2012 Ligand Recognition and Molecular Gating Gordon Research Conference

2012年配体识别与分子门控戈登研究会议

基本信息

批准号：
8252998
负责人：
Nancy Ryan Gray
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8252998
关键词：
ATP-Binding Cassette Transporters Address Adrenergic Receptor Animal Model Area Behavior Binding Biochemistry Cardiovascular Diseases Cellular biology Collaborations Communities Critiques Cystic Fibrosis Data Development Disease Dopamine Receptor Employee Strikes Ensure Epilepsy Eukaryota Evaluation Financial Support Future G Protein-Coupled Receptor Genes G-Protein-Coupled Receptors Generations Glutamate Receptor Goals Health Human Hypertension Individual Integral Membrane Protein Ion Channel Ions Knowledge Lead Ligand Binding Ligands Link Lipids Malabsorption Syndromes Malignant Neoplasms Membrane Membrane Proteins Membrane Structure and Function Mental Depression Mission Molecular Molecular Conformation Nervous system structure Neurodegenerative Disorders Neurotransmitters Pharmacologic Substance Physiological Physiology Postdoctoral Fellow Potassium Channel Potassium Glutamate Process Protein Binding Proteins Recruitment Activity Regulation Research Research Personnel Resolution Role Science Scientist Seasons Senior Scientist Sensory Signal Transduction Signaling Protein Structure Study Section System Technology Therapeutic Agents Training Update Vision Work Writing base cohort deafness design experience graduate student improved insight meetings molecular recognition multidisciplinary nervous system disorder novel strategies novel therapeutics programs receptor research study skin disorder small molecule structural biology success symposium

项目摘要

DESCRIPTION: The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held on Jan 15 - 20, 2012, in Ventura, CA. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins) and transmit signals across membranes. The main objective of the conference is to share the newest knowledge on ion channels, G protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional information to understand mechanisms. A unifying theme in these three different classes of membrane proteins is that ligand binding, gating, and/or transport involves conformational changes. The characterization of defined, mechanistically relevant conformations of fully functional protein will be a focus of the 2012 conference. The program will have about 40 speakers, well-established leaders in the field of membrane protein research as well as promising young investigators. Nine sessions will broadly address structure and mechanism of ion channels involved in sensory transduction, potassium channels and glutamate receptor channels, secondary transporters, ATP-driven transporters, 2-adrenergic receptors, dopamine receptors and other GPCRs. There will also be sessions on new approaches for membrane protein structural biology and on lipid-protein interactions. The goal of the Gordon Research Conference on Ligand Recognition and Molecular Gating is to stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference. Understanding the structure and function of these membrane bound molecules is one of the most important goals of the 21st century, both for science and for development of new therapeutics. Results discussed and new experiments designed have impact on areas such as cancer (ABC transporters), vision/depression/cardiovascular diseases (G-protein coupled receptors), neurodegenerative diseases, skin diseases, deafness, developmental abnormalities and neurological diseases such as epilepsy (ion channels). Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.

描述：关于配体识别和分子门控的戈登研究会议将于 2012 年 1 月 15 日至 20 日在加利福尼亚州文图拉举行。会议的广泛和长期目标是增加我们对整合膜蛋白如何结合或识别配体（离子、小分子、蛋白质）并跨膜传输信号的理解。会议的主要目标是分享有关离子通道、G蛋白偶联受体和所有类型转运蛋白的最新知识，重点是将高分辨率结构数据与功能信息相结合以了解机制。这三种不同类别的膜蛋白的一个统一主题是配体结合、门控和/或运输涉及构象变化。全功能蛋白质的明确的、机械相关的构象的表征将是 2012 年会议的焦点。该计划将有大约 40 名演讲者，其中包括膜蛋白研究领域的知名领导者以及有前途的年轻研究人员。九场会议将广泛讨论涉及感觉转导的离子通道、钾通道和谷氨酸受体通道、二级转运蛋白、ATP驱动的转运蛋白、2-肾上腺素受体、多巴胺受体和其他GPCR的结构和机制。还将举办有关膜蛋白结构生物学和脂质-蛋白质相互作用新方法的会议。戈登配体识别和分子门控研究会议的目标是通过聚集该领域的一些最重要的科学家来展示和比较结果、讨论新想法并建立合作，从而促进膜蛋白研究领域的进步。公共健康相关性：该应用的健康相关性在于，目前超过 50% 的药物靶标都是本次会议讨论的类型的整合膜蛋白。了解这些膜结合分子的结构和功能是 21 世纪最重要的目标之一，无论是对于科学还是对于新疗法的开发。讨论的结果和设计的新实验对癌症（ABC 转运蛋白）、视力/抑郁/心血管疾病（G 蛋白偶联受体）、神经退行性疾病、皮肤病、耳聋、发育异常和癫痫等神经系统疾病（离子渠道）。免责声明：请注意，以下评论是由审稿人在研究部分会议之前准备的，并且以基本上未经编辑的形式提供。虽然审稿人有机会根据小组的讨论更新或修改他们的书面评估，但不能保证个人批评在会议讨论后得到更新。因此，评论可能无法完全反映小组讨论结束时个别审稿人的最终意见或小组的最终多数意见。因此，讨论的简历和摘要是审稿人在会议上实际认为关键的内容的最终决定。