Ultra-Miniature Dosimeter with Magnetic Localization

具有磁定位功能的超小型剂量计

• 批准号: 7998689
• 负责人: Timothy H. Riehle
• 金额: $ 12.9万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7998689
• 关键词: Accounting; Atlases; Autacoids; Biomedical Technology; Brain; Cancer Center; Complex; Computers; Consult; Coupled; Detection; Devices; Dose; Dose Fractionation; Electronics; Environment; External Beam Radiation Therapy; Film; Freedom; Goals; Head; Image; Implant; Intensity-Modulated Radiotherapy; Ionizing radiation; Laboratories; Lead; Lesion; Location; Magnetism; Measurement; Medical; Medical Oncologist; Motion; Movement; Nanotechnology; Normal tissue morphology; Organ; Patients; Phase; Positioning Attribute; Procedures; Property; Radiation; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radio; Radiobiology; Radiosurgery; Research Personnel; Resolution; Respiration; Rotation; Safety; Shapes; Signal Transduction; Simulate; Site; Specificity; System; Techniques; Technology; Three-Dimensional Imaging; Time; Tissues; Toxic effect; Update; Visit; Wireless Technology; Work; X-Ray Computed Tomography; base; cancer cell; cancer therapy; cost; design; dosimetry; experience; improved; in vivo; magnetic field; millimeter; new technology; next generation; programs; public health relevance; response; sensor; simulation; solid state; success; targeted delivery; transmission process; treatment planning; tumor

DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a wireless implantable dosimeter with the ability to track both location and orientation in real-time by combining radiation sensitive field- effect-device (RADFET) technology together with ultra-miniature magnetic field sensors based on giant magnetoresistance (GMR) technology. These devices will be combined into an implantable package together with power and wireless radio circuitry and antenna. The combination of real-time tumor tracking coupled with accurate dosimetry at the tumor site will enable radiation oncology teams to increase targeting accuracy and enhance dose delivery precision. Fast real-time targeting can offer reduced procedure setup time, increased work flow and provide real-time tumor location and orientation thereby reducing targeting inaccuracy due to inter- and intrafractional motion. The proposed program uses solid-state thin-film GMR sensors to reduce the size, increase the sensitivity and decrease the cost of the magnetic targeting system. Solid-state FET dosimeter technology provides similar benefits: excellent sensitivity, small size and inexpensive manufacturing costs. PUBLIC HEALTH RELEVANCE: Koronis Biomedical Technologies proposes an implantable dosimeter system with location sensing capability using a solid-state field-effect-device (FET) dosimeter together with thin-film giant magnetoresistive (GMR) sensors. These technologies will enable the real-time tracking of both position and orientation enabling of tumors via non-ionizing magnetic fields.

描述（由申请人提供）：Koronis生物医学技术（KBT）提议开发一种无线植入剂量剂量表，具有通过将辐射敏感的现场效应 - 设备（RADFET）技术与超级磁场传感器与基于巨型磁场（GMR）技术相结合的辐射敏感磁场效应（RADFET）技术，可以实时跟踪位置和方向。这些设备将与功率和无线无线电电路和天线结合在一起。实时肿瘤跟踪以及在肿瘤部位的准确剂量测定的结合将使辐射肿瘤学团队能够提高靶向准确性并提高剂量递送精度。快速实时目标可以提供减少的程序设置，增加工作流程并提供实时肿瘤位置，从而减少由于界面间运动和界面性运动而导致的靶向不准确性。提出的程序使用固态薄膜GMR传感器来降低尺寸，提高灵敏度并降低磁目标系统的成本。固态FET剂量计技术提供了类似的好处：出色的灵敏度，尺寸小和廉价的制造成本。 公共卫生相关性：Koronis生物医学技术提出了一种可植入的剂量计系统，该系统具有固态野外效应 - 设备（FET）剂量计以及薄膜巨型磁磁盘（GMR）传感器的位置传感能力。这些技术将通过非电离磁场实现位置和方向实现肿瘤的实时跟踪。