Administrative Core

行政核心

• 批准号: 10247793
• 负责人: Edward M. Schwarz
• 金额: $ 38.33万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247793
• 关键词: 3D Print; Address; Advisory Committees; Algorithms; Antibiotics; Antibodies; Award; Biochemistry; Biocompatible Materials; Biological Assay; Biology; Biomechanics; Biometry; Caring; Cessation of life; Clinical; Clinical Research; Communicable Diseases; Communication; Communities; Custom; Development; Diagnosis; Evaluation; Event; Evolution; Fostering; Funding; Genetic; Genus staphylococcus; Goals; Health Services Research; Histology; Human Resources; Humoral Immunities; Immune; Immunity; Immunology; Infection; Intervention; Joint Prosthesis; Lead; Measures; Mediating; Medicine; Molecular; Multiple Organ Failure; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Osteomyelitis; Pathogenesis; Pathology; Patient risk; Patients; Pilot Projects; Predisposition; Prevention; Primary Infection; Proteome; Quality Control; Replacement Arthroplasty; Research; Research Personnel; Resistance; Resources; Running; Schedule; Signal Pathway; Staphylococcus aureus; Staphylococcus aureus infection; Structure; Surgeon; Surgical Wound Infection; System; Tissue Engineering; Tissue imaging; Translating; Translational Research; United States National Institutes of Health; Universities; base; bone; cortical bone; cost effective; drug discovery; improved; indexing; infection rate; joint infection; materials science; meetings; methicillin resistant Staphylococcus aureus; microbial; molecular imaging; multidisciplinary; multimodality; novel; osteoimmunology; programs; ranpirnase; septic; trauma care

Abstract The Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI) is the evolution of two highly successful programs (AOTrauma Clinical Priority Program on Bone Infection (AO-CPP); and NIAMS P50 CORT AR54041 “Translating Molecular Signal Pathways to Orthopaedic Trauma Care”), which are run by multidisciplinary teams of investigators in the University of Rochester Center for Musculoskeletal Research. To capitalize on the salient strengths of these programs, the CoRTOBI now proposes to advance the basic and translational scientific and technological discoveries from the AO-CPP on S. aureus infection of bone and host immunity, using the proven administrative structure of the P50 CORT. In so doing, the proposed CoRTOBI Administrative Core will bring together renowned experts in microbial pathogenesis & genetics, antibiotic drug discovery, material science, tissue engineering, immunology, bone pathology, biostatistics and orthopaedic surgery, who are dedicated to the goals of improved prevention, diagnosis, and treatments for osteomyelitis patients. The Administrative Core will provide operational and fiscal management of the CoRTOBI. It will also support the clinical research and biostatistical needs of the Projects and Research Core, facilitate communications, run the enrichment programs, and implement a Pilot and Feasibility Project Program. Dr. Edward Schwarz will serve as the Director. He will be assisted by Dr. Hani Award (Associate Director), Dr. Stephen Kates (Director of the Clinical Research Sub-Core), and Dr. Christopher Beck (Director of the Biostatistics Sub-Core). These Directors will be advised by a Steering Committee, an Internal Advisory Committee (IAB), and an External Advisory Committee (EAB). The Specific Aims of the Administrative Core are to: Aim 1. Govern the entire CoRTOBI, which includes administration of personnel, financial oversight, and quality controls on services and research progress through evaluations at scheduled meetings. Aim 2. Foster communications between CoRTOBI Project & Core investigators, the IAC & EAC, our NIH funded CTSAs, NIH/NIAMS Program staff, and the greater scientific community. Aim 3. Coordinate cost-effective access to the HBMI and BBMTI Cores supported by The University of Rochester Resource-Based Center for Musculoskeletal Biology & Medicine; NIAMS P30 AR069655. Aim 4. Establish a Pilot and Feasibility Project Program (PFPP) in Bone Infection that will synergize with our CTSAs and NIAMS P30 Pilot Project Programs. Aim 5. Provide enrichment opportunities for CoRTOBI investigators, bone infection researchers, orthopaedic surgeons, and the larger scientific and lay communities.

抽象的 关于骨骼感染（Cortobi）骨气免疫学（Cortobi）的研究翻译中心 两个非常成功的程序的演变（Aotrauma临床优先级有关骨骼感染的优先计划 （AO-CPP）; Niams P50 Cort AR54041“将分子信号途径转换为骨科 创伤护理”，由罗切斯特大学的多学科研究人员组成 肌肉骨骼研究中心。为了利用这些计划的显着优势， Cortobi现在提出提出的基本和翻译的科学和技术发现 使用经过验证的行政管理 P50 Cort的结构。这样做，拟议的Cortobi行政核心将聚集在一起 著名的微生物发病机理和遗传学，抗生素药物发现，材料科学， 组织工程，免疫学，骨病理学，生物统计和骨科手术， 致力于改善骨髓炎患者预防，诊断和治疗方法的目标。 行政核心将提供Cortobi的运营和财政管理。它也会 支持项目和研究核心的临床研究和生物统计需求，准备 沟通，运行丰富程序，并实施飞行员和可行性项目计划。 爱德华·施瓦茨（Edward Schwarz）博士将担任董事。他将获得Hani博士奖（助理）的协助 导演），斯蒂芬·凯特（Stephen Kates）博士（临床研究子核心的主任）和克里斯托弗·贝克（Christopher Beck）博士 （生物统计学子核心主任）。这些董事将由指导委员会建议 内部咨询委员会（IAB）和外部咨询委员会（EAB）。 行政核心的具体目的是： AIM 1。管理整个Cortobi，其中包括人员管理，财务监督， 以及通过预定会议评估的服务和研究进展的质量控制。 AIM 2。Cortobi Project与核心调查员，IAC＆EAC之间的寄养通讯 NIH资助了CTSA，NIH/NIAMS计划人员和更大的科学界。 目标3。协调对大学支持的HBMI和BBMTI核心的成本效益访问 基于罗切斯特的肌肉骨骼生物学与医学中心； Niams P30 AR069655。 目标4。在骨骼感染中建立一个飞行员和可行性项目计划（PFPP），该计划将协同作用 通过我们的CTSA和NIAMS P30试点项目计划。 AIM 5。为Cortobi研究人员，骨骼感染研究人员提供丰富机会， 骨科医生以及更大的科学和外行社区。