Peridontal Infection and systemic inflammation in renal patients

肾脏病患者的牙周感染和全身炎症

• 批准号: 8115842
• 负责人: Efthimia Ioannidou
• 金额: $ 14.04万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115842
• 关键词: Affect; Area; Attenuated; Award; Basic Science; Blood Circulation; C-reactive protein; Cardiovascular Diseases; Cessation of life; Chronic; Chronic Kidney Failure; Clinical; Clinical Research; Clinical Sciences; Commit; Connective Tissue; Dentistry; Development Plans; Disease; Disease Outcome; Drops; Ensure; Environment; Funding; Gingiva; Heart Diseases; High Prevalence; Immune system; Immunosuppression; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Interleukin-6; Kidney; Kidney Failure; Laboratories; Lead; Mentors; Natural Immunity; Nephrology; Patients; Periodontal Diseases; Periodontal Infection; Periodontitis; Population; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Serum; Services; Systemic infection; Techniques; Tooth Loss; Training; Training Programs; United States National Institutes of Health; Uremia; Work; adaptive immunity; adverse outcome; base; career; career development; experience; high risk; improved; inflammatory marker; mortality; oral infection; patient oriented; patient oriented research; patient population; premature; programs; public health relevance

DESCRIPTION (provided by applicant): Candidate: The candidate is committed to a career in academic dentistry with a focus on patient-oriented research. This award will enable the candidate to achieve her career objectives, which are to gain additional experience and training in patient-oriented research and become an independent funded investigator in patient-oriented clinical research. Mentors: The primary mentor will be Dr. Anna Dongari-Bagtzoglou, who has extensive expertise in oral infection and inflammation. This combination of clinical and basic science expertise will ensure the comprehensive training program. Environment: A well-established research program in the proposed research area is in place. An NIH-funded GCRC provides supportive services for clinical research. Strong evidence of institutional commitment to the candidate's career development is also documented in the application. Career Development Plan: The didactic component will include course-work in areas relevant to patient-oriented research and nephrology. The clinical component will include experience in patient-oriented research projects. The laboratory component will include hands-on experience in inflammation laboratory techniques. Research Plan: We hypothesize that periodontal infections are highly prevalent in the CKD population and may affect the systemic inflammatory status of CKD patients. Moreover, we hypothesize that following periodontal treatment, the systemic inflammatory status of CKD patients will improve confirming the direct contribution of chronic periodontitis to the systemic inflammatory of CKD subjects. Specific Aim 1: a) to compare the prevalence of periodontal infection between CKD patients and non-CKD population and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients. Specific Aim 2: a) to assess the levels of the systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD populations, and b): to compare the serum EL-6 and CRP levels at baseline and 2 months after periodontal treatment. PUBLIC HEALTH RELEVANCE: The study will compare the prevalence of gum disease between renal and non-renal populations. Given the fact that the higher the levels of inflammatory markers in the circulation, the higher the risk for heart disease, the study will assess the effect of gum infection on the overall inflammatory status of renal subjects. Also, the study will assess the effect of gum treatment on the systemic inflammatory status of renal patients.

描述（由申请人提供）：候选人：候选人致力于从事学术牙科职业，重点是以患者为导向的研究。该奖项将使候选人能够实现她的职业目标，这将获得以患者为导向的研究的额外经验和培训，并成为以患者为导向的临床研究的独立资助的研究者。导师：主要导师将是Anna Dongari-Bagtzoglou博士，他在口腔感染和炎症方面拥有广泛的专业知识。临床和基础科学专业知识的这种结合将确保全面的培训计划。环境：拟议的研究领域的一项公认的研究计划已经到位。 NIH资助的GCRC为临床研究提供支持服务。该应用程序还记录了对候选人职业发展的机构承诺的有力证据。职业发展计划：教学成分将包括与以患者为导向的研究和肾脏相关领域的课程工作。临床成分将包括以患者为导向的研究项目的经验。实验室组件将包括炎症实验室技术方面的动手经验。研究计划：我们假设牙周感染在CKD人群中非常普遍，可能会影响CKD患者的全身性炎症状态。此外，我们假设在牙周治疗后，CKD患者的全身性炎症状态将改善确认慢性牙周炎对CKD受试者的全身性炎症的直接贡献。具体目的1：a）比较CKD患者与非CKD人群之间牙周感染的患病率和b）探索牙周感染的存在与CKD患者的尿症状态之间的关联。具体目标2：a）评估在CKD种群存在或不存在牙周感染的情况下IL-6和CRP的系统性炎症标记水平，b）：比较基线和基线和CRP水平牙周治疗后2个月。 公共卫生相关性：该研究将比较肾脏和非肾脏人群之间牙龈疾病的患病率。鉴于循环中炎症标记的水平越高，心脏病的风险越高，该研究将评估牙龈感染对肾脏受试者总体炎症状态的影响。此外，该研究将评估牙龈治疗对肾脏患者全身炎症状态的影响。