ensure; Environment; Exercise; Faculty; Female; Fostering; Funding; Goals; Grant; Histology; Human Subject Research; Infrastructure; International; Investments; Leadership; Letters; Medicine; Mentors; Mission; Modeling; Muscle; Musculoskeletal; Orthopedics; Outcomes Research; Paper; Physicians; Publications; Reproducibility; Research; Research Assistant; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resource Sharing; Resources; Role; Running; Scientist; Seeds; Series; Services; Structure; Talents; Tissue imaging; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Work; academic program; base; big-data science; bone; clinical translation; collaborative environment; computer program; cost effective; high standard; human subject; improved; laboratory facility; male; meetings; member; molecular imaging; multimodality; next generation; novel; outreach; population health; professor; programs; ranpirnase; research facility; response; success; surgery outcome; symposium; tenure track; tool

This is a proposal to sustain the University of Rochester Resource-based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) Program. ROCSTARR is comprised of an Administrative Core that will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (B2MTI) Cores, in order to ensure progress of the overall ROCSTARR in an efficient manner. The Core Users Committees, the URMC Shared Resource Laboratories & Facilities, and the meeting structure of the Administrative Core are key elements that organize communication and collaboration among the ROCSTARR investigators, as well as with other faculty in the Center for Musculoskeletal Research (CMSR) and collaborating Departments and Centers within the University. The Specific Aims of the ROCSTARR are: 1) To maintain state-of-the-art resource- based Cores for basic science, translational and clinical musculoskeletal research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that serves as a model for translation of basic research to clinical trials, and expands our outreach activities that promote the use of the resources offered by the Core to new external collaborations with the aim of growing our musculoskeletal research base at URMC, nationally and internationally. 3) To: i) maintain our exceptional 42-fold return on investment from Pilot Grants awarded to New/Early Stage Investigators (N/ESI), ii) commence utilization of a new Discovery Fund created with small endowments for research in the prior funding period, and grow it via targeted philanthropy, and iii) sustain our renowned academic Enrichment Programs including the William F. Neuman Visiting Professor series and the Annual Musculoskeletal Research Symposium. 4) To maintain our Sub-Cores that administer: i) human subject research services in concert with the Clinical-Translational Research Institute, ii) biostatistics, computer programing and outcome research resources to grow collaborative networks in Big Data science, surgical outcomes and population health research, and iii) provide new resources for muscle and exercise biology research in animal models and human subjects. And, 5) to expand our highly successful Mentoring Program, which facilitates the advancement of our N/ESIs to NIH R01 funded PIs with national leadership status, and implements the highest standards of scientific rigor in response to NIH’s plan to enhance reproducibility. Thus, building on our remarkable successes during the prior funding period, this P30 Core Center proposes to continue its mission “To advance our faculty members to independence, establishing them as national leaders and the most desirable faculty in their field by the top academic programs in the country, upon which the ultimate success of this Core Program will be judged.”

这是维持罗切斯特大学骨，肌肉和骨骼资源中心的一项建议 骨科研究（ROCSTARR）计划。 RocStarr已完成一个行政核心，该核心将 运行富集程序，并将协调和整合组织学，生物化学和分子 成像（HBMI）以及生物力学，生物材料和多模式组织成像（B2MTI）核心，以便为了 确保以有效的方式确保整体RocStarr的进展。核心用户委员会，URMC 共享资源实验室和设施以及行政核心的会议结构是关键 Rocstarr调查人员之间组织沟通和协作的要素以及 肌肉骨骼研究中心（CMSR）和合作部门和中心的其他教师 在大学内。 Rocstarr的具体目的是：1）维持最新的资源 - 基于基础科学，翻译和临床肌肉骨骼研究的核心；并利用这些资源 以具有成本效益的方式加速发现和临床翻译的速度。 2）继续养育 我们高度协作的环境是将基础研究转换为临床试验的模型， 并扩大我们的外展活动，以促进核心提供的资源的使用 合作的目的是在URMC，全国和 国际。 3）至：i）维持我们从授予的飞行员赠款的42倍投资回报率 新/早期研究人员（N/ESI），ii）开始利用一个新的发现基金 在以前的资助期内进行研究的捐赠，并通过有针对性的慈善事业发展，iii）维持我们的 著名的学术丰富计划，包括威廉·诺伊曼（William F. Neuman）访问教授系列和 年度肌肉骨骼研究研讨会。 4）维护管理的子核：i）人类 主题研究服务与临床翻译研究所共同，ii）生物统计学，计算机 编程和结果研究资源，以发展大数据科学中的协作网络 成果和人口健康研究以及iii）为肌肉和运动生物学提供新的资源 动物模型和人类受试者的研究。 5）为了扩大我们非常成功的指导计划， 这促进了我们的N/ESI到NIH R01的进步，为具有国家领导地位的PI提供了资金， 根据NIH提高可重复性的计划，实现了科学严谨的最高标准。那， 在以前的资助期间，这项P30核心中心提议以我们的杰出成功为基础 继续其使命“促进我们的教职员工到独立，将他们确立为国家领导人 以及该国顶级学术课程中最理想的教师 该核心计划的最终成功将被判断。”