Administrative Core

行政核心

• 批准号: 10247793
• 负责人: Edward M. Schwarz
• 金额: $ 38.33万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247793
• 关键词: 3D Print; Address; Advisory Committees; Algorithms; Antibiotics; Antibodies; Award; Biochemistry; Biocompatible Materials; Biological Assay; Biology; Biomechanics; Biometry; Caring; Cessation of life; Clinical; Clinical Research; Communicable Diseases; Communication; Communities; Custom; Development; Diagnosis; Evaluation; Event; Evolution; Fostering; Funding; Genetic; Genus staphylococcus; Goals; Health Services Research; Histology; Human Resources; Humoral Immunities; Immune; Immunity; Immunology; Infection; Intervention; Joint Prosthesis; Lead; Measures; Mediating; Medicine; Molecular; Multiple Organ Failure; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Osteomyelitis; Pathogenesis; Pathology; Patient risk; Patients; Pilot Projects; Predisposition; Prevention; Primary Infection; Proteome; Quality Control; Replacement Arthroplasty; Research; Research Personnel; Resistance; Resources; Running; Schedule; Signal Pathway; Staphylococcus aureus; Staphylococcus aureus infection; Structure; Surgeon; Surgical Wound Infection; System; Tissue Engineering; Tissue imaging; Translating; Translational Research; United States National Institutes of Health; Universities; base; bone; cortical bone; cost effective; drug discovery; improved; indexing; infection rate; joint infection; materials science; meetings; methicillin resistant Staphylococcus aureus; microbial; molecular imaging; multidisciplinary; multimodality; novel; osteoimmunology; programs; ranpirnase; septic; trauma care

Abstract The Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI) is the evolution of two highly successful programs (AOTrauma Clinical Priority Program on Bone Infection (AO-CPP); and NIAMS P50 CORT AR54041 “Translating Molecular Signal Pathways to Orthopaedic Trauma Care”), which are run by multidisciplinary teams of investigators in the University of Rochester Center for Musculoskeletal Research. To capitalize on the salient strengths of these programs, the CoRTOBI now proposes to advance the basic and translational scientific and technological discoveries from the AO-CPP on S. aureus infection of bone and host immunity, using the proven administrative structure of the P50 CORT. In so doing, the proposed CoRTOBI Administrative Core will bring together renowned experts in microbial pathogenesis & genetics, antibiotic drug discovery, material science, tissue engineering, immunology, bone pathology, biostatistics and orthopaedic surgery, who are dedicated to the goals of improved prevention, diagnosis, and treatments for osteomyelitis patients. The Administrative Core will provide operational and fiscal management of the CoRTOBI. It will also support the clinical research and biostatistical needs of the Projects and Research Core, facilitate communications, run the enrichment programs, and implement a Pilot and Feasibility Project Program. Dr. Edward Schwarz will serve as the Director. He will be assisted by Dr. Hani Award (Associate Director), Dr. Stephen Kates (Director of the Clinical Research Sub-Core), and Dr. Christopher Beck (Director of the Biostatistics Sub-Core). These Directors will be advised by a Steering Committee, an Internal Advisory Committee (IAB), and an External Advisory Committee (EAB). The Specific Aims of the Administrative Core are to: Aim 1. Govern the entire CoRTOBI, which includes administration of personnel, financial oversight, and quality controls on services and research progress through evaluations at scheduled meetings. Aim 2. Foster communications between CoRTOBI Project & Core investigators, the IAC & EAC, our NIH funded CTSAs, NIH/NIAMS Program staff, and the greater scientific community. Aim 3. Coordinate cost-effective access to the HBMI and BBMTI Cores supported by The University of Rochester Resource-Based Center for Musculoskeletal Biology & Medicine; NIAMS P30 AR069655. Aim 4. Establish a Pilot and Feasibility Project Program (PFPP) in Bone Infection that will synergize with our CTSAs and NIAMS P30 Pilot Project Programs. Aim 5. Provide enrichment opportunities for CoRTOBI investigators, bone infection researchers, orthopaedic surgeons, and the larger scientific and lay communities.

抽象的 骨感染骨免疫学研究翻译中心 (CoRTOBI) 两个非常成功的项目的演变（AOTruma 骨感染临床优先项目 (AO-CPP)；和 NIAMS P50 CORT AR54041“将分子信号通路转化为骨科 创伤护理”），由罗切斯特大学的多学科研究团队负责管理 为了利用这些项目的显着优势，肌肉骨骼研究中心。 CoRTOBI 现在提议推进基础性和转化性科学技术发现 AO-CPP 对骨金黄色葡萄球菌感染和宿主免疫的影响，使用经过验证的管理方法 P50 CORT 的结构 这样一来，拟议的 CorTOBI 管理核心将汇集在一起​​。 微生物发病机制和遗传学、抗生素药物发现、材料科学、 组织工程、免疫学、骨病理学、生物统计学和骨科手术， 致力于改善骨髓炎患者的预防、诊断和治疗目标。 行政核心将为 CoRTOBI 提供运营和财务管理。 支持项目和研究核心的临床研究和生物统计需求，促进 沟通、运行丰富项目并实施试点和可行性项目计划。 爱德华·施瓦茨 (Edward Schwarz) 博士将担任主任，他将得到哈尼奖 (Hani Award) 副教授的协助。 主任）、Stephen Kates 博士（临床研究子核心主任）和 Christopher Beck 博士 （生物统计子核心主任）这些主任将接受指导委员会的建议。 内部咨询委员会 (IAB) 和外部咨询委员会 (EAB)。 行政核心的具体目标是： 目标 1. 治理整个 CoRTOBI，包括人事管理、财务监督、 通过定期会议的评估对服务和研究进展进行质量控制。 目标 2. 促进 CoRTOBI 项目和核心研究人员、IAC 和 EAC、我们的 NIH 资助 CTSA、NIH/NIAMS 项目工作人员以及更大的科学界。 目标 3. 协调以具有成本效益的方式访问由英国大学支持的 HBMI 和 BBMTI 核心 罗彻斯特肌肉骨骼生物学与医学资源中心；NIAMS P30 AR069655。 目标 4. 建立骨感染试点和可行性项目计划 (PFP​​P)，以发挥协同作用 与我们的 CTSA 和 NIAMS P30 试点项目计划一起。 目标 5. 为 CoRTOBI 研究人员、骨感染研究人员、 骨科医生以及更大的科学界和非专业界。