2011 Cell-Cell Fusion Gordon Research Conference and Seminar

2011细胞-细胞融合戈登研究会议暨研讨会

基本信息

批准号：
8127175
负责人：
Nancy Ryan Gray
金额：
$ 1.3万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-06 至 2011-10-13
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8127175
关键词：
Address Affect Aging Animal Model Award Biological Cell fusion Cell membrane Cells Communities Crystalline Lens Cytokinesis Defect Development Discipline Disease Educational workshop Endocytosis Event Exocytosis Feedback Funding Funding Agency Future Future Generations Health Hereditary Disease In Vitro Individual Infertility International Knowledge Life Location Malignant Neoplasms Membrane Membrane Fusion Methodology Methods Molecular Mus Muscle Myoblasts Myopathy Names Nature Neurodegenerative Disorders New England Organ Osteogenesis Participant Phase Placenta Postdoctoral Fellow Process Rare Diseases Recording of previous events Request for Applications Research Research Personnel Research Project Grants Science Scientist Sexual Development Sister Stem Cell Research Stem cells Syndrome Time Training Translating Travel Universities Viral Virus Diseases Work abstracting base bone cancer stem cell design developmental genetics egg fascinate fly fundamental research fungus graduate student high throughput screening human disease in vivo malformation meetings member multidisciplinary novel novel therapeutics pathogen planetary Atmosphere posters programs sex single molecule sperm cell stem cell biology symposium trafficking

项目摘要

DESCRIPTION (Provided by Applicant): The Gordon Research Conference (GRC) on Cell-Cell Fusion will provide scientists from a wide range of disciplines with the newest research findings on the functions of cell fusion in development in a number of model organisms and in a variety of diseases. The emphasis will be on emerging universal mechanisms and future applications to cancer and stem cell research. This research conference will be the third Cell-Cell Fusion GRC and it is part of over 150 conferences that will be organized in 2011 by the GRC, an organization internationally known for the cutting edge nature of its meetings. Attendance at the meeting has grown steadily since its inception five years ago, and in 2011 the organizers expect to have 140 participants. The 2011 GRC on Cell-Cell Fusion will be held August 7-12, 2011 at the University of New England in Biddeford, ME. The program for the meeting described in this application has been designed around the theme of "Cell Fusion in Sex, Life, Development, and Disease". The organizer will deal mostly on the fundamental process of cell fusion during health and disease as well as the relationship between cell fusion and the larger fields of membrane fusion and fission during exocytosis, endocytosis, viral entry, and cytokinesis. The cell fusion community is entering a particularly fascinating phase as the fundamental principles of fusion emerging from theoretical analyses and studies on viral entry and intracellular trafficking start to be applied to understanding the functions and mechanisms of cell-cell fusion in development as well as disease. Important processes such as membrane fusion and fission, egg-sperm fusion, formation of bones, muscles, eye lens, stem cells, placenta, rare genetic diseases, and the invasion of cells by pathogens will be covered in eight sessions. This progress is being helped by classic and new methodology, including high throughput screening, developmental genetics in model organisms (e.g., fungi, flies, worms, and mice), and single-molecule biophysical methods. Exciting developments will be covered by the invited speakers, along with the latest progress on the basic mechanisms and applications of cell membrane fusion in vitro and in vivo. In addition there will be one round table discussion on myoblast fusion, a hotly debated topic that will encourage wide participation and scholarly organized discussions. The first Gordon-Kenan Research Seminar (GRS) on Cell-Cell fusion will be held August 6-7, 2011. This new GRS is organized by graduate students and postdoctoral fellows, and the activities during the GRS will be oriented to junior investigators and are intended to: (1) provide them with the basic background on mechanisms involved in membrane fusion in health and disease necessary to maximize their understanding of the science which will be discussed in the subsequent conference, (2) receive feedback on their ongoing research projects from experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote networking between junior and more senior researchers in the field. It is fully anticipate that the scientific discussions, research talks, poster sessions, and other informal interactions among the participants of this conference will contribute to advancing our understanding of novel molecular mechanisms involved in cell fusion during normal development as well as in human diseases, and will set the basis for the development of multidisciplinary projects aimed at discovering new treatments for these disorders. NARRATIVE: The Cell-Cell Fusion Gordon Research Conference (GRC) together with the first sister Gordon-Kenan Research Seminar (GRS) will bring leaders in diverse scientific disciplines together with graduate students and postdoctoral fellows constituting the future generation of researchers in the emerging field of cell fusion. The scientific presentations, discussions, round table discussions, as well as workshops during the GRC and GRS conferences on cell-cell fusion are tailored to expand our knowledge on the mechanisms by which membranes fuse in model organisms, and may contribute to our understanding of the first events in sexual development, the formation of many organs, cancer, stem cell biology, and rare diseases. The exciting, friendly, and multidisciplinary atmosphere that has traditionally characterized the Cell-Cell Fusion GRC will provide the ideal setting for the intellectual development and implementation of groundbreaking approaches to treat some cancers, as well as use stem cells to address fundamental biological questions and diseases.

