Neurocognitive Training to Improve Executive Function

神经认知训练以改善执行功能

基本信息

批准号：
8251507
负责人：
Timothy H. Riehle
金额：
$ 18.07万
依托单位：
KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8251507
关键词：
Achievement Adolescent Age Area Attention Attention deficit hyperactivity disorder Autistic Disorder Behavior Biofeedback Biomedical Technology Brain Characteristics Child Childhood Clinical Clinical Research Cognition Cognitive Collaborations Computers Conduct Disorder Custom Data Decision Making Development Devices Disease Economics Electroencephalography Electronics Equipment Eye Feedback Frequencies Generations Glass Goals High Prevalence Impairment Imprisonment Individual Informal Social Control Learning Lens Opacities Letters Marketing Mathematics Measures Mental disorders Minnesota Neurocognitive Nursery Schools Parents Pattern Peer Review Performance Phase Physiological Play Prefrontal Cortex Primary Schools Problem Solving Process Production Reading Regimen Relative (related person)Research Role Scalp structure Schools Secondary Schools Self-control as a personality trait Short-Term Memory Small Business Technology Transfer Research Sorting - Cell Movement Substance abuse problem System Technology Television Testing Time Training United States National Institutes of Health Universities Video Games Work base commercialization cost design design and construction executive function flexibility functional improvement high risk human study improved indexing innovation lens mental state neurofeedback novel programs prototype resilience retinal rods selective attention skills social success teacher tool transmission process usability

Achievement Adolescent Age Area Attention Attention deficit hyperactivity disorder Autistic Disorder Behavior Biofeedback Biomedical Technology Brain Characteristics Child Childhood Clinical Clinical Research Cognition Cognitive Collaborations Computers Conduct Disorder Custom Data Decision Making Development Devices Disease Economics Electroencephalography Electronics Equipment Eye Feedback Frequencies Generations Glass Goals High Prevalence Impairment Imprisonment Individual Informal Social Control Learning Lens Opacities Letters Marketing Mathematics Measures Mental disorders Minnesota Neurocognitive Nursery Schools Parents Pattern Peer Review Performance Phase Physiological Play Prefrontal Cortex Primary Schools Problem Solving Process Production Reading Regimen Relative (related person)Research Role Scalp structure Schools Secondary Schools Self-control as a personality trait Short-Term Memory Small Business Technology Transfer Research Sorting - Cell Movement Substance abuse problem System Technology Television Testing Time Training United States National Institutes of Health Universities Video Games Work base commercialization cost design design and construction executive function flexibility functional improvement high risk human study improved indexing innovation lens mental state neurofeedback novel programs prototype resilience retinal rods selective attention skills social success teacher tool transmission process usability

