Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders

低体重饮食失调青少年的奖励系统和食物避免

基本信息

批准号：
10222953
负责人：
THOMAS B HILDEBRANDT
金额：
$ 22.09万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-19 至 2021-08-31
项目状态：
已结题

项目摘要

Project Summary Low weight eating disorders are severe psychiatric disorders that most often develop in adolescence, have a chronic course, and evidence poor response to treatment. This project examined the hypothesis that the insula-amygdala-ventral striatum (IAVS) neurocircuit is responsible for abhorrent food-cue learning in adolescents with LW-EDs and that this learning underlies the core construct of food avoidance. We tested this hypothesis by experimentally manipulating the functionally connectivity of this neurocircuit by utilization of novel clinical treatment, family based interoceptive exposure (FBT-IE) vs. standard family therapy. To delineate this aversive neurocircuit, we utilized novel computational approach integrating facial electromyography into the fMRI of food-cue reversal learning task. This fMRI-EMG was designed to empirically establish aversive responses to food-cues among patients and pleasurable responses to food avoidance. We sought to distinguish pathological responses of the IAVS neurocircuit and its relationship to affective response from healthy controls, establishing the neurocircuit as a key source for divergences in eating, clinical symptoms, and behavior between groups. In addition, we sought to test weather FBT-IE leads to differential changes in clinical, laboratory eating, neurocircuit, and behavioral responses to food cues. At this point, we have completed data collection on 60 patients with LW-EDs and 22 health controls. We have begun analyzing the clinical data. However, 2 of our controls were lost to COVID disruption and 7 of the remaining 20 have incomplete or compromised data. Due to the suspension of activities, we will run out of funding before the end of the NCE because of our efforts to pay staff through the COVID related suspensions. Consequently, this proposed supplement seeks funds to support to staff to complete data collection for the healthy control subjects (8 new subjects, 2 replaced from COVID loss, and 7 replacement of compromised existing data, totaling 17 new healthy control subjects.)

项目概要低体重饮食失调是一种严重的精神疾病，最常见于青春期，具有慢性病程，并且证据表明对治疗反应不佳。该项目检验了以下假设：岛叶-杏仁核-腹侧纹状体（IAVS）神经回路负责令人厌恶的食物提示学习患有 LW-ED 的青少年，这种学习是避免食物的核心结构的基础。我们测试了这个通过利用实验操纵该神经回路的功能连接来提出假设新颖的临床治疗，基于家庭的内感受暴露（FBT-IE）与标准家庭治疗。到为了描绘这种厌恶的神经回路，我们利用新颖的计算方法整合面部将肌电图纳入食物提示逆转学习任务的功能磁共振成像中。该 fMRI-EMG 旨在根据经验建立患者对食物线索的厌恶反应和对食物的愉悦反应回避。我们试图区分 IAVS 神经回路的病理反应及其与来自健康对照的情感反应，将神经回路确立为差异的关键来源饮食、临床症状和群体之间的行为。此外，我们还试图测试天气 FBT-IE 引线临床、实验室饮食、神经回路和对食物线索的行为反应的差异变化。在此截至目前，我们已经完成了 60 名 LW-ED 患者和 22 名健康对照者的数据收集。我们已经开始了分析临床数据。然而，我们的 2 个控制系统因新冠肺炎疫情中断而丢失，其余 20 个控制系统中的 7 个控制系统丢失数据不完整或受损。由于活动暂停，我们的资金将在之前耗尽 NCE 的结束是因为我们努力通过与新冠病毒相关的停职来向员工支付工资。最后，该拟议补充寻求资金支持工作人员完成健康控制的数据收集受试者（8 个新受试者，2 个因新冠病毒丢失而被替换，7 个替换受损的现有数据，总共 17 名新的健康对照受试者。）