2013 Malaria Gordon Research Conference and Gordon Research Seminar

2013年疟疾戈登研究会议暨戈登研究研讨会

• 批准号: 8528865
• 负责人: Nancy Ryan Gray
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-22 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528865
• 关键词: Address; African; Antimalarials; Applied Research; Basic Science; Biochemistry; Biology; Cells; Cellular biology; Chemicals; Child; Clinical; Collaborations; Communities; Data; Development; Discipline; Disease; Drug resistance; Ensure; Environment; Evolution; Feedback; Fertilization; Fostering; Future; Genome; Goals; Government; Human; Human Genetics; Immunity; Immunology; Incidence; Infant; Infection; Insecticides; International; Intervention; Lead; Learning; Licensing; Link; Liver; Malaria; Malaria Vaccines; Molecular; Molecular Genetics; Molecular and Cellular Biology; Parasite resistance; Parasites; Pathogenesis; Pharmaceutical Chemistry; Pharmaceutical Preparations; Phase III Clinical Trials; Plasmodium; Plasmodium vivax; Postdoctoral Fellow; Public Health; Reporting; Research; Research Personnel; Research Priority; Research Project Grants; Residual state; Resistance; Running; Science; Scientist; Series; Southeastern Asia; Staging; Students; Systems Biology; Techniques; Technology; Thinking; Time; Touch sensation; Vaccine Research; Vaccines; Virulence; Vision; Work; combat; design; drug development; falls; functional genomics; fundamental research; global health; graduate student; human disease; meetings; new technology; novel; novel vaccines; programs; public health relevance; resistance mechanism; symposium; tool; transmission process; vaccine development; vector; vector mosquito

DESCRIPTION (provided by applicant): The 2013 Malaria Gordon Research Conference (GRC) and its first associated Gordon Research Seminar (GRS) will focus on "Molecular and Cellular Biology of Malaria". These meetings will bring together leading international scientists from diverse disciplines including biochemistry, medicinal chemistry, vaccine research, molecular genetics, structural, cell biology and systems biology to focus on the most recent advances in malaria. The meeting will emphasize molecular and cellular aspects of the malaria parasite's basic biology, immunology, host-parasite-vector interactions and pathogenic mechanisms. The format will provide a stimulating forum to discuss cutting edge fundamental and applied research on malaria, with an emphasis on programs that contribute to the development of vaccines and drugs. The first GRC on Malaria was held in September 1997, and has become a well-established series of conferences that run every two years, and alternate between a meeting focused on basic oriented research and a meeting focused on more field and clinical aspects. The 2013 meeting will focus on the former: that is will emphasize basic research into host-parasite-vector interactions as well as the concepts around the development of novel interventions. The Malaria GRC has been extremely popular in previous years with one of the highest attendances among the Gordon Conferences and is usually oversubscribed. We also anticipate that the introduction of the first Malaria Gordon Research Seminar will promote active participation of young malaria researchers into the global collaborative efforts to combat this disease. The timing of this Malaria GRC in 2013 will coincide with the availability of advanced data from the first phase 3 clinical trials of a malaria vaccine involving ~10,000 African infants and children. Presentation of these results will be a major focus of the meeting. Against this, reports are beginning to emerge of parasites resistant to the newest anti-malarials spreading in Southeast Asia and the timing of the Malaria GRC will also be well suited to disseminate and discuss the very latest findings on this crucial topic. There is an urgent need to understand the emerging mechanism(s) of this resistance and of the ongoing requirements for new interventions and a deeper understanding of host-parasite-vector interactions. The 2013 Malaria GRC and its first associated GRS are important opportunities for established and emerging malaria research leaders to gather and address these issues under the auspices of a conference series that has a reputation for presentation of the latest unpublished data followed by vigorous and extensive discussion.

描述（由申请人提供）：2013 年疟疾戈登研究会议 (GRC) 及其首届相关戈登研究研讨会 (GRS) 将重点讨论“疟疾的分子和细胞生物学”。这些会议将汇集来自生物化学、药物化学、疫苗研究、分子遗传学、结构、细胞生物学和系统生物学等不同学科的领先国际科学家，重点关注疟疾方面的最新进展。会议将强调疟疾寄生虫的基本生物学、免疫学、宿主-寄生虫-载体相互作用和致病机制的分子和细胞方面。该形式将提供一个激动人心的论坛，讨论疟疾的前沿基础和应用研究，重点是有助于疫苗和药物开发的项目。第一届疟疾 GRC 于 1997 年 9 月举行，现已成为每两年举办一次的成熟系列会议，交替举办侧重于基础研究的会议和侧重于更多领域和临床方面的会议。 2013 年会议将重点关注前者：即强调宿主-寄生虫-媒介相互作用的基础研究以及围绕新型干预措施开发的概念。疟疾 GRC 在前几年非常受欢迎，是戈登会议中出席人数最高的会议之一，并且通常会超额认购。我们还预计，首届疟疾戈登研究研讨会的推出将促进年轻疟疾研究人员积极参与抗击这种疾病的全球合作努力。 2013 年疟疾 GRC 的召开时间恰逢疟疾疫苗第一期 3 期临床试验的先进数据发布，该疫苗涉及约 10,000 名非洲婴儿和儿童。这些成果的展示将是本次会议的一大焦点。与此相反，有报道称寄生虫对最新的抗疟疾药物具有抗药性，并在东南亚蔓延，疟疾 GRC 的时机也非常适合传播和讨论这一关键主题的最新发现。迫切需要了解这种耐药性的新机制，以及对新干预措施的持续需求，并更深入地了解宿主-寄生虫-媒介相互作用。 2013 年疟疾 GRC 及其第一个相关的 GRS 为成熟和新兴的疟疾研究领导者提供了重要机会，他们可以在系列会议的主持下收集和解决这些问题，该系列会议以介绍最新未发表的数据并随后进行激烈和广泛的讨论而闻名。