Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

用于流动啮齿动物测量左心室压力和容量的无线系统

基本信息

批准号：
10002118
负责人：
Timothy H. Riehle
金额：
$ 70.76万
依托单位：
KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10002118
关键词：
Adverse drug effect Algorithms Anesthesia procedures Animal Testing Animals Biomedical Technology Blood Blood Volume Cardiac Cardiovascular system Catheters Chest Chronic Complex Computer software Conscious Data Data Analyses Development Devices Frequencies Goals Health Sciences Heart Heart Diseases Implant Left Left ventricular structure Market Research Measurement Measures Medical Medical Research Medicine Methods Modeling Monitor Mus Muscle Myocardial Myocardial Infarction Myocardium Pathway interactions Patients Pharmaceutical Preparations Pharmacologic Substance Phase Physiologic intraventricular pressure Principal Investigator Property Rattus Real-Time Systems Research Research Personnel Research Support Rodent Rodent Model Rofecoxib Scientist Sedation procedure Signal Transduction Small Business Innovation Research Grant Stroke Volume System Systems Analysis Techniques Technology Telemetry Texas Time Transgenic Model Two-Dimensional Echocardiography Universities Ventricular Function Wireless Technology base commercialization data acquisition data quality design drug efficacy electric impedance experience heart function heart pharmacology hemodynamics implantable device improved light weight medication safety miniaturize monitoring device novel novel therapeutics pressure product development professor prototype research clinical testing screening skills

项目摘要

Abstract In this Phase II SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the development of novel compounds and medications by large pharmaceutical companies. As a result, it has become increasingly important to accurately and thoroughly evaluate cardiac function in the mouse and rat model. Although implanted telemetric pressure systems have been successfully commercialized for both mice and rats, a device that also measures real-time volume in a free-roaming rodent has been absent to date. The proposed miniature, lightweight, fully implanted device will collect pressure and volume measurements using an admittance measurement technique and wirelessly transmit the measured data to a nearby base station.

抽象的在此II阶段SBIR中，Koronis生物医学技术建议开发和评估完全植入的在啮齿动物研究中监视剩下心室压力和体积（P-V）的无线设备。转基因模型通过对啮齿动物的假设驱动的研究创造了心脏病学术研究中的机械途径，并支持新型化合物的发展和大型制药公司的药物。结果，它变得越来越重要准确，彻底评估小鼠和大鼠模型中的心脏功能。虽然植入遥测压力系统已经成功地为小鼠和大鼠商业化，该设备也可以测量迄今为止，自由漫游啮齿动物中的实时体积尚无。拟议的微型，轻巧，完全植入设备将使用入学测量技术收集压力和体积测量并将测量数据无线传输到附近的基站。