展开

项目摘要

DESCRIPTION (provided by applicant): In this Phase I STTR project Koronis Biomedical Technologies (KBT) in close collaboration with the Zelazo Lab at the University of Minnesota proposes to develop an electroencephalography (EEG) based neurocognitive training tool to enable individuals to improve neurocognitive processes associated with executive function (EF). Processes involved in self-control and goal-directed problem solving referred to as Executive Function play an instrumental role in learning and comprise a key protective system for academic resilience in high-risk children. Shortcomings in Executive Function have a higher prevalence in low social economic status children and are correlated to higher rates of incarceration, substance abuse, and lower academic performance. Neurocognitive training is a form of biofeedback in which real-time measures of brainwave activity are presented to the individual to enable them to willfully control their current mental state. Gamma states (EEG activity above 30Hz) in addition to Beta wavelengths will be detected on the frontal scalp and used to drive custom hardware to provide instantaneous feedback through an innovative mode of action. It is hypothesized that high frequency activity in the prefrontal area is associated with processes implicated in executive function. Advantages of the proposed product when compared to existing commercial EEG-based feedback devices on the market are the following: Executive Function (EF) is the target which has not been the case previously; feedback mode of action is independent of video games and video consoles; device can be used during reading, listening and real-world activities that should greatly improve generalizability and sustainability of improvements to real-world skills and behaviors; improvements in EF will be confirmed with standardized assessments from NIH toolbox and other validated peer-reviewed measures as opposed to subjective parent/teacher ratings. The feasibility of the system will be evaluated in this Phase I project by pursuing four specific aims: 1) Construct a prototype EEG neurocognitive training system for Executive Function improvement; 2) Develop a neurocognitive training regimen consisting of a program of diverse and engaging activities for children and young adolescents; 3) Conduct a pilot human study to assess whether it is possible to increase relative gamma power and other wavelengths over the frontal scalp using EEG neurocognitive training; and 4) use the NIH Toolbox Cognition measures to assess whether improvements are seen in behavior (esp. EF), and whether they are correlated with increases in gamma power or other wavelength patterns. The results from this Phase I project will be used to design a portable prototype to evaluate in clinical studies and to validate and verify requirements of a refined product design for the clinical, school and learning center markets to improve executive function in children. PUBLIC HEALTH RELEVANCE: Neurocognitive processes involved in self-control and goal-directed problem solving referred to as executive function play an instrumental role in learning and comprise a key protective system for resilience in high-risk children. Neurofeedback based on electroencephalography signatures correlated with these neurocognitive processes may provide powerful tools to aid in the development of these cognitive processes and the managing of healthy behaviors. Shortcomings in executive function are characteristic of children with a variety of disorders (e.g., ADHD, Conduct Disorder, autism) and are correlated with higher rates of incarceration, substance abuse, and lower academic performance.

描述（由申请人提供）：在此I阶段，与明尼苏达大学的Zelazo Lab密切合作，在此I阶段，Minnesota University的Zelazo Lab提议开发基于脑电图（EEG）的神经认知训练工具，以使个人能够改善与执行功能相关的神经认知过程（EF）。所谓的执行功能的自我控制和目标解决问题的过程在学习中起着重要的作用，并构成了高风险儿童学术弹性的关键保护系统。执行职能的缺点在低社会经济地位儿童中的患病率更高，并且与更高的监禁，药物滥用和较低的学习成绩相关。神经认知训练是一种生物反馈的一种形式，其中将脑电波活动的实时度量提交给个人，使他们能够故意控制其当前的精神状态。除β波长外，还将在额叶头皮上检测到伽马状态（EEG活动30Hz以上），并用于驱动自定义硬件，以通过创新的动作方式提供瞬时反馈。假设前额叶区域的高频活动与涉及执行功能的过程有关。与现有的市场上基于商业脑电图的反馈设备相比，拟议产品的优势如下：执行功能（EF）是以前并非如此的目标；反馈方式独立于视频游戏和视频控制台；可以在阅读，倾听和现实世界中使用设备，这些设备应大大提高对现实世界技能和行为的改善的普遍性和可持续性；通过NIH工具箱的标准评估和其他经过验证的同行评审措施，与主观父母/老师评级相比，将确认EF的改进。该系统的可行性将在I阶段项目中评估四个特定目标：1）构建一个原型EEG神经认知训练系统，以改善执行功能； 2）开发一种神经认知培训方案，该方案包括针对儿童和年轻青少年的各种活动和参与活动的计划； 3）进行一项试验人类研究，以评估是否有可能使用脑电图神经认知训练在额头皮上增加相对伽马功率和其他波长； 4）使用NIH工具箱的认知度量来评估行为中是否看到改进（尤其是EF），以及它们是否与伽马功率的增加或其他波长模式相关。该阶段I项目的结果将用于设计便携式原型，以评估临床研究，并验证和验证对临床，学校和学习中心市场的精制产品设计的要求，以改善儿童的执行功能。公共卫生相关性：自我控制和目标的问题解决的神经认知过程，称为执行功能，在学习中起着工具作用，并构成了高风险儿童弹性的关键保护系统。基于与这些神经认知过程相关的脑电图特征的神经反馈可能会提供强大的工具来帮助发展这些认知过程和健康行为的管理。执行功能的缺点是患有多种疾病（例如ADHD，行为障碍，自闭症）的儿童的特征，并且与更高的监禁，滥用药物和较低的学习成绩相关。