Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

外观和性能增强药物使用的生物行为后果

• 批准号: 7530230
• 负责人: THOMAS B HILDEBRANDT
• 金额: $ 17.67万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7530230
• 关键词: Adult; Age; Aggressive behavior; Alcohol or Other Drugs use; Aminobutyric Acid; Aminobutyric Acids; Anabolic steroids; Appearance; Area; Argipressin; Athletic; Behavior; Behavioral; Biological; Characteristics; Class; Clinical; Clinical Research; Data; Dependence; Development; Disease; Drug usage; Drug user; Eating; Education; Educational Background; Endocrine; Environment; Ethical Issues; Exercise; Fatty acid glycerol esters; Functional disorder; Funding; Goals; Growth; Hormonal; Hormones; Impulsivity; Individual; K-Series Research Career Programs; Knowledge; Learning; Legal; Licensing; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Medical; Metabolic; Methodology; Mission; Modeling; Moods; Muscle; Nandrolone; Neuroendocrinology; Neurosecretory Systems; Neurotransmitters; Pattern; Performance; Personality; Pharmaceutical Preparations; Policies; Prevention intervention; Psychiatry; Psychologist; Public Health; Purpose; Range; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Scientist; Serotonin; Statistical Models; Substance abuse problem; System; Testosterone; Thinking; Time; Training; Translational Research; Week; Weight; Work; base; behavior change; career; clinically significant; data modeling; design; disturbance in affect; experience; falls; improved; interest; male; medical schools; patient oriented; professor; programs; response; self esteem; skills; social; theories

DESCRIPTION (provided by applicant): The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Psychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and aggression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.

描述（由申请人提供）：拟议的 K23 以患者为导向的职业发展奖旨在为 PI 提供必要的培训，以研究外观和性能增强药物 (APED) 使用的生物行为后果的个体差异。候选人：PI 是助理教授和执业临床心理学家，目前在西奈山医学院 (MSSM) 的饮食和体重失调项目工作。他计划利用 K23 成为 R01 资助的研究人员，与基础科学家和转化科学家密切合作，应对 APED 使用带来的临床、伦理和科学挑战。为了实现这些职业目标，他将使用 K23 获得研究 APED 用户的内分泌/神经内分泌功能与攻击/冲动之间关系所需的知识、技能和能力。他的具体培训目标是 (a) 学习理论、方法和临床方法来研究 APED 使用的病理性和非病理性形式之间的区别，(b) 通过转化研究发展可用的理论和方法的工作知识研究激素与行为的关系，(c) 获得将激素失调与精神疾病联系起来的理论和方法方面的专业知识，(d) 更好地了解与研究药物滥用相关的医学、法律和伦理问题，以及 (e) 获得专业知识纵向生物数据的数据建模和统计分析。环境：Pi 提出的培训计划和职业目标与 MSSM 精神病学系的使命宣言一致，即整合转化和临床研究，特别是在神经内分泌学领域。希尔德布兰特博士拥有丰富的专业知识和资源，包括研究内分泌和神经内分泌功能所需的实验室设施。研究：尽管已经观察到一系列精神障碍，但使用 APED 最可靠的精神后果是冲动攻击性增加。该监督研究项目将是一项纵向研究，比较 60 名成年男性 APED 使用者在不同时间（周期内和周期外）的激素和精神失调（攻击性和冲动）程度，并与 20 名年龄、锻炼和教育程度相匹配的人进行比较。控制。分段潜在生长曲线模型将用于研究周期内和周期外的变化，并将探索以下变化的预测因素：APED 特征（数量、持续时间和模式）、年龄、精神病史、性格和病史APED 使用）。相关性：拟议研究的结果将有助于确定导致 APED 使用精神后果的内分泌功能障碍以及预测这些精神后果的使用者特征。这项研究的意义在于为与这一日益严重的公共卫生问题相关的预防、干预和政策决策提供信息。