General Brain Arousal and Risk for Eating Disorder

一般大脑唤醒和饮食失调的风险

基本信息

批准号：
10365378
负责人：
THOMAS B HILDEBRANDT
金额：
$ 43.41万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10365378
关键词：
10 year old 12 year old 13 year old Accounting Adolescence Adolescent Age Anterior Arousal Back Behavior Behavioral Binge Eating Brain Clinical Cognitive Computer Models Corpus striatum structure Cues Data Development Diagnosis Eating Behavior Eating Disorders Emotional Endocrine Ensure Environment Female Food Functional Magnetic Resonance Imaging Genetic Risk Gonadal Hormones Graph Hormonal Hormones Inferior Insula of Reil Link Locomotion Mediating Mediation Modality Modeling Motor Activity Neuraxis Neurobiology Neurosecretory Systems Ovarian hormone Positioning Attribute Property Psychological Techniques Puberty Research Rewards Risk Role Seminal Sex Differences Signal Transduction Social Environment Substance of Abuse Testing Twin Studies Validation Work boys cognitive development cohort cost critical developmental period disorder risk early adolescence emotional experience feeding financial incentive follow-up functional status girls heuristics longitudinal dataset motivated behavior prepuberty psychosocial response reward processing sensory input sex sexual dimorphism social theories

项目摘要

The prepubertal gonadal hormone surge that primes the rapid social and emotional development of adolescence has specific influences on female brains that may account for the accelerated risk for disordered eating and development of binge eating in girls relative to boys. We propose to test a model of sex differences in the risk for binge eating in early adolescence that emphasizes the differential influence of gonadal hormone status on the development of functional brain networks in girls relative to boys to account for the enhanced risk during this vulnerable period. The model leverages general brain arousal theory to predict the effect of gonadal hormones on functional brain networks, and builds on theoretical work by the MPI, seminal work by Dr. Kelly Klump and colleagues on moderated genetic risks for disordered eating in twin studies, and the pioneering work of Dr. Donald Pfaff and colleagues on the activating effects of gonadal hormones. The specific aims of this R01 project are two-fold: 1) to test for sex differences in the mediation of binge eating risk by gonadal hormonal influences on brain networks for arousal, reward processing, emotional salience, and inhibitory control at baseline and longitudinally over 2-year follow-up; and 2) to develop a computational model of general brain arousal to explain sex differences in the risk for binge eating in early adolescence. The central hypotheses are that (i) gonadal hormone status will predict the developmental status of functional brain networks for arousal, reward processing, emotional salience, and inhibitory control longitudinally in girls but not boys; (ii) these neuroendocrine interactions will mediate the risk for binge eating longitudinally in girls but not boys; and (iii) gonadal hormone status will predict covariation between these brain networks in girls but not boys, suggesting a sexually dimorphic mechanism for gonadal hormones to influence a range of behaviors characterized by altered responses to salient, rewarding, and stressful environmental cues. The large set of clinical, endocrine, and functional magnetic resonance imaging (fMRI) data collected for the Adolescent Brain Cognitive Development (ABCD) study at baseline and follow-up presents an ideal mechanism to test this model of sex differences in risk for binge eating during the critical developmental period in early puberty when gonadal hormone levels surge and maladaptive eating behaviors first emerge. These aims have direct

青春期前性腺激素激增，促进社交和情感的快速发展青春期对女性大脑有特定的影响，这可能是导致紊乱风险加速的原因相对于男孩，女孩的饮食和暴饮暴食的发展。我们建议测试性别差异模型青春期早期暴饮暴食的风险强调性腺激素的不同影响女孩相对于男孩的功能性大脑网络的发育状况，以解释风险增加的原因在这个脆弱的时期。该模型利用一般大脑唤醒理论来预测性腺的影响激素对功能性大脑网络的影响，并以 MPI 的理论工作和 Kelly 博士的开创性工作为基础克伦普及其同事在双胞胎研究中研究了饮食失调的适度遗传风险，以及开创性的研究 Donald Pfaff 博士及其同事关于性腺激素激活作用的研究工作。该 R01 项目的具体目标有两个：1）测试中介作用中的性别差异性腺激素对大脑网络的唤醒、奖励处理、情绪影响导致暴食风险基线和 2 年随访期间的显着性和抑制控制； 2）开发一个一般大脑唤醒的计算模型来解释早期暴饮暴食风险的性别差异青春期。中心假设是（i）性腺激素状态将预测发育唤醒、奖励处理、情绪显着和抑制控制的功能性大脑网络的状态纵向发生在女孩身上，但男孩没有； (ii) 这些神经内分泌相互作用会介导暴食的风险纵向发生在女孩身上，但男孩没有； (iii) 性腺激素状态将预测这些大脑之间的协变女孩而不是男孩的网络，表明性腺激素影响的性别二态性机制一系列行为，其特征是对显着的、有益的和有压力的环境的反应改变提示。收集的大量临床、内分泌和功能磁共振成像 (fMRI) 数据青少年大脑认知发展（ABCD）基线和后续研究提供了一个理想的结果测试关键发育期暴食风险性别差异模型的机制在青春期早期，性腺激素水平激增，适应不良的饮食行为首先出现。这些目标有直接