Peridontal Infection and systemic inflammation in renal patients

肾脏病患者的牙周感染和全身炎症

• 批准号: 8300011
• 负责人: Efthimia Ioannidou
• 金额: $ 14.04万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300011
• 关键词: Affect; Area; Attenuated; Award; Basic Science; Blood Circulation; C-reactive protein; Cardiovascular Diseases; Cessation of life; Chronic; Chronic Kidney Failure; Clinical; Clinical Research; Clinical Sciences; Commit; Connective Tissue; Dentistry; Development Plans; Disease; Disease Outcome; Drops; Ensure; Funding; Gingiva; Heart Diseases; High Prevalence; Immune system; Immunosuppression; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Instruction; Interleukin-6; Kidney; Kidney Failure; Laboratories; Lead; Mentors; Natural Immunity; Nephrology; Patients; Periodontal Diseases; Periodontal Infection; Periodontitis; Population; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Serum; Services; Systemic infection; Techniques; Tooth Loss; Training; Training Programs; United States National Institutes of Health; Uremia; Work; adaptive immunity; adverse outcome; base; career; career development; experience; high risk; improved; inflammatory marker; mortality; oral infection; patient oriented; patient oriented research; patient population; premature; programs

Candidate: The candidate is committed to a career in academic dentistry with a focus on patient-oriented research. This award will enable the candidate to achieve her career objectives, which are to gain additional experience and training in patient-oriented research and become an independent funded investigator in patient-oriented clinical research. Mentors: The primary mentor will be Dr. Anna Dongari-Bagtzoglou, who has extensive expertise in oral infection and inflammation. This combination of clinical and basic science expertise will ensure the comprehensive training program. Enviroment: A well-established research program in the proposed research area is in place. An NIH-funded GCRC provides supportive services for clinical research. Strong evidence of institutional commitment to the candidate's career development is also documented in the application. Career Development Plan: The didactic component will include course-work in areas relevant to patient-oriented research and nephrology. The clinical component will include experience in patient-oriented research projects. The laboratory component will include hands-on experience in inflammation laboratory techniques. Research Plan: We hypothesize that periodontal infections are highly prevalent in the CKD population and may affect the systemic inflammatory status of CKD patients. Moreover, we hypothesize that following periodontal treatment, the systemic inflammatory status of CKD patients will improve confirming the direct contribution of chronic periodontitis to the systemic inflammatory of CKD subjects. Specific Aim 1: a) to compare the prevalence of periodontal infection between CKD patients and non-CKD population and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients. Specific Aim 2: a) to assess the levels of the systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD populations, and b): to compare the serum EL-6 and CRP levels at baseline and 2 months after periodontal treatment. RELEVANCE (See instructions): The study will compare the prevalence of gum disease between renal and non-renal populations. Given the fact that the higher the levels of inflammatory markers in the circulation, the higher the risk for heart disease, the study will assess the effect of gum infection on the overall inflammatory status of renal subjects. Also, the study will assess the effect of gum treatment on the systemic inflammatory status of renal patients..

候选人： 候选人致力于学术牙科事业，重点关注以患者为中心的研究。这 该奖项将使候选人能够实现她的职业目标，即获得额外的经验和培训 以患者为导向的研究，并成为以患者为导向的临床研究的独立资助研究者。 导师：主要导师是 Anna Dongari-Bagtzoglou 博士，她在口腔感染和 炎。临床和基础科学专业知识的结合将确保全面的培训计划。 环境：在拟议的研究领域已经制定了完善的研究计划。 NIH 资助的 GCRC 为临床研究提供支持服务。机构对候选人职业生涯的承诺的有力证据 开发也记录在应用程序中。 职业发展计划：教学部分将包括与以患者为中心相关领域的课程作业 研究和肾脏病学。临床部分将包括以患者为导向的研究项目的经验。这 实验室部分将包括炎症实验室技术的实践经验。 研究计划：我们假设牙周感染在 CKD 人群中非常普遍，并可能影响 CKD 患者的全身炎症状态。此外，我们假设牙周治疗后， CKD 患者的全身炎症状态将得到改善，证实慢性牙周炎的直接影响 CKD 受试者的全身炎症。具体目标 1：a) 比较牙周感染的患病率 b) 探讨 CKD 患者与非 CKD 人群之间的关系 CKD 患者的感染和尿毒症状态。具体目标 2：a) 评估全身炎症水平 b)：比较 CKD 人群中存在或不存在牙周感染的情况下的标记物、IL-6 和 CRP 基线和牙周治疗后 2 个月的血清 EL-6 和 CRP 水平。 相关性（参见说明）： 该研究将比较肾病人群和非肾病人群的牙龈疾病患病率。鉴于 事实上，循环中炎症标志物的水平越高，患心脏病的风险就越高， 该研究将评估牙龈感染对肾脏受试者整体炎症状态的影响。另外， 研究将评估牙龈治疗对肾脏患者全身炎症状态的影响。