Nonhuman Primate

非人类灵长类动物

基本信息

批准号：
8117934
负责人：
Michael K Axthelm
金额：
$ 84.72万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-15 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8117934
关键词：
AIDS Vaccines Adult Animal Housing Animals Autopsy Bioinformatics Body Composition Budgets California Cercopithecidae Clinical Clinical Management Communicable Diseases Complex Cytomegalovirus Data Data Collection Development Ensure Evaluation Fostering Genetic Goals HIV vaccine Human Human Resources Immune system Immunology Immunosuppression Indium Institutes Instruction Investigation Leadership Life Macaca mulatta Metabolism Modeling Monitor Oregon Pathogenesis Pathogenicity Pathologic Performance Physiological Primates Procedures Process Protocols documentation Quality Control Reproduction Research Research Design Research Infrastructure Research Personnel Resources SIV Safety Sampling Specimen Handling Structure Supervision T memory cell T-Lymphocyte Technical Expertise Tropism Vaccine Design Vaccine Research Vaccine Therapy Vaccines Viral animal care animal facility attenuation comparative efficacy testing experience fetal gene therapy immunogenicity meetings nonhuman primate novel primate development programs sample collection transmission process vaccine development vector vector-based vaccine virology

项目摘要

The Nonhuman Primate (NHP) Core seeks to consolidate supervision and performance ofthe NHP experimental protocols assessing the immunogenicity, shedding and efficacy of RhCMV/SIV vectors proposed as part ofthe HIV Vaccine Research and Design (HIVRAD) Program proposal "Development of Effector-Memory T Cell AIDS Vaccine" into a structured Core composed of highly experienced research personnel. This Core will provide the expertise and technical support required to insure successful completion of the multifaceted and extensive NHP research protocols supporting Project 1 - "Development and analysis of replication-deficient CMV vectors". Project 2 - "Attenuation of CMV vector pathogenicity and transmission by alterating viral tropism" and Project 3 - "Enhancing RhCMV/SIV vector efficacy". The global objective ofthe Core is to provide leadership and technical expertise to ensure consistency and quality control in animal selection, execution of study protocols, application of experimental procedures, animal observations and data collection necessary to meet the objectives of the HIVRAD Program's vector development and efficacy assessment protocols. To accomplish this, the Core will manage and directly supervise all NHP studies forthe HIVRAD including: 1) animal selection; 2) animal housing and general husbandry; 3) experimental procedures and clinical management; 4) specimen collection and processing; 5) necropsy studies; and 6) acquisition and management of animal demographic, physiologic, clinical, and pathologic data. RELEVANCE (See instructions): NHP research is expensive, and requires highly specialized resources and personnel. Consolidation of multiple interactive projects into a integrative multdicipline core had decided advantages in correlation of results, efficient animals handling and speciment process, use of fewer animals and efficient use of animals facility space and resources.

非人类灵长类动物 (NHP) 核心旨在巩固 NHP 的监督和绩效评估 RhCMV/SIV 载体的免疫原性、脱落和功效的实验方案作为艾滋病毒疫苗研究和设计 (HIVRAD) 计划提案“开发 “效应记忆T细胞艾滋病疫苗”成为由经验丰富的研究组成的结构化核心人员。该核心将提供确保成功所需的专业知识和技术支持完成支持项目 1 -“开发”的多方面和广泛的 NHP 研究协议复制缺陷型 CMV 载体的分析和分析”。项目 2 -“CMV 载体致病性的衰减和通过改变病毒向性传播”和项目 3 - “增强 RhCMV/SIV 载体功效”。全球核心的目标是提供领导力和技术专业知识，以确保一致性和质量动物选择的控制、研究方案的执行、实验程序的应用、动物实现 HIVRAD 计划载体目标所需的观察和数据收集开发和功效评估协议。为了实现这一目标，核心将管理并直接监督 HIVRAD 的所有 NHP 研究，包括： 1) 动物选择； 2) 动物圈舍及一般畜牧业； 3）实验程序和临床管理； 4）标本采集和处理； 5）尸检研究； 6) 动物人口统计、生理学、临床和病理数据。相关性（参见说明）： NHP 研究成本高昂，并且需要高度专业化的资源和人员。巩固将多个互动项目纳入一个综合性多学科核心，在以下方面具有决定性的优势：结果、高效的动物处理和标本处理、使用更少的动物和有效地利用动物设施空间和资源。