描述（由申请人提供）：关于细胞-细胞融合的戈登研究会议 (GRC) 将为来自各个学科的科学家提供关于细胞融合在许多模型生物体和多种生物体发育过程中的功能的最新研究成果。各种疾病。重点将放在新兴的通用机制以及未来在癌症和干细胞研究中的应用。此次研究会议将是第三届细胞-细胞融合 GRC，它是 GRC 将于 2011 年组织的 150 多个会议的一部分，GRC 是一个以其会议的前沿性而闻名的国际组织。自五年前举办以来，参加会议的人数稳步增长，组织者预计 2011 年将有 140 名与会者。 2011 年细胞-细胞融合 GRC 将于 2011 年 8 月 7 日至 12 日在缅因州比迪福德的新英格兰大学举行。本申请中描述的会议议程是围绕“性、生命、发育和疾病中的细胞融合”主题设计的。组织者将主要讨论健康和疾病期间细胞融合的基本过程，以及细胞融合与胞吐作用、内吞作用、病毒进入和胞质分裂过程中更大的膜融合和裂变领域之间的关系。细胞融合界正在进入一个特别令人着迷的阶段，因为病毒进入和细胞内运输的理论分析和研究中出现的融合基本原理开始应用于理解细胞与细胞融合在发育和疾病中的功能和机制。八个分会场将涵盖膜融合与裂变、卵子与精子融合、骨骼、肌肉、晶状体、干细胞、胎盘、罕见遗传病、病原体侵入细胞等重要过程。这一进展得益于经典和新方法，包括高通量筛选、模式生物（例如真菌、苍蝇、蠕虫和小鼠）的发育遗传学以及单分子生物物理方法。受邀演讲者将介绍令人兴奋的进展，以及体外和体内细胞膜融合的基本机制和应用的最新进展。此外，还将举行一场关于成肌细胞融合的圆桌讨论，这是一个备受争议的话题，将鼓励广泛参与和学术组织的讨论。第一届关于细胞-细胞融合的戈登-凯南研究研讨会 (GRS) 将于 2011 年 8 月 6 日至 7 日举行。这个新的 GRS 由研究生和博士后研究员组织，GRS 期间的活动将面向初级研究人员和旨在：(1) 为他们提供健康和疾病中膜融合机制的基本背景，以最大限度地加深他们对科学的理解，这将在随后的会议中讨论，(2) 接收有关他们正在进行的研究项目的反馈来自专家(3) 促进他们与该科学界高级成员的互动，以促进该领域初级和高级研究人员之间的联系。完全可以预见，本次会议参与者之间的科学讨论、研究讲座、海报会议和其他非正式互动将有助于增进我们对正常发育期间以及人类疾病中细胞融合所涉及的新分子机制的理解，并且将为开发旨在发现这些疾病的新疗法的多学科项目奠定基础。叙述：细胞-细胞融合戈登研究会议 (GRC) 以及第一届姐妹戈登-凯南研究研讨会 (GRS) 将汇集不同科学学科的领导者以及构成新兴领域未来一代研究人员的研究生和博士后研究员的细胞融合。 GRC 和 GRS 会议期间关于细胞-细胞融合的科学演讲、讨论、圆桌讨论以及研讨会旨在扩展我们对模型生物体膜融合机制的了解，并可能有助于我们对细胞融合机制的理解。性发育的最初事件、许多器官的形成、癌症、干细胞生物学和罕见疾病。细胞-细胞融合 GRC 传统上令人兴奋、友好和多学科的氛围将为智力开发和实施治疗某些癌症的突破性方法以及使用干细胞解决基本的生物学问题和疾病提供理想的环